Cttn - cortactin Gene

Also Known as Cttnb

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 60465

Summary

Enables Arp2/3 complex binding activity and proline-rich region binding activity. Involved in several processes, including focal adhesion assembly; modification of postsynaptic actin cytoskeleton; and plasma membrane bounded cell projection organization. Located in cell junction and clathrin-coated pit. Is active in glutamatergic synapse and postsynaptic actin Cytoskeleton. Colocalizes with actin filament; focal adhesion; and growth cone. Orthologous to human CTTN (cortactin). [provided by Alliance of Genome Resources, Apr 2022]

Cttn Products (3)

mRNA Protein Name
NM_001398643.1 NP_001385572.1 src substrate cortactin isoform 1
NM_001398644.1 NP_001385573.1 src substrate cortactin isoform 3
NM_021868.3 NP_068640.2 src substrate cortactin isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables Arp2/3 complex binding IPI
IPI: Inferred from physical interaction
18775315 RGD
enables proline-rich region binding IPI
IPI: Inferred from physical interaction
9813110 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
15159385 RGD
Biological Process GO Annotation Evidence References Source
involved in actin cytoskeleton organization IMP
IMP: Inferred from mutant phenotype
18768925 RGD
involved in cell motility IMP
IMP: Inferred from mutant phenotype
18768925 RGD
involved in focal adhesion assembly IMP
IMP: Inferred from mutant phenotype
18768925 RGD
involved in lamellipodium organization IMP
IMP: Inferred from mutant phenotype
18768925 RGD
involved in modification of postsynaptic actin cytoskeleton IDA
IDA: Inferred from direct assay
14684878 RGD
involved in modification of postsynaptic actin cytoskeleton IMP
IMP: Inferred from mutant phenotype
14684878 RGD
involved in modification of postsynaptic structure IDA
IDA: Inferred from direct assay
14684878 RGD
involved in modification of postsynaptic structure IMP
IMP: Inferred from mutant phenotype
14684878 RGD
involved in neuron projection morphogenesis IMP
IMP: Inferred from mutant phenotype
21210813 RGD
involved in positive regulation of actin filament polymerization IMP
IMP: Inferred from mutant phenotype
18768925 RGD
involved in positive regulation of chemotaxis IMP
IMP: Inferred from mutant phenotype
19373774 RGD
involved in receptor-mediated endocytosis IDA
IDA: Inferred from direct assay
12612086 RGD
involved in receptor-mediated endocytosis IMP
IMP: Inferred from mutant phenotype
19995918 RGD
involved in regulation of axon extension IMP
IMP: Inferred from mutant phenotype
21210813 RGD
involved in regulation of cell projection assembly IMP
IMP: Inferred from mutant phenotype
19373774 RGD
Cellular Component GO Annotation Evidence References Source
located in actin filament IMP
IMP: Inferred from mutant phenotype
18768925 RGD
located in cell junction IDA
IDA: Inferred from direct assay
21210813 RGD
located in clathrin-coated pit IDA
IDA: Inferred from direct assay
19995918 RGD
located in focal adhesion IMP
IMP: Inferred from mutant phenotype
18768925 RGD
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
14684878 RGD
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
14684878 RGD
located in growth cone IDA
IDA: Inferred from direct assay
21210813 RGD
is active in postsynapse IDA
IDA: Inferred from direct assay
15548644 RGD
is active in postsynaptic actin cytoskeleton IDA
IDA: Inferred from direct assay
15548644 RGD
part of voltage-gated potassium channel complex IDA
IDA: Inferred from direct assay
12151401 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

src substrate cortactin

Cttn Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Cttn Q66HL2 Cfl1 Rattus norvegicus P45592
Anti Bait CoIP
19704022
Intra
Cttn Q66HL2 Cfl1 Rattus norvegicus P45592
FRET
19704022
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03350 CTTN Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22133 Cttn Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28655 Cttn Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cttn NCBI NCBI:2017