Mc3r - melanocortin 3 receptor Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 29310

About Mc3r

Primary_assembly 3: 161,016,347-161,017,444 forward strand.mRatBN7.2:CM026976.1

This gene has 1 transcript (splice variant), 141 orthologues, 18 paralogues and is associated with 2 phenotypes.

Summary

Enables Melanocortin Receptor activity and peptide hormone binding activity. Involved in several processes, including adenylate cyclase-modulating G protein-coupled receptor signaling pathway; homoiothermy; and sodium ion homeostasis. Predicted to be integral component of plasma membrane. Predicted to be active in cytoplasm and plasma membrane. Human ortholog(s) of this gene implicated in obesity. Orthologous to human MC3R (melanocortin 3 receptor). [provided by Alliance of Genome Resources, Apr 2022]

Mc3r Products (1)

mRNA Protein Name
NM_001025270.4 NP_001020441.3 melanocortin receptor 3

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables melanocortin receptor activity IDA
IDA: Inferred from direct assay
17023527 RGD
enables melanocortin receptor activity IMP
IMP: Inferred from mutant phenotype
17023527 RGD
enables peptide hormone binding IDA
IDA: Inferred from direct assay
17023527 RGD
enables peptide hormone binding IMP
IMP: Inferred from mutant phenotype
17023527 RGD
Biological Process GO Annotation Evidence References Source
involved in adenylate cyclase-modulating G protein-coupled receptor signaling pathway IDA
IDA: Inferred from direct assay
15985309 RGD
involved in homoiothermy IMP
IMP: Inferred from mutant phenotype
21091037 RGD
involved in regulation of blood pressure IMP
IMP: Inferred from mutant phenotype
21091037 RGD
involved in regulation of heart rate IMP
IMP: Inferred from mutant phenotype
21091037 RGD
involved in sodium ion homeostasis IEP
IEP: Inferred from expression pattern
19570553 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Mc3r Protein Structure

7tmA_MC3R

7tmA_MC3R: cd15352 (38 - 309)

7tmA_MC3R

7tmA_MC3R: cd15352 (39 - 65)

7tmA_MC3R

7tmA_MC3R: cd15352 (72 - 98)

7tmA_MC3R

7tmA_MC3R: cd15352 (116 - 146)

7tmA_MC3R

7tmA_MC3R: cd15352 (158 - 178)

7tmA_MC3R

7tmA_MC3R: cd15352 (183 - 212)

7tmA_MC3R

7tmA_MC3R: cd15352 (234 - 264)

7tmA_MC3R

7tmA_MC3R: cd15352 (277 - 302)

  • 0
  • 100
  • 200
  • 300
  • 323 a.a.
Protein Preferred Names Protein Names

melanocortin receptor 3

  • MC3-R

Related Agents

  • Approval
  • Pre-clinical Phase

Approval

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-18678A Bremelanotide Acetate Agonist 99.97% Unkown
HY-18678 Bremelanotide Agonist 99.69% Unkown

Pre-clinical Phase

Bioactive Molecules (18)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P0267 Melanotan (MT)-II Agonist 99.97% Unkown
HY-P0227 SHU 9119 99.83% Unkown
HY-P0097A Nonapeptide-1 acetate salt Antagonist 95.58% Unkown
HY-P0097 Nonapeptide-1 Antagonist 98.74% Unkown
HY-147301 Resomelagon Agonist 98.79% Unkown
HY-P1531 γ-1-Melanocyte Stimulating Hormone (MSH), amide Agonist 97.03% Unkown
HY-P1214 γ1-MSH Agonist 99.60% Unkown
HY-P1217 [D-Trp8]-γ-MSH Agonist 98.25% Unkown
HY-19870C Setmelanotide monoacetate Agonist 99.81% Unkown
HY-P1209A PG106 TFA Antagonist 98.42% Unkown
HY-P4665 Ac-c[Cys-Glu-His-d-Phe-Arg-Trp-d-Cys]-Pro-Pro-Lys-Asp-NH2 Antagonist 98.14% Unkown
HY-P11469 PG-901 Modulator 99.35% Unkown
HY-168383 (E/Z)-Resomelagon acetate Agonist / Unkown
HY-P1214A γ1-MSH TFA Agonist / Unkown
HY-P0267A Melanotan (MT)-II acetate Agonist / Unkown
HY-111131 RY764 Agonist / Unkown
HY-P0252B α-MSH free acid Agonist / Unkown
HY-P1217A [D-Trp8]-γ-MSH TFA Agonist / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mc3r NCBI NCBI:4159