Glo1 - glyoxalase 1 Gene

Rattus norvegicus

Gene ID: 294320 | Gene type: protein coding

About Glo1

Primary_assembly 20: 8,662,801-8,681,649 reverse strand.mRatBN7.2:CM026993.1

This gene has 1 transcript (splice variant), 263 orthologues and is associated with 11 phenotypes. Biased expression in Muscle (RPKM 1139.), Heart (RPKM 642.4) and 9 other tissues.

Summary

Enables lactoylglutathione lyase activity. Involved in carbohydrate metabolic process; glutathione metabolic process; and methylglyoxal metabolic process. Predicted to be located in cytosol; nucleoplasm; and plasma membrane. Human ortholog(s) of this gene implicated in autistic disorder; diabetic retinopathy; end stage renal disease; type 2 diabetes mellitus; and vascular disease. Orthologous to human GLO1 (glyoxalase I). [provided by Alliance of Genome Resources, Apr 2022]

Glo1 Products(1)

mRNA	Protein	Name
NM_207594.3	NP_997477.1	lactoylglutathione lyase

Glo1 Protein Structure

PLN03042

0
100
184 a.a.

Protein Preferred Names

Protein Names

lactoylglutathione lyase

S-D-lactoylglutathione methylglyoxal lyase	aldoketomutase
glx I	glyoxalase I
glyoxylase 1	ketone-aldehyde mutase
methylglyoxalase

Related Agents

Pre-clinical Phase

Bioactive Molecules (10)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-136684	BrBzGCp2	Inhibitor	98.68%	Unkown
HY-15167A	Glyoxalase I inhibitor free base	Inhibitor	98.52%	Unkown
HY-146655	Glyoxalase I inhibitor 3	Inhibitor	98.06%	Unkown
HY-124824	Methyl gerfelin	Inhibitor	/	Unkown
HY-146653	Glyoxalase I inhibitor 1	Inhibitor	/	Unkown
HY-146654	Glyoxalase I inhibitor 2	Inhibitor	/	Unkown
HY-146657	4BAB	Inhibitor	/	Unkown
HY-RS05485	GLO1 Human Pre-designed siRNA Set A		/	Unkown
HY-RS05486	Glo1 Mouse Pre-designed siRNA Set A		/	Unkown
HY-RS05487	Glo1 Rat Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Glo1	NCBI	NCBI:2739
Mus musculus	Glo1	NCBI	NCBI:109801

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