Glo1 - glyoxalase 1 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 294320

About Glo1

Primary_assembly 20: 8,662,801-8,681,649 reverse strand.mRatBN7.2:CM026993.1

This gene has 1 transcript (splice variant), 263 orthologues and is associated with 11 phenotypes. Biased expression in Muscle (RPKM 1139.), Heart (RPKM 642.4) and 9 other tissues.

Summary

Enables lactoylglutathione lyase activity. Involved in carbohydrate metabolic process; glutathione metabolic process; and methylglyoxal metabolic process. Predicted to be located in cytosol; nucleoplasm; and plasma membrane. Human ortholog(s) of this gene implicated in autistic disorder; diabetic retinopathy; end stage renal disease; type 2 diabetes mellitus; and vascular disease. Orthologous to human GLO1 (glyoxalase I). [provided by Alliance of Genome Resources, Apr 2022]

Glo1 Products (1)

mRNA Protein Name
NM_207594.3 NP_997477.1 lactoylglutathione lyase

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables lactoylglutathione lyase activity IDA
IDA: Inferred from direct assay
8719777 RGD
Biological Process GO Annotation Evidence References Source
involved in glutathione metabolic process IDA
IDA: Inferred from direct assay
8719777 RGD
involved in methylglyoxal metabolic process IDA
IDA: Inferred from direct assay
8719777 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Glo1 Protein Structure

PLN03042

PLN03042: PLN03042 (19 - 183)

  • 0
  • 100
  • 184 a.a.
Protein Preferred Names Protein Names

lactoylglutathione lyase

  • S-D-lactoylglutathione methylglyoxal lyase

  • aldoketomutase

  • glx I

  • glyoxalase I

  • glyoxylase 1

  • ketone-aldehyde mutase

  • methylglyoxalase

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (12)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-136684 BrBzGCp2 Inhibitor 99.00% Unkown
HY-W001288 Indole-4-carboxaldehyde 99.85% Unkown
HY-34005 2-Dimethylaminophenol Inhibitor / Unkown
HY-146655 Glyoxalase I inhibitor 3 Inhibitor 98.06% Unkown
HY-124824 Methyl gerfelin Inhibitor 99.9% Unkown
HY-146653 Glyoxalase I inhibitor 1 Inhibitor / Unkown
HY-146654 Glyoxalase I inhibitor 2 Inhibitor / Unkown
HY-146657 4BAB Inhibitor / Unkown
HY-RS05485 GLO1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS05486 Glo1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS05487 Glo1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W001288S Indole-4-carboxaldehyde-13C / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Glo1 NCBI NCBI:2739