Limk2 - LIM domain kinase 2 Gene

Also Known as Link2; Limk2b

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 29524

About Limk2

Primary_assembly 14: 78,218,063-78,286,007 reverse strand.mRatBN7.2:CM026987.1

This gene has 3 transcripts (splice variants), 205 orthologues, 23 paralogues and is associated with 1 phenotype. Biased expression in Brain (RPKM 42.8), Liver (RPKM 38.3) and 9 other tissues.

Summary

Enables protein serine/threonine kinase activity. Involved in protein phosphorylation. Located in nucleus. Orthologous to human LIMK2 (LIM domain kinase 2). [provided by Alliance of Genome Resources, Apr 2022]

Limk2 Products (1)

mRNA Protein Name
NM_024135.2 NP_077049.2 LIM domain kinase 2

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein serine/threonine kinase activity IDA
IDA: Inferred from direct assay
7651734 RGD
Biological Process GO Annotation Evidence References Source
involved in protein phosphorylation IDA
IDA: Inferred from direct assay
7651734 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Limk2 Protein Structure

LIM

LIM: cl02475 (11 - 64)

LIM2_LIMK2

LIM2_LIMK2: cd09465 (66 - 124)

PDZ

PDZ: pfam00595 (151 - 235)

PKc_like

PKc_like: cl21453 (336 - 595)

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  • 600
  • 643 a.a.
Protein Preferred Names Protein Names

LIM domain kinase 2

  • LIM motif-containing protein kinase 2

  • LIMK-2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (16)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-18305 BMS-5 Inhibitor 99.84% Unkown
HY-18304 BMS-3 Inhibitor 99.89% Unkown
HY-122630 TH-257 Inhibitor 98.36% Unkown
HY-19352 T56-LIMKi Inhibitor 98.67% Unkown
HY-137346 DD-03-156 Degrader 99.90% Unkown
HY-120025 CRT0105950 Inhibitor 99.76% Unkown
HY-151539 TH470 Inhibitor 99.62% Unkown
HY-148063 DB0614 99.92% Unkown
HY-128062 LIMK1 inhibitor BMS-4 Inhibitor 99.1% Unkown
HY-14227 LIMK-IN-1 Inhibitor 99.33% Unkown
HY-174229 SM311 Inhibitor / Unkown
HY-175656 MDI-117740 Inhibitor / Unkown
HY-125444 TH251 Inhibitor / Unkown
HY-14226 LIMK-IN-3 Inhibitor / Unkown
HY-178122 THNAN69 Degrader / Unkown
HY-12659B LX7101 monohydrochloride Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Limk2 NCBI NCBI:3985