PRMT6 - protein arginine methyltransferase 6 Gene

Also Known as Hrmt1l6

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 295384

About PRMT6

Primary_assembly 2: 197,927,220-197,933,648 reverse strand.mRatBN7.2:CM026975.1

This gene has 1 transcript (splice variant), 166 orthologues, 10 paralogues and is associated with 2 phenotypes. Biased expression in Thymus (RPKM 33.4), Spleen (RPKM 33.1) and 9 other tissues.

Summary

Predicted to enable chromatin binding activity; histone binding activity; and protein-arginine N-methyltransferase activity. Predicted to be involved in negative regulation of nitrogen compound metabolic process; protein methylation; and regulation of mitochondrion organization. Predicted to act upstream of or within several processes, including cellular senescence; histone H3-R2 methylation; and negative regulation of nitrogen compound metabolic process. Predicted to be located in nucleolus and nucleoplasm. Orthologous to human PRMT6 (protein arginine methyltransferase 6). [provided by Alliance of Genome Resources, Apr 2022]

PRMT6 Products (2)

mRNA Protein Name
NM_001393859.1 NP_001380788.1 protein arginine N-methyltransferase 6
NM_001393858.1 NP_001380787.1 protein arginine N-methyltransferase 6

PRMT6 Protein Structure

AdoMet_MTases

AdoMet_MTases: cd02440 (84 - 184)

  • 0
  • 100
  • 200
  • 300
  • 375 a.a.
Protein Preferred Names Protein Names

protein arginine N-methyltransferase 6

  • HMT1 hnRNP methyltransferase-like 6

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-128717A GSK3368715 dihydrochloride Inhibitor 99.96% Phase 1
HY-128717B GSK3368715 trihydrochloride Inhibitor / Phase 1

Pre-clinical Phase

Bioactive Molecules (19)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-19615 MS023 Inhibitor 99.93% Unkown
HY-114965 TP-064 Inhibitor 99.29% Unkown
HY-12970 EPZ020411 Inhibitor 98.07% Unkown
HY-12970A EPZ020411 hydrochloride Inhibitor 98.15% Unkown
HY-128717 GSK3368715 Inhibitor 99.41% Unkown
HY-19615B MS023 dihydrochloride Inhibitor 99.68% Unkown
HY-141877 MS4322 Degrader 99.14% Unkown
HY-133740 MS117 Inhibitor 98.0% Unkown
HY-100360 MS049 Inhibitor 98.0% Unkown
HY-141877B MS4322 (isomer) 99.87% Unkown
HY-178114 SKLB-0124 Degrader / Unkown
HY-100565A SGC2085 hydrochloride Inhibitor / Unkown
HY-175821 PRMT1-IN-3 Inhibitor / Unkown
HY-186045 SKLB06489 Inhibitor / Unkown
HY-178274 SKLB06329 Inhibitor / Unkown
HY-12970B EPZ020411 dihydrochloride Inhibitor / Unkown
HY-161334 CARM1-IN-4 Inhibitor / Unkown
HY-146810 PRMT4-IN-1 Inhibitor / Unkown
HY-117927 EPZ0025654 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens PRMT6 NCBI NCBI:55170