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PRMT6 - protein arginine methyltransferase 6 Gene

Also Known as HRMT1L6

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 55170

About PRMT6

Cytogenetic location: 1p13.3 Genomic coordinates (GRCh38): 1:107,056,674-107,059,294 (from NCBI)

This gene has 3 transcripts (splice variants), 164 orthologues and 7 paralogues.

Summary

The protein encoded by this gene belongs to the arginine N-methyltransferase family, which catalyze the sequential transfer of methyl group from S-adenosyl-L-methionine to the side chain nitrogens of arginine residues within proteins, to form methylated arginine derivatives and S-adenosyl-L-homocysteine. This protein can catalyze both, the formation of omega-N monomethylarginine and asymmetrical dimethylarginine, with a strong preference for the latter. It specifically mediates the asymmetric dimethylation of Arg2 of histone H3, and the methylated form represents a specific tag for epigenetic transcriptional repression. This protein also forms a complex with, and methylates DNA Polymerase beta, resulting in stimulation of polymerase activity by enhancing DNA binding and processivity. [provided by RefSeq, Sep 2011]

PRMT6 Products (1)

mRNA	Protein	Name
NM_018137.3	NP_060607.2	protein arginine N-methyltransferase 6

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables histone H2AR3 methyltransferase activity	IDA IDA: Inferred from direct assay	18079182	GOA
enables histone H3 methyltransferase activity	EXP EXP: Inferred from Experiment	19509293	GOA
enables histone H3R2 methyltransferase activity	IDA IDA: Inferred from direct assay	17898714	GOA
enables histone H4R3 methyltransferase activity	IDA IDA: Inferred from direct assay	18079182	GOA
enables histone arginine N-methyltransferase activity	IDA IDA: Inferred from direct assay	23980157	GOA
enables histone binding	IDA IDA: Inferred from direct assay	17898714	GOA
enables histone methyltransferase activity	IDA IDA: Inferred from direct assay	19405910	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16157300	GOA
enables protein-arginine N-methyltransferase activity	IDA IDA: Inferred from direct assay	30420520	GOA
enables protein-arginine omega-N asymmetric methyltransferase activity	IDA IDA: Inferred from direct assay	11724789	GOA
enables protein-arginine omega-N monomethyltransferase activity	IDA IDA: Inferred from direct assay	11724789	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	18079182	GOA
involved in protein modification process	IDA IDA: Inferred from direct assay	30420520	GOA
involved in regulation of mitochondrion organization	IDA IDA: Inferred from direct assay	30420520	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in nucleus	IDA IDA: Inferred from direct assay	11724789	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PRMT6 Protein Structure

Methyltransf_18

0
100
200
300
375 a.a.

Protein Preferred Names	Protein Names
protein arginine N-methyltransferase 6	HMT1 hnRNP methyltransferase-like 6 heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 6 histone-arginine N-methyltransferase PRMT6

PRMT6 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	PRMT6	Q96LA8	a8k932_human	Homo sapiens	A8K932	Y2H Prey Pooling	25416956
Intra	PRMT6	Q96LA8	a8k932_human	Homo sapiens	A8K932	Validated Y2H	25416956
Intra	PRMT6	Q96LA8	CDCA4	Homo sapiens	Q9BXL8	Y2H	23455924
Intra	PRMT6	Q96LA8	SPSB1	Homo sapiens	Q96BD6	Y2H	23455924
Intra	PRMT6	Q96LA8	PCGF5	Homo sapiens	Q86SE9	Anti Tag CoIP	23455924
Intra	PRMT6	Q96LA8	PCGF5	Homo sapiens	Q86SE9	Y2H	23455924
Intra	PRMT6	Q96LA8	OAS1	Homo sapiens	P00973	Anti Tag CoIP	23455924
Intra	PRMT6	Q96LA8	OAS1	Homo sapiens	P00973	Y2H	23455924
Intra	PRMT6	Q96LA8	STARD10	Homo sapiens	Q9Y365	Anti Tag CoIP	23455924
Intra	PRMT6	Q96LA8	MED28	Homo sapiens	Q9H204	Anti Tag CoIP	23455924
Intra	PRMT6	Q96LA8	MED28	Homo sapiens	Q9H204	Y2H	23455924
Intra	PRMT6	Q96LA8	GTPBP2	Homo sapiens	Q9BX10	Y2H	23455924
Intra	PRMT6	Q96LA8	NR1D2	Homo sapiens	Q14995	Y2H	23455924
Intra	PRMT6	Q96LA8	NR1D2	Homo sapiens	Q14995	Anti Tag CoIP	23455924
Intra	PRMT6	Q96LA8	HMGA1	Homo sapiens	P17096-1	Far-WB	16293633
Intra	PRMT6	Q96LA8	HMGA1	Homo sapiens	P17096-1	Anti Bait CoIP	16293633
Intra	PRMT6	Q96LA8	HMGA1	Homo sapiens	P17096-1	Methyltransferase Ass	16293633
Intra	PRMT6	Q96LA8	HMGA1	Homo sapiens	P17096-1	Radiolabeled Methyl	16293633
Intra	PRMT6	Q96LA8	LOXL4	Homo sapiens	Q96JB6	Anti Tag CoIP	23455924
Intra	PRMT6	Q96LA8	C8orf74	Homo sapiens	Q6P047	Anti Tag CoIP	23455924
Intra	PRMT6	Q96LA8	GSTCD	Homo sapiens	Q8NEC7	Anti Tag CoIP	23455924
Intra	PRMT6	Q96LA8	KIF9	Homo sapiens	Q9HAQ2	Anti Tag CoIP	23455924
Intra	PRMT6	Q96LA8	HMGA2	Homo sapiens	P52926	Radiolabeled Methyl	16293633
Intra	PRMT6	Q96LA8	HMGA2	Homo sapiens	P52926	Far-WB	16293633
Intra	PRMT6	Q96LA8	RASSF2	Homo sapiens	P50749	Anti Tag CoIP	23455924
Intra	PRMT6	Q96LA8	RASSF2	Homo sapiens	P50749	Y2H	23455924

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant PRMT6 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P75983	PRMT6 Protein, Human (HEK293, His-Flag)	Q96LA8-1/NP_060607.2 (M1-D375)	≥ 95%, as determined by reducing SDS-PAGE.

PRMT6 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80875	PRMT6 Antibody (YA685)	WB, IHC-F, IHC-P, ICC/IF	Human
HY-P80875A	PRMT6 Antibody (YA685)(PBS only)	WB, IHC-F, IHC-P, ICC/IF	Human
HY-P85460	PRMT6 Antibody (YA5152)	WB, IHC-P, ICC/IF	Human, Mouse, Rat
HY-P85496	PRMT6 Antibody (YA5188)	WB, IHC-P, ICC/IF	Human

Related Diseases

Diseases	Alias
Male Infertility	Infertility, Male Infertility Male Male Sterility Absolute Infertility

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-128717A	GSK3368715 dihydrochloride	Inhibitor	99.96%	Phase 1
HY-128717B	GSK3368715 trihydrochloride	Inhibitor	/	Phase 1

Pre-clinical Phase

Bioactive Molecules (20)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-19615	MS023	Inhibitor	99.93%	Unkown
HY-114965	TP-064	Inhibitor	99.29%	Unkown
HY-12970	EPZ020411	Inhibitor	98.07%	Unkown
HY-12970A	EPZ020411 hydrochloride	Inhibitor	98.15%	Unkown
HY-128717	GSK3368715	Inhibitor	99.41%	Unkown
HY-19615B	MS023 dihydrochloride	Inhibitor	99.68%	Unkown
HY-141877	MS4322	Degrader	99.14%	Unkown
HY-133740	MS117	Inhibitor	98.0%	Unkown
HY-100360	MS049	Inhibitor	98.0%	Unkown
HY-141877B	MS4322 (isomer)		99.87%	Unkown
HY-178114	SKLB-0124	Degrader	/	Unkown
HY-161334	CARM1-IN-4	Inhibitor	/	Unkown
HY-175821	PRMT1-IN-3	Inhibitor	/	Unkown
HY-186045	SKLB06489	Inhibitor	/	Unkown
HY-178274	SKLB06329	Inhibitor	/	Unkown
HY-100565A	SGC2085 hydrochloride	Inhibitor	/	Unkown
HY-12970B	EPZ020411 dihydrochloride	Inhibitor	/	Unkown
HY-184653	MS3-123	Inhibitor	/	Unkown
HY-146810	PRMT4-IN-1	Inhibitor	/	Unkown
HY-117927	EPZ0025654	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	PRMT6	VGNC	VGNC:33351
Rattus norvegicus	PRMT6	RGD	RGD:1304701
Mus musculus	PRMT6	MGD	MGI:2139971
Canis familiaris	PRMT6	VGNC	VGNC:44999
Felis catus	PRMT6	VGNC	VGNC:64361
Macaca mulatta	PRMT6	VGNC	VGNC:76283
Others	PRMT6	NCBI