Gria3 - glutamate ionotropic receptor AMPA type subunit 3 Gene

Also Known as GLUR3; GluA3; GluR-3; GluR-C; GluR-K3

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 29628

Summary

Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes composed of multiple subunits, arranged to form ligand-gated ion channels. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. The subunit encoded by this gene belongs to a family of AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate)-sensitive glutamate receptors, and is subject to RNA editing (AGA->GGA; R->G). Alternative splicing at this locus results in different isoforms, which may vary in their signal transduction properties. [provided by RefSeq, Jul 2008]

Gria3 Products (2)

mRNA Protein Name
NM_001112742.1 NP_001106213.1 glutamate receptor 3 isoform 2 precursor
NM_032990.2 NP_116785.2 glutamate receptor 3 isoform 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables AMPA glutamate receptor activity IDA
IDA: Inferred from direct assay
11834304 RGD
enables amyloid-beta binding IPI
IPI: Inferred from physical interaction
20032460 RGD
enables glutamate-gated calcium ion channel activity IDA
IDA: Inferred from direct assay
1709304 RGD
enables glutamate-gated receptor activity IDA
IDA: Inferred from direct assay
1699567 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
9647694 RGD
Biological Process GO Annotation Evidence References Source
involved in regulation of receptor recycling IMP
IMP: Inferred from mutant phenotype
11348590 RGD
involved in response to fungicide IEP
IEP: Inferred from expression pattern
19591855 RGD
involved in response to lithium ion IEP
IEP: Inferred from expression pattern
15269270 RGD
Cellular Component GO Annotation Evidence References Source
part of AMPA glutamate receptor complex IDA
IDA: Inferred from direct assay
19265014 RGD
located in asymmetric synapse IDA
IDA: Inferred from direct assay
12077196 RGD
located in dendrite IDA
IDA: Inferred from direct assay
15844209 RGD
located in dendritic shaft IDA
IDA: Inferred from direct assay
12077196 RGD
located in dendritic spine IDA
IDA: Inferred from direct assay
11348590 RGD
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
12761821 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
12077196 RGD
located in perikaryon IDA
IDA: Inferred from direct assay
15844209 RGD
located in postsynaptic density IDA
IDA: Inferred from direct assay
10027300 RGD
is active in postsynaptic density membrane IDA
IDA: Inferred from direct assay
12761821 RGD
is active in postsynaptic membrane IDA
IDA: Inferred from direct assay
16903873 RGD
located in postsynaptic membrane IDA
IDA: Inferred from direct assay
25524891 RGD
is active in presynaptic active zone membrane IDA
IDA: Inferred from direct assay
12761821 RGD
is active in presynaptic membrane IDA
IDA: Inferred from direct assay
16903873 RGD
part of protein-containing complex IPI
IPI: Inferred from physical interaction
10027300 RGD
located in synaptic cleft IDA
IDA: Inferred from direct assay
17207780 RGD
located in terminal bouton IDA
IDA: Inferred from direct assay
15844209 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

glutamate receptor 3

  • AMPA-selective glutamate receptor 3

  • glutamate receptor, ionotrophic, AMPA 3

  • glutamate receptor, ionotropic, AMPA 3

  • glutamate receptor, ionotropic, AMPA3 (alpha 3)

Gria3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Gria3 P19492 Pick1 Rattus norvegicus Q9EP80
Y2H
10340301
Intra
Gria3 P19492 Pick1 Rattus norvegicus Q9EP80
Pull Down
11891216
Intra
Gria3 P19492 Pick1 Rattus norvegicus Q9EP80
Y2H
10027300
Intra
Gria3 P19492 Grip1 Rattus norvegicus P97879
Y2H
9647694
Intra
Gria3 P19492 Grip1 Rattus norvegicus P97879
Y2H
11891216
Intra
Gria3 P19492 Grip1 Rattus norvegicus P97879
Pull Down
11891216
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05793 GRIA3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Gria3 NCBI NCBI:2892