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Pick1 - protein interacting with PRKCA 1 Gene

Also Known as Prkcabp

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 84591

Summary

Enables several functions, including Arp2/3 complex binding activity; SNAP receptor activity; and signaling receptor binding activity. Involved in several processes, including dendritic spine maintenance; long-term synaptic depression; and regulation of receptor internalization. Located in several cellular components, including cytoplasmic vesicle; perinuclear region of cytoplasm; and postsynaptic density. Part of protein-containing complex. Is active in glutamatergic synapse and postsynaptic endocytic zone. Orthologous to human PICK1 (protein interacting with PRKCA 1). [provided by Alliance of Genome Resources, Apr 2022]

Pick1 Products (1)

mRNA	Protein	Name
NM_053460.2	NP_445912.2	PRKCA-binding protein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables Arp2/3 complex binding	IDA IDA: Inferred from direct assay	18297063	RGD
enables G protein-coupled glutamate receptor binding	IPI IPI: Inferred from physical interaction	11007882	RGD
enables G protein-coupled receptor binding	IPI IPI: Inferred from physical interaction	24749734	RGD
enables SNAP receptor activity	IDA IDA: Inferred from direct assay	11931741	RGD
enables actin filament binding	IDA IDA: Inferred from direct assay	18297063	RGD
enables cytoskeletal protein binding	IPI IPI: Inferred from physical interaction	18297063	RGD
enables identical protein binding	IDA IDA: Inferred from direct assay	10027300	RGD
enables identical protein binding	IPI IPI: Inferred from physical interaction	10027300	RGD
enables ionotropic glutamate receptor binding	IPI IPI: Inferred from physical interaction	11931741	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	10027300	RGD
enables protein domain specific binding	IMP IMP: Inferred from mutant phenotype	18032668	RGD
enables protein kinase C binding	IDA IDA: Inferred from direct assay	15774468	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in cellular response to decreased oxygen levels	IMP IMP: Inferred from mutant phenotype	23843614	RGD
involved in cellular response to glucose starvation	IMP IMP: Inferred from mutant phenotype	23843614	RGD
involved in dendritic spine maintenance	IMP IMP: Inferred from mutant phenotype	18297063	RGD
involved in dendritic spine organization	IDA IDA: Inferred from direct assay	21252856	RGD
involved in glial cell development	IMP IMP: Inferred from mutant phenotype	23843614	RGD
involved in long-term synaptic depression	IDA IDA: Inferred from direct assay	21252856	RGD
involved in negative regulation of Arp2/3 complex-mediated actin nucleation	IDA IDA: Inferred from direct assay	18297063	RGD
involved in negative regulation of gene expression	IMP IMP: Inferred from mutant phenotype	24749734	RGD
involved in positive regulation of receptor internalization	IDA IDA: Inferred from direct assay	18297063	RGD
involved in protein phosphorylation	IDA IDA: Inferred from direct assay	11237868	RGD
involved in receptor clustering	IMP IMP: Inferred from mutant phenotype	10027300	RGD
involved in regulation of kainate selective glutamate receptor activity	IMP IMP: Inferred from mutant phenotype	12597860	RGD
involved in regulation of postsynaptic neurotransmitter receptor internalization	IDA IDA: Inferred from direct assay	28855251	RGD
involved in regulation of postsynaptic neurotransmitter receptor internalization	IEP IEP: Inferred from expression pattern	28855251	RGD
involved in regulation of postsynaptic neurotransmitter receptor internalization	IMP IMP: Inferred from mutant phenotype	28855251	RGD

Cellular Component GO Annotation	Evidence	References	Source
located in dendrite	IDA IDA: Inferred from direct assay	18032668	RGD
located in dendritic spine	IDA IDA: Inferred from direct assay	11007883	RGD
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	19071197	RGD
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	28855251	RGD
located in neuron projection	IDA IDA: Inferred from direct assay	18297063	RGD
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	18032668	RGD
located in postsynaptic density	IDA IDA: Inferred from direct assay	10027300	RGD
is active in postsynaptic endocytic zone	IDA IDA: Inferred from direct assay	28855251	RGD
is active in postsynaptic endocytic zone	IMP IMP: Inferred from mutant phenotype	28855251	RGD
is active in postsynaptic specialization	IDA IDA: Inferred from direct assay	19071197	RGD
part of protein-containing complex	IDA IDA: Inferred from direct assay	10027300	RGD
located in synapse	IDA IDA: Inferred from direct assay	10027300	RGD
is active in synaptic vesicle	IDA IDA: Inferred from direct assay	19071197	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
PRKCA-binding protein	protein interacting with C kinase 1 protein kinase C-alpha-binding protein protein that interacts with C kinase 1

Pick1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Cross	Pick1	Q9EP80	GRIA2	Homo sapiens	P42262	FPS	20018661
Cross	Pick1	Q9EP80	GRIA2	Homo sapiens	P42262	FRET	20018661
Intra	Pick1	Q9EP80	mGluR7	Rattus norvegicus	Q63337	Y2H	11891216
Intra	Pick1	Q9EP80	Grm7	Rattus norvegicus	P35400	Anti Bait CoIP	11007882
Intra	Pick1	Q9EP80	Grm7	Rattus norvegicus	P35400	Pull Down	11007882
Intra	Pick1	Q9EP80	Gria2	Rattus norvegicus	P19491	Anti Bait CoIP	20018661
Intra	Pick1	Q9EP80	Gria2	Rattus norvegicus	P19491	Y2H	10340301
Intra	Pick1	Q9EP80	Gria2	Rattus norvegicus	P19491	IF	17914463
Intra	Pick1	Q9EP80	Gria2	Rattus norvegicus	P19491	CoIP	10340301
Intra	Pick1	Q9EP80	Gria2	Rattus norvegicus	P19491	Y2H	10027300
Intra	Pick1	Q9EP80	Gria2	Rattus norvegicus	P19491	IF	10027300
Intra	Pick1	Q9EP80	Gria2	Rattus norvegicus	P19491	Anti Bait CoIP	10027300
Intra	Pick1	Q9EP80	Gria2	Rattus norvegicus	P19491	Imaging	16055064
Intra	Pick1	Q9EP80	Pick1	Rattus norvegicus	Q9EP80	Imaging	16055064
Intra	Pick1	Q9EP80	Pick1	Rattus norvegicus	Q9EP80	SAXS	26073603
Intra	Pick1	Q9EP80	Pick1	Rattus norvegicus	Q9EP80	Solution Sedimentation	26073603
Intra	Pick1	Q9EP80	Pick1	Rattus norvegicus	Q9EP80	Anti Tag CoIP	16055064
Intra	Pick1	Q9EP80	Pick1	Rattus norvegicus	Q9EP80	Pull Down	16055064
Intra	Pick1	Q9EP80	Pick1	Rattus norvegicus	Q9EP80	FRET	26073603
Intra	Pick1	Q9EP80	Pick1	Rattus norvegicus	Q9EP80	GMS	26073603
Intra	Pick1	Q9EP80	Pick1	Rattus norvegicus	Q9EP80	Y2H	10027300
Intra	Pick1	Q9EP80	Pick1	Rattus norvegicus	Q9EP80	Crosslink	26073603
Intra	Pick1	Q9EP80	Gria3	Rattus norvegicus	P19492	Y2H	10340301
Intra	Pick1	Q9EP80	Gria3	Rattus norvegicus	P19492	Y2H	10027300
Intra	Pick1	Q9EP80	Gria3	Rattus norvegicus	P19492	Anti Bait CoIP	10027300
Intra	Pick1	Q9EP80	Gria3	Rattus norvegicus	P19492	Y2H	11891216
Intra	Pick1	Q9EP80	Btg2	Rattus norvegicus	P27049	Y2H	11237868
Intra	Pick1	Q9EP80	Btg2	Rattus norvegicus	P27049	CoIP	11237868

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P1056	pep2-SVKI	Inhibitor	/	Phase 1

Pre-clinical Phase

Bioactive Molecules (11)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-117772	FSC231	Inhibitor	99.51%	Unkown
HY-P1059	Pep2-AVKI	Inhibitor	/	Unkown
HY-180197	PICK1 PDZ-IN-1	Inhibitor	/	Unkown
HY-P1054	pep2-EVKI	Inhibitor	/	Unkown
HY-P1055	Pep2-SVKE	Control	/	Unkown
HY-P1057	Pep4c	Control	/	Unkown
HY-P2298	TAT-P4-(DATC5)2	Inhibitor	/	Unkown
HY-P2298A	TAT-P4-(DATC5)2 TFA		/	Unkown
HY-RS10479	PICK1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17204	Pick1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23656	Pick1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Pick1	NCBI	NCBI:9463