Grm7 - glutamate metabotropic receptor 7 Gene

Rattus norvegicus

Gene ID: 81672 | Gene type: protein coding

About Grm7

Primary_assembly 4: 143,731,259-144,612,344 forward strand.mRatBN7.2:CM026977.1

This gene has 2 transcripts (splice variants), 280 orthologues, 7 paralogues and is associated with 7 phenotypes. Restricted expression toward (RPKM 123.2).

Summary

Enables several functions, including PDZ domain binding activity; Calmodulin binding activity; and glutamate binding activity. Involved in adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway; negative regulation of glutamate secretion; and negative regulation of neuron apoptotic process. Located in several cellular components, including dendritic shaft; rough endoplasmic reticulum; and synaptic membrane. Part of protein-containing complex. Is active in GABA-ergic synapse and glutamatergic synapse. Is integral component of presynaptic active zone membrane. Orthologous to human GRM7 (glutamate metabotropic receptor 7). [provided by Alliance of Genome Resources, Apr 2022]

Grm7 Products(1)

mRNA	Protein	Name
NM_031040.1	NP_112302.1	metabotropic glutamate receptor 7 precursor

Grm7 Protein Structure

PBP1_mGluR_groupIII

NCD3G

7tmC_mGluR7

0
200
400
600
800
922 a.a.

Protein Preferred Names

Protein Names

metabotropic glutamate receptor 7

glutamate receptor, metabotropic 7	mGluR7
metabotropic glutamate receptor mGluR7	metabotropic glutamate receptor subtype 7b

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Purity	Rare Diseases
HY-RS05837	GRM7 Human Pre-designed siRNA Set A	/	Unkown
HY-RS05838	Grm7 Mouse Pre-designed siRNA Set A	/	Unkown
HY-RS05839	Grm7 Rat Pre-designed siRNA Set A	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Grm7	NCBI	NCBI:2917

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