Ulk2 - unc-51 like kinase 2 Gene

Also Known as Unc51.2; mKIAA0623; A830085I22Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 29869

About Ulk2

Chromosome 11: 61,666,475-61,745,899 reverse strand.GRCm39:CM001004.3

This gene has 3 transcripts (splice variants), 206 orthologues, 2 paralogues and is associated with 3 phenotypes. Ubiquitous expression in testis adult (RPKM 33.4), CNS E18 (RPKM 21.5) and 26 other tissues.

Summary

Enables protein serine/threonine kinase activity. Involved in Autophagy and response to starvation. Acts upstream of or within axon extension and negative regulation of collateral sprouting. Located in phagophore assembly site membrane. Is expressed in facial bone primordium; nervous system; and sensory organ. Orthologous to human ULK2 (unc-51 like Autophagy activating kinase 2). [provided by Alliance of Genome Resources, Apr 2022]

Ulk2 Products (1)

mRNA Protein Name
NM_013881.4 NP_038909.3 serine/threonine-protein kinase ULK2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
18443221 MGI
enables protein serine/threonine kinase activity IDA
IDA: Inferred from direct assay
18443221 MGI
Biological Process GO Annotation Evidence References Source
involved in autophagy IMP
IMP: Inferred from mutant phenotype
18443221 MGI
acts upstream of or within axon extension IMP
IMP: Inferred from mutant phenotype
17389358 MGI
acts upstream of or within axon guidance IMP
IMP: Inferred from mutant phenotype
29099309 MGI
acts upstream of collateral sprouting IMP
IMP: Inferred from mutant phenotype
17389358 MGI
acts upstream of or within negative regulation of collateral sprouting IMP
IMP: Inferred from mutant phenotype
17389358 MGI
acts upstream of or within protein localization IGI
IGI: Inferred from genetic interaction
29099309 MGI
involved in response to starvation IDA
IDA: Inferred from direct assay
18443221 MGI
acts upstream of or within somatic sensory system development IGI
IGI: Inferred from genetic interaction
29099309 MGI
Cellular Component GO Annotation Evidence References Source
located in phagophore assembly site membrane IDA
IDA: Inferred from direct assay
18443221 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Ulk2 Protein Structure

STKc_ULK2

STKc_ULK2: cd14201 (1 - 271)

DUF3543

DUF3543: cl13493 (842 - 1029)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1037 a.a.
Protein Preferred Names Protein Names

serine/threonine-protein kinase ULK2

  • serine/threonine-protein kinase Unc51.2

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-160699 DCC-3116 Inhibitor 99.84% Phase 2

Pre-clinical Phase

Bioactive Molecules (12)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-16966 SBI-0206965 Inhibitor 99.92% Unkown
HY-13018 MRT67307 Inhibitor 99.56% Unkown
HY-100006 MRT68921 Inhibitor 98.09% Unkown
HY-114490 ULK-101 Inhibitor 99.91% Unkown
HY-100006A MRT68921 dihydrochloride Inhibitor 99.67% Unkown
HY-137742 SBP-7455 Inhibitor 98.01% Unkown
HY-179089 SBP-1750 Inhibitor 98.05% Unkown
HY-13018A MRT67307 hydrochloride Inhibitor / Unkown
HY-162100 MR-2088 Inhibitor 99.50% Unkown
HY-181742 ULK1/2-IN-1 Inhibitor / Unkown
HY-181815 SBP-5147 Inhibitor / Unkown
HY-100006B MRT68921 hydrochloride Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ulk2 NCBI NCBI:9706