ULK2 - unc-51 like autophagy activating kinase 2 Gene

Also Known as ATG1B; Unc51.2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 9706

About ULK2

Cytogenetic location: 17p11.2 Genomic coordinates (GRCh38): 17:19,770,830-19,867,936 (from NCBI)

This gene has 11 transcripts (splice variants), 206 orthologues and 2 paralogues. Broad expression in testis (RPKM 16.5), brain (RPKM 7.4) and 21 other tissues.

Summary

This gene encodes a protein that is similar to a serine/threonine kinase in C. elegans which is involved in axonal elongation. The structure of this protein is similar to the C. elegans protein in that both proteins have an N-terminal kinase domain, a central proline/serine rich (PS) domain, and a C-terminal (C) domain. The gene is located within the Smith-Magenis syndrome region on chromosome 17. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Dec 2008]

ULK2 Products (5)

mRNA	Protein	Name
NM_001142610.2	NP_001136082.1	serine/threonine-protein kinase ULK2
XM_047437147.1	XP_047293103.1	serine/threonine-protein kinase ULK2 isoform X2
NM_014683.4	NP_055498.3	serine/threonine-protein kinase ULK2
XM_047437148.1	XP_047293104.1	serine/threonine-protein kinase ULK2 isoform X3
XM_017025425.3	XP_016880914.1	serine/threonine-protein kinase ULK2 isoform X1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	18936157	GOA
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	18936157	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in autophagy	IDA IDA: Inferred from direct assay	18936157	GOA
involved in autophagy	IGI IGI: Inferred from genetic interaction	28389568	GOA
involved in protein autophosphorylation	IDA IDA: Inferred from direct assay	18936157	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in phagophore assembly site membrane	IDA IDA: Inferred from direct assay	18936157	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ULK2 Protein Structure

Pkinase

DUF3543

0
200
400
600
800
1036 a.a.

Protein Preferred Names	Protein Names
serine/threonine-protein kinase ULK2

ULK2 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P84665	ULK2 Antibody (YA4362)	WB, FC, ELISA	Human, Mouse, Rat
HY-P84665A	ULK2 Antibody (YA4362)(PBS only)	WB, FC, ELISA	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Smith-Magenis Syndrome	SMS Chromosome 17p11.2 Deletion Syndrome 17p11.2 Microdeletion Syndrome 17p11.2 Monosomy Chromosome 17p Deletion Syndrome Del(17) P11.2 17p- Syndrome Deletion 17p Syndrome Partial Monosomy 17p

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-160699	DCC-3116	Inhibitor	99.84%	Phase 2

Pre-clinical Phase

Bioactive Molecules (12)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-16966	SBI-0206965	Inhibitor	99.92%	Unkown
HY-13018	MRT67307	Inhibitor	99.56%	Unkown
HY-100006	MRT68921	Inhibitor	98.09%	Unkown
HY-114490	ULK-101	Inhibitor	99.91%	Unkown
HY-100006A	MRT68921 dihydrochloride	Inhibitor	99.67%	Unkown
HY-137742	SBP-7455	Inhibitor	98.01%	Unkown
HY-179089	SBP-1750	Inhibitor	98.05%	Unkown
HY-13018A	MRT67307 hydrochloride	Inhibitor	/	Unkown
HY-162100	MR-2088	Inhibitor	99.50%	Unkown
HY-181742	ULK1/2-IN-1	Inhibitor	/	Unkown
HY-181815	SBP-5147	Inhibitor	/	Unkown
HY-100006B	MRT68921 hydrochloride	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	ULK2	VGNC	VGNC:78926
Felis catus	ULK2	VGNC	VGNC:66815
Mus musculus	ULK2	MGD	MGI:1352758
Rattus norvegicus	ULK2	RGD	RGD:1310181
Bos taurus	ULK2	VGNC	VGNC:36659
Canis familiaris	ULK2	VGNC	VGNC:48129
Others	ULK2	NCBI