2. Gene
  3. Parp3 - poly (ADP-ribose) polymerase family, member 3 Gene

Parp3 - poly (ADP-ribose) polymerase family, member 3 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as Adprtl3

Gene ID: 300985 | Gene type: protein coding

About Parp3

Primary_assembly 8: 107,111,012-107,116,782 reverse strand.mRatBN7.2:CM026981.1

This gene has 2 transcripts (splice variants), 198 orthologues and 2 paralogues. Biased expression in Heart (RPKM 112.7), Muscle (RPKM 1.4) and 9 other tissues.

Summary

Predicted to enable NAD DNA ADP-ribosyltransferase activity; NAD+ ADP-ribosyltransferase activity; and protein ADP-ribosylase activity. Predicted to be involved in DNA metabolic process; protein ADP-ribosylation; and regulation of DNA metabolic process. Predicted to act upstream of or within several processes, including positive regulation of DNA ligation; protein localization to site of double-strand break; and regulation of mitotic spindle organization. Predicted to be located in intercellular bridge and nuclear body. Predicted to be active in nucleolus and site of double-strand break. Orthologous to human PARP3 (poly(ADP-ribose) polymerase family member 3). [provided by Alliance of Genome Resources, Apr 2022]

Parp3 Products(1)

mRNA Protein Name
NM_001008328.1 NP_001008329.1 protein mono-ADP-ribosyltransferase PARP3

Parp3 Protein Structure

WGR

WGR: cl01581 (55 - 212)

parp_like

parp_like: cd01437 (238 - 588)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 590 a.a.
Protein Preferred Names Protein Names

protein mono-ADP-ribosyltransferase PARP3

ADP-ribosyltransferase (NAD+, poly (ADP-ribose polymerase)-like 3

poly (ADP-ribosyl) transferase-like 3

poly [ADP-ribose] polymerase 3

Related Agents

Approval
Bioactive Molecules (11)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-10619 Niraparib Inhibitor 99.96% Yes
HY-10617A Rucaparib Inhibitor 99.80% Yes
HY-10619B Niraparib tosylate Inhibitor 99.99% Yes
HY-10619A Niraparib hydrochloride Inhibitor 99.76% Yes
HY-10617 Rucaparib phosphate Inhibitor 99.76% Yes
HY-102003 Rucaparib monocamsylate Inhibitor 99.82% Yes
HY-10619E Niraparib tosylate hydrate Inhibitor 99.97% Yes
HY-10617C Rucaparib tartrate Inhibitor / Unkown
HY-102003A Rucaparib camsylate Inhibitor / Unkown
HY-10617D Rucaparib acetate Inhibitor / Unkown
HY-10617B Rucaparib hydrochloride Inhibitor / Unkown
Clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-13536 AZD-2461 Inhibitor 99.88% Phase 1
Pre-clinical Phase
Bioactive Molecules (6)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-150207 RBN-3143 Inhibitor 99.24% Unkown
HY-148566 OUL232 Inhibitor 99.82% Unkown
HY-148754 PARP10-IN-3 Inhibitor 98.89% Unkown
HY-148753 PARP10-IN-2 Inhibitor 98.02% Unkown
HY-155993 YCH1899 Inhibitor / Unkown
HY-W294889 OUL245 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Parp3 NCBI NCBI:10039