Fer - FER tyrosine kinase Gene

Also Known as Flk; Fert2; Flk_retired

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 301737

Summary

Enables several functions, including Cadherin binding activity; enzyme binding activity; and gamma-catenin binding activity. Predicted to be involved in several processes, including cell surface receptor signaling pathway; regulation of cell migration; and regulation of mast cell activation involved in immune response. Predicted to act upstream of or within protein autophosphorylation and signal transduction. Predicted to be located in cytosol and nucleus. Predicted to be extrinsic component of cytoplasmic side of plasma membrane. Predicted to colocalize with several cellular components, including chromatin; cytoskeleton; and lamellipodium. Orthologous to human FER (FER tyrosine kinase). [provided by Alliance of Genome Resources, Apr 2022]

Fer Products (2)

mRNA Protein Name
NM_001106928.1 NP_001100398.1 tyrosine-protein kinase Fer isoform 1
NM_001395758.1 NP_001382687.1 tyrosine-protein kinase Fer isoform 2

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
involved in Sertoli cell development IEP
IEP: Inferred from expression pattern
12700184 RGD
involved in adherens junction assembly IEP
IEP: Inferred from expression pattern
12700184 RGD
involved in adherens junction disassembly IEP
IEP: Inferred from expression pattern
12700184 RGD
involved in germ cell development IEP
IEP: Inferred from expression pattern
12700184 RGD
involved in male gonad development IEP
IEP: Inferred from expression pattern
12700184 RGD
involved in seminiferous tubule development IEP
IEP: Inferred from expression pattern
12700184 RGD
Cellular Component GO Annotation Evidence References Source
located in adherens junction IDA
IDA: Inferred from direct assay
12700184 RGD
part of protein-containing complex IDA
IDA: Inferred from direct assay
12700184 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

tyrosine-protein kinase Fer

  • c-FER

  • fer (fms/fps related) protein kinase, testis specific 2

  • fer (fps/fes related) tyrosine kinase

  • p94-FER

  • proto-oncogene c-Fer

  • proto-oncogene tyrosine-protein kinase FER

  • tyrosine protein kinase FLK

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (23)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-100579 Ferrostatin-1 Inhibitor 99.96% Unkown
HY-122844 Ifebemtinib Inhibitor 99.86% Unkown
HY-123919 TL13-112 Inhibitor 98.01% Unkown
HY-112097 E260 Inhibitor 99.92% Unkown
HY-147219A SIAIS164018 hydrochloride 98.06% Unkown
HY-122582 TL13-12 Degrader 98.16% Unkown
HY-128576 DS21360717 99.80% Unkown
HY-148061 DB1113 99.86% Unkown
HY-148063 DB0614 99.92% Unkown
HY-137343 DB-0646 Degrader 98.0% Unkown
HY-148066 DB0662 Degrader 99.66% Unkown
HY-P10229 RALF1 peptide Activator 98.69% Unkown
HY-136194 TL13-22 Inhibitor 99.71% Unkown
HY-147219 SIAIS164018 / Unkown
HY-156066 Ferrostatin-1 diyne Inhibitor 99.9% Unkown
HY-10338A Foretinib phosphate Inhibitor / Unkown
HY-125142 AP-24567 / Unkown
HY-136195 TL13-110 Inhibitor / Unkown
HY-161731 DS08701581 Inhibitor / Unkown
HY-RS04862 FER Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS04863 FER1L6 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS16564 Fer Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22996 Fer Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Fer NCBI NCBI:2241