TNKS2 - tankyrase 2 Gene

Rattus norvegicus

Gene ID: 309512 | Gene type: protein coding

About TNKS2

Primary_assembly 1: 234,567,858-234,621,079 forward strand.mRatBN7.2:CM026974.1

This gene has 2 transcripts (splice variants), 169 orthologues and 2 paralogues. Biased expression in Muscle (RPKM 716.3), Brain (RPKM 372.4) and 9 other tissues.

Summary

Enables protein N-terminus binding activity. Predicted to be involved in several processes, including protein ADP-ribosylation; protein localization to chromosome, telomeric region; and regulation of telomere maintenance. Predicted to act upstream of or within regulation of growth. Predicted to be located in nuclear envelope; pericentriolar material; and perinuclear region of cytoplasm. Predicted to be active in cytoplasm and nucleus. Orthologous to human TNKS2 (tankyrase 2). [provided by Alliance of Genome Resources, Apr 2022]

TNKS2 Products(1)

mRNA	Protein	Name
NM_001107607.2	NP_001101077.2	poly [ADP-ribose] polymerase tankyrase-2

TNKS2 Protein Structure

PTZ00322

ANK

PHA02876

ANK

PHA03095

ANK

SAM_tankyrase1,2

tankyrase_like

0
200
400
600
800
1000
1166 a.a.

Protein Preferred Names

Protein Names

poly [ADP-ribose] polymerase tankyrase-2

tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2

tankyrase-2-like

Related Agents

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-12418	Stenoparib	Inhibitor	≥98.0%	Phase 2

Pre-clinical Phase

Bioactive Molecules (28)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-15147	XAV-939	Inhibitor	99.91%	Unkown
HY-12438	G007-LK	Inhibitor	99.42%	Unkown
HY-13990	NVP-TNKS656		99.66%	Unkown
HY-12975	AZ6102	Inhibitor	99.65%	Unkown
HY-16910	WIKI4	Inhibitor	99.93%	Unkown
HY-19351	MN-64	Inhibitor	99.73%	Unkown
HY-U00422	K-756	Inhibitor	99.76%	Unkown
HY-145267	OM-153	Inhibitor	99.59%	Unkown
HY-101243	XMD16-5	Inhibitor	98.59%	Unkown
HY-123851	MSC2504877	Inhibitor	98.50%	Unkown
HY-15811	XMD8-87	Inhibitor	98.63%	Unkown
HY-121719	TIQ-A	Inhibitor	99.65%	Unkown
HY-143338	ART-IN-1	Inhibitor	98.91%	Unkown
HY-148061	DB1113		99.28%	Unkown
HY-147886	PARP1-IN-11	Inhibitor	98.58%	Unkown
HY-126248	Tankyrase-IN-2	Inhibitor	99.60%	Unkown
HY-145111	TNK2-IN-1	Inhibitor	/	Unkown
HY-145266	OM-1700	Inhibitor	/	Unkown
HY-146336	PARP1/2/TNKS1/2-IN-1		/	Unkown
HY-148065	FMF-06-098-1		/	Unkown
HY-153259	TNKS1/2-IN-2	Inhibitor	/	Unkown
HY-156332	TNKS-2-IN-2	Inhibitor	/	Unkown
HY-23338	TNKS-2-IN-1	Inhibitor	95.77%	Unkown
HY-RS14838	TNK2 Human Pre-designed siRNA Set A		/	Unkown
HY-RS14843	TNKS2 Human Pre-designed siRNA Set A		/	Unkown
HY-RS14844	Tnks2 Mouse Pre-designed siRNA Set A		/	Unkown
HY-RS14845	TNKS2 Rat Pre-designed siRNA Set A		/	Unkown
HY-153332	Tankyrase-IN-5	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	TNKS2	NCBI	NCBI:80351

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