TNKS2 - tankyrase 2 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 309512

About TNKS2

Primary_assembly 1: 234,567,858-234,621,079 forward strand.mRatBN7.2:CM026974.1

This gene has 2 transcripts (splice variants), 169 orthologues and 2 paralogues. Biased expression in Muscle (RPKM 716.3), Brain (RPKM 372.4) and 9 other tissues.

Summary

Enables protein N-terminus binding activity. Predicted to be involved in several processes, including protein ADP-ribosylation; protein localization to chromosome, telomeric region; and regulation of telomere maintenance. Predicted to act upstream of or within regulation of growth. Predicted to be located in nuclear envelope; pericentriolar material; and perinuclear region of cytoplasm. Predicted to be active in cytoplasm and nucleus. Orthologous to human TNKS2 (tankyrase 2). [provided by Alliance of Genome Resources, Apr 2022]

TNKS2 Products (1)

mRNA Protein Name
NM_001107607.2 NP_001101077.2 poly [ADP-ribose] polymerase tankyrase-2

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
27441654 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TNKS2 Protein Structure

PTZ00322

PTZ00322: cl31426 (26 - 112)

ANK

ANK: sd00045 (59 - 87)

PHA02876

PHA02876: cl31517 (72 - 457)

ANK

ANK: sd00045 (89 - 120)

ANK

ANK: sd00045 (122 - 153)

ANK

ANK: sd00045 (212 - 240)

ANK

ANK: sd00045 (242 - 273)

ANK

ANK: sd00045 (275 - 306)

ANK

ANK: sd00045 (364 - 396)

ANK

ANK: sd00045 (398 - 429)

ANK

ANK: sd00045 (432 - 520)

PHA03095

PHA03095: cl33707 (493 - 801)

ANK

ANK: sd00045 (527 - 555)

ANK

ANK: sd00045 (557 - 588)

ANK

ANK: sd00045 (590 - 621)

ANK

ANK: sd00045 (643 - 673)

ANK

ANK: sd00045 (680 - 708)

ANK

ANK: sd00045 (710 - 741)

ANK

ANK: sd00045 (743 - 774)

SAM_tankyrase1,2

SAM_tankyrase1,2: cd09524 (870 - 935)

tankyrase_like

tankyrase_like: cd01438 (937 - 1159)

  • 0
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  • 800
  • 1000
  • 1166 a.a.
Protein Preferred Names Protein Names

poly [ADP-ribose] polymerase tankyrase-2

  • tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2

  • tankyrase-2-like

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-12418 Stenoparib Inhibitor 98.0% Phase 2
HY-147245 Basroparib Inhibitor 98.91% Phase 1

Pre-clinical Phase

Bioactive Molecules (46)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-15147 XAV-939 Inhibitor 99.91% Unkown
HY-16910 WIKI4 Inhibitor 99.93% Unkown
HY-13990 NVP-TNKS656 99.68% Unkown
HY-12438 G007-LK Inhibitor 99.24% Unkown
HY-145267 OM-153 Inhibitor 99.30% Unkown
HY-123851 MSC2504877 Inhibitor 99.25% Unkown
HY-12975 AZ6102 Inhibitor 99.53% Unkown
HY-148065 FMF-06-098-1 Inhibitor 98.77% Unkown
HY-15811 XMD8-87 Inhibitor 99.57% Unkown
HY-19351 MN-64 Inhibitor 99.61% Unkown
HY-101243 XMD16-5 Inhibitor 98.20% Unkown
HY-148061 DB1113 99.86% Unkown
HY-U00422 K-756 Inhibitor 99.25% Unkown
HY-148063 DB0614 99.92% Unkown
HY-126248 Tankyrase-IN-2 99.06% Unkown
HY-147886 PARP1-IN-11 Inhibitor 99.42% Unkown
HY-121719 TIQ-A Inhibitor 99.85% Unkown
HY-156332 TNKS-2-IN-2 Inhibitor 99.47% Unkown
HY-164478 G-631 Inhibitor 99.88% Unkown
HY-12577 TNKS1/2-IN-1 Inhibitor 99.24% Unkown
HY-143338 ART-IN-1 Inhibitor 98.91% Unkown
HY-146336 PARP1/2/TNKS1/2-IN-1 98.66% Unkown
HY-173349 TDI-012804 Inhibitor / Unkown
HY-23338 TNKS-2-IN-1 Inhibitor 95.03% Unkown
HY-100847 AZ0108 Inhibitor / Unkown
HY-114943 TNKS-IN-1 Inhibitor 99.55% Unkown
HY-12601 TNKS 22 Inhibitor / Unkown
HY-12602 TNKS-IN-4 Inhibitor / Unkown
HY-13990G NVP-TNKS656 (GMP) / Unkown
HY-145111 TNK2-IN-1 Inhibitor / Unkown
HY-145266 OM-1700 Inhibitor / Unkown
HY-153259 TNKS1/2-IN-2 Inhibitor / Unkown
HY-156745 PROTAC DDa-1 Degrader / Unkown
HY-167762 TNKS-2-IN-4 Inhibitor / Unkown
HY-172747 TNKS-2-IN-3 Inhibitor / Unkown
HY-180926 PARP10-IN-4 Inhibitor / Unkown
HY-E70868 TNK1 Recombinant Human Active Protein Kinase / Unkown
HY-RS14838 TNK2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS14843 TNKS2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS14844 Tnks2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS14845 TNKS2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-153332 Tankyrase-IN-5 Inhibitor / Unkown
HY-168925 EXQ-2d Inhibitor / Unkown
HY-173480 TNKS-IN-3 Inhibitor / Unkown
HY-RS16928 Tnk2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23371 Tnk2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens TNKS2 NCBI NCBI:80351