Dock1 - dedicator of cytokinesis 1 Gene

Also Known as b2b3190Clo; 9130006G06Rik; D630004B07Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 330662

Summary

Predicted to enable SH3 domain binding activity. Predicted to contribute to guanyl-nucleotide exchange factor activity. Acts upstream of or within cell migration and hematopoietic progenitor cell differentiation. Predicted to be located in cytosol and nuclear speck. Predicted to be part of guanyl-nucleotide exchange factor complex. Is expressed in endocardial cushion and midgut vascular element. Used to study DiGeorge syndrome and tetralogy of Fallot. Orthologous to human DOCK1 (dedicator of cytokinesis 1). [provided by Alliance of Genome Resources, Apr 2022]

Dock1 Products (1)

mRNA Protein Name
NM_001033420.2 NP_001028592.1 dedicator of cytokinesis protein 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
15102471 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within cell migration IDA
IDA: Inferred from direct assay
15728191 MGI
acts upstream of or within hematopoietic progenitor cell differentiation IGI
IGI: Inferred from genetic interaction
24029230 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

dedicator of cytokinesis protein 1

  • 180 kDa protein downstream of CRK

  • DOCK180

  • dedicator of cyto-kinesis 1

Dock1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Dock1 Q8BUR4 Elmo1 Mus musculus Q8BPU7-1
Y2H
15102471
Intra
Dock1 Q8BUR4 Elmo3 Mus musculus Q8BYZ7
Y2H
15102471
Intra
Dock1 Q8BUR4 Zhx2 Mus musculus Q8C0C0
Y2H
15102471
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-136177 Tris(2,4-di-tert-butylphenyl)phosphate Inhibitor 99.81% Unkown
HY-124711 TBOPP Inhibitor 99.35% Unkown
HY-RS03921 DOCK1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20911 Dock1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27428 Dock1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Dock1 NCBI NCBI:1793