TMEM95 - transmembrane protein 95 Gene

Also Known as UNQ9390

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 339168

About TMEM95

Cytogenetic location: 17p13.1 Genomic coordinates (GRCh38): 17:7,355,156-7,357,219 (from NCBI)

This gene has 3 transcripts (splice variants), 1 gene allele and 88 orthologues. Biased expression in testis (RPKM 4.1), thyroid (RPKM 3.1) and 1 other tissue.

Summary

Predicted to be involved in fusion of sperm to egg plasma membrane involved in single fertilization. Predicted to be located in sperm plasma membrane. Predicted to be integral component of membrane. Predicted to be active in acrosomal membrane. [provided by Alliance of Genome Resources, Apr 2022]

TMEM95 Products (3)

mRNA Protein Name
NM_001320435.2 NP_001307364.1 sperm-egg fusion protein TMEM95 isoform 1 precursor
NM_001320436.2 NP_001307365.1 sperm-egg fusion protein TMEM95 isoform 3 precursor
NM_198154.3 NP_937797.1 sperm-egg fusion protein TMEM95 isoform 2 precursor

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TMEM95 Protein Structure

TMEM95

TMEM95: TMEM95 family (17 - 168)

  • 0
  • 100
  • 176 a.a.
Protein Preferred Names Protein Names

sperm-egg fusion protein TMEM95

TMEM95 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
TMEM95 Q3KNT9 CIB1 Homo sapiens Q99828
Y2H Prey Pooling
32296183
Intra
TMEM95 Q3KNT9 CIB1 Homo sapiens Q99828
Validated Y2H
32296183
Intra
TMEM95 Q3KNT9 CIB1 Homo sapiens Q99828
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Spermatogenic Failure

  • Azoospermia

  • Spgf

  • Spermatogenic Failure, Susceptibility To

  • Absent Sperm

  • Aspermatogenesis

  • Infertility Due To Azoospermia

  • Hypospermatogenesis

  • Azoospermatism
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14749 TMEM95 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta TMEM95 VGNC VGNC:79671
Bos taurus TMEM95 VGNC VGNC:106985
Rattus norvegicus TMEM95 RGD RGD:1593310
Mus musculus TMEM95 MGD MGI:3779488
Felis catus TMEM95 VGNC VGNC:66373
Others TMEM95 NCBI