EZHIP - EZH inhibitory protein Gene

Also Known as KIP75; CXorf67; CATACOMB

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 340602

About EZHIP

Cytogenetic location: Xp11.22 Genomic coordinates (GRCh38): X:51,406,948-51,408,843 (from NCBI)

This gene has 1 transcript (splice variant) and 64 orthologues.

Summary

Involved in negative regulation of histone H3-K27 methylation. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

EZHIP Products (1)

mRNA Protein Name
NM_203407.3 NP_981952.1 EZH inhibitory protein

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables histone methyltransferase inhibitor activity IDA
IDA: Inferred from direct assay
30923826 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
29909548 GOA
Biological Process GO Annotation Evidence References Source
involved in chromatin organization IDA
IDA: Inferred from direct assay
29909548 GOA
involved in epigenetic regulation of gene expression IDA
IDA: Inferred from direct assay
30923826 GOA
Cellular Component GO Annotation Evidence References Source
located in cytosol IDA
IDA: Inferred from direct assay
30923826 GOA
located in nucleus IDA
IDA: Inferred from direct assay
29909548 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

EZH inhibitory protein

  • K27M-like inhibitor of PRC2

EZHIP Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
EZHIP Q86X51 TRAF4 Homo sapiens Q9BUZ4
Validated Y2H
32296183
Intra
EZHIP Q86X51 TRIM41 Homo sapiens Q8WV44
Validated Y2H
32296183
Intra
EZHIP Q86X51 ZNF417 Homo sapiens Q8TAU3
Validated Y2H
32296183
Intra
EZHIP Q86X51 ENKD1 Homo sapiens Q9H0I2
Validated Y2H
32296183
Intra
EZHIP Q86X51 SCNM1 Homo sapiens Q9BWG6
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Posterior Fossa Ependymoma
Myxoid Leiomyosarcoma

  • Leiomyosarcoma, Myxoid
Central Nervous System Germ Cell Tumor

  • Central Nervous System Germ Cell Tumour

  • Germ Cell Tumor Of The Cns

  • Germ Cell Tumour Of The Cns
High Grade Ependymoma

  • Ependymal Neoplasm

  • Ependymal Tumors

  • Malignant Ependymoma

  • Ependymal Tumor

  • Anaplastic Ependymoma

  • Experimental Organism Malignant Ependymoma

  • Ependymoma Of Brain
Endometrial Stromal Nodule
Endometrial Stromal Tumor

  • Endometrial Stromal Neoplasm

  • Endometrial Stromal Tumors
Cerebral Ventricle Cancer

  • Cerebral Ventricle Neoplasms

  • Cerebral Ventricle Neoplasm

  • Intraventricular Tumor Of Brain
Supratentorial Ependymoma
Cerebrum Cancer

  • Cerebral Cancer

  • Neoplasm Of Cerebrum

  • Tumor Of Cerebrum

  • Malignant Neoplasm Of Cerebrum
Supratentorial Cancer

  • Supratentorial Neoplasms

  • Brain Neoplasm, Supratentorial

  • Malignant Supratentorial Tumor

  • Cancer, Supratentorial
Endometrial Stromal Sarcoma

  • Ess

  • Endometrial Stromal Sarcoma, High Grade

  • Undifferentiated Endometrial Sarcoma

  • Stromal Sarcoma Of The Corpus Uteri

  • Sarcoma Endometrial Stromal

  • Sarcoma, Endometrial Stromal

  • Undifferentiated Stromal Sarcoma
Cns Neuroblastoma With Foxr2 Activation

  • Central Nervous System Neuroblastoma With Foxr2 Activation

  • Cns Nb-Foxr2

  • Cns Neuroblastoma, Foxr2-Activated
Central Nervous System Neuroblastoma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04622 EZHIP Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus EZHIP RGD RGD:7681336
Mus musculus EZHIP MGD MGI:2147968
Macaca mulatta EZHIP VGNC VGNC:108075
Bos taurus EZHIP VGNC VGNC:108084