NUP43 - nucleoporin 43 Gene

Also Known as p42; bA350J20.1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 348995

About NUP43

Cytogenetic location: 6q25.1 Genomic coordinates (GRCh38): 6:149,724,315-149,749,358 (from NCBI)

This gene has 6 transcripts (splice variants) and 214 orthologues. Ubiquitous expression in lymph node (RPKM 6.0), appendix (RPKM 5.2) and 25 other tissues.

Summary

Bidirectional transport of macromolecules between the cytoplasm and nucleus occurs through nuclear pore complexes (NPCs) embedded in the nuclear envelope. NPCs are composed of subcomplexes, and NUP43 is part of one such subcomplex, Nup107-160 (Loiodice et al., 2004 [PubMed 15146057]).[supplied by OMIM, Mar 2008]

NUP43 Products (1)

mRNA Protein Name
NM_198887.3 NP_942590.1 nucleoporin Nup43

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
15146057 GOA
Cellular Component GO Annotation Evidence References Source
colocalizes with kinetochore IDA
IDA: Inferred from direct assay
15146057 GOA
located in nuclear envelope IDA
IDA: Inferred from direct assay
24315095 GOA
part of nuclear pore outer ring IDA
IDA: Inferred from direct assay
17360435 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NUP43 Protein Structure

WD40

WD40: WD domain, G-beta repeat (211 - 246)

WD40

WD40: WD domain, G-beta repeat (254 - 290)

  • 0
  • 100
  • 200
  • 300
  • 380 a.a.
Protein Preferred Names Protein Names

nucleoporin Nup43

  • nucleoporin 43kDa

NUP43 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
NUP43 Q8NFH3 PARK7 Homo sapiens Q99497
Validated Y2H
32814053
Intra
NUP43 Q8NFH3 PARK7 Homo sapiens Q99497
Y2H Pooling
32814053
Intra
NUP43 Q8NFH3 PARK7 Homo sapiens Q99497
Y2H Array
32814053
Intra
NUP43 Q8NFH3 LAMP2 Homo sapiens P13473-2
Y2H Pooling
32814053
Intra
NUP43 Q8NFH3 LAMP2 Homo sapiens P13473-2
Validated Y2H
32814053
Intra
NUP43 Q8NFH3 LAMP2 Homo sapiens P13473-2
Y2H Array
32814053
Intra
NUP43 Q8NFH3 PRPF40A Homo sapiens O75400-2
Y2H Pooling
32814053
Intra
NUP43 Q8NFH3 PRPF40A Homo sapiens O75400-2
Validated Y2H
32814053
Intra
NUP43 Q8NFH3 PRPF40A Homo sapiens O75400-2
Y2H Array
32814053
Intra
NUP43 Q8NFH3 CCK Homo sapiens P06307
Validated Y2H
32814053
Intra
NUP43 Q8NFH3 CCK Homo sapiens P06307
Y2H Array
32814053
Intra
NUP43 Q8NFH3 CCK Homo sapiens P06307
Y2H Pooling
32814053
Intra
NUP43 Q8NFH3 TTR Homo sapiens P02766
Y2H Array
32814053
Intra
NUP43 Q8NFH3 TTR Homo sapiens P02766
Y2H Pooling
32814053
Intra
NUP43 Q8NFH3 TTR Homo sapiens P02766
Validated Y2H
32814053
Intra
NUP43 Q8NFH3 HEXB Homo sapiens P07686
Y2H Array
32814053
Intra
NUP43 Q8NFH3 HEXB Homo sapiens P07686
Validated Y2H
32814053
Intra
NUP43 Q8NFH3 HEXB Homo sapiens P07686
Y2H Pooling
32814053
Intra
NUP43 Q8NFH3 CASP6 Homo sapiens P55212
Y2H Array
32814053
Intra
NUP43 Q8NFH3 CASP6 Homo sapiens P55212
Y2H Pooling
32814053
Intra
NUP43 Q8NFH3 CASP6 Homo sapiens P55212
Validated Y2H
32814053
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Familial Atrial Fibrillation

  • Atrial Fibrillation, Familial

  • Atfb

  • Atrial Fibrillation Autosomal Dominant

  • Autosomal Dominant Atrial Fibrillation

  • Auricular Fibrillation

  • Atrial Fibrillation

  • Atrial Fibrillation, Familial, 1
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09694 NUP43 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris NUP43 VGNC VGNC:44055
Bos taurus NUP43 VGNC VGNC:32361
Rattus norvegicus NUP43 RGD RGD:1596513
Mus musculus NUP43 MGD MGI:1917162
Macaca mulatta NUP43 VGNC VGNC:83438
Felis catus NUP43 VGNC VGNC:63926
Others NUP43 NCBI