DND1 - DND microRNA-mediated repression inhibitor 1 Gene

Also Known as RBMS4

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 373863

About DND1

Cytogenetic location: 5q31.3 Genomic coordinates (GRCh38): 5:140,670,794-140,673,576 (from NCBI)

This gene has 1 transcript (splice variant), 204 orthologues and 36 paralogues. Ubiquitous expression in testis (RPKM 7.3), colon (RPKM 6.1) and 25 other tissues.

Summary

This gene encodes a protein that binds to microRNA-targeting sequences of mRNAs, inhibiting microRNA-mediated repression. Reduced expression of this gene has been implicated in tongue squamous cell carcinoma. Two pseudogenes of this gene are located on the long arm of chromosome 17. [provided by RefSeq, Dec 2010]

DND1 Products (1)

mRNA Protein Name
NM_194249.3 NP_919225.1 dead end protein homolog 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables mRNA 3'-UTR binding IDA
IDA: Inferred from direct assay
18155131 GOA
NOT enables miRNA binding IDA
IDA: Inferred from direct assay
18155131 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Biological Process GO Annotation Evidence References Source
involved in 3'-UTR-mediated mRNA destabilization IDA
IDA: Inferred from direct assay
28297718 GOA
involved in negative regulation of miRNA-mediated gene silencing IDA
IDA: Inferred from direct assay
18155131 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
18155131 GOA
located in nucleus IDA
IDA: Inferred from direct assay
18155131 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DND1 Protein Structure

RRM_1

RRM_1: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (60 - 123)

DND1_DSRM

DND1_DSRM: double strand RNA binding domain from DEAD END PROTEIN 1 (254 - 332)

  • 0
  • 100
  • 200
  • 300
  • 353 a.a.
Protein Preferred Names Protein Names

dead end protein homolog 1

  • RNA-binding motif, single-stranded-interacting protein 4

DND1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
DND1 Q8IYX4 RBPMS2 Homo sapiens Q6ZRY4
Y2H Prey Pooling
32296183
Intra
DND1 Q8IYX4 RBPMS2 Homo sapiens Q6ZRY4
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Tongue Squamous Cell Carcinoma

  • Squamous Cell Carcinoma Of Tongue
Pharynx Squamous Cell Carcinoma
Male Infertility

  • Infertility, Male

  • Infertility Male

  • Male Sterility

  • Absolute Infertility
Testicular Disease

  • Testicular Dysfunction

  • Testicular Diseases

  • Disorder Of Testis

  • Testis Disorder

  • Testicular Disorders
Spermatocytoma

  • Spermatocytic Seminoma
Testicular Cancer

  • Testis Cancer

  • Testicular Carcinoma

  • Testicular Neoplasms

  • Malignant Neoplasm Of Testis

  • Childhood Neoplasm Of The Testis

  • Neoplasm Of Testis

  • Pediatric Testicular Neoplasm

  • Testicular Tumor

  • Testis Neoplasm

  • Testicular Tumors

  • Testicular Neoplasm

  • Testicular Malignant Germ Cell Tumor

  • Childhood Testicular Neoplasm

  • Carcinoma Of The Testis

  • Cancer Of Testis

  • Malignant Neoplasm Of Testis, Nos

  • Malignant Neoplasm Of Testis, Unspecified

  • Malignant Tumour Of Testis

  • Testicle Cancer

  • Primary Malignant Neoplasm Of Testis
Spermatogenic Failure

  • Azoospermia

  • Spgf

  • Spermatogenic Failure, Susceptibility To

  • Absent Sperm

  • Aspermatogenesis

  • Infertility Due To Azoospermia

  • Hypospermatogenesis

  • Azoospermatism
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03899 DND1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus DND1 VGNC VGNC:28138
Rattus norvegicus DND1 RGD RGD:1583648
Mus musculus DND1 MGD MGI:2447763
Macaca mulatta DND1 VGNC VGNC:110471
Canis familiaris DND1 VGNC VGNC:40028
Others DND1 NCBI