MICB - MHC class I polypeptide-related sequence B Gene

Homo sapiens

Also known as PERB11.2

Gene ID: 4277 | Gene type: protein coding

About MICB

Cytogenetic location: 6p21.33 Genomic coordinates (GRCh38): 6:31,494,918-31,511,124 (from NCBI)

This gene has 4 transcripts (splice variants), 1 gene allele, 405 orthologues and 22 paralogues. Broad expression in lymph node (RPKM 4.7), bone marrow (RPKM 4.2) and 20 other tissues.

Summary

This gene encodes a heavily glycosylated protein which is a ligand for the NKG2D type II receptor. Binding of the ligand activates the cytolytic response of natural killer (NK) cells, CD8 alphabeta T cells, and gammadelta T cells which express the receptor. This protein is stress-induced and is similar to MHC class I molecules; however, it does not associate with beta-2-microglobulin or bind Peptides. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

MICB Products(3)

mRNA	Protein	Name
NM_001289160.2	NP_001276089.1	MHC class I polypeptide-related sequence B isoform 2
NM_001289161.2	NP_001276090.1	MHC class I polypeptide-related sequence B isoform 3 precursor
NM_005931.5	NP_005922.2	MHC class I polypeptide-related sequence B isoform 1 precursor

MICB Protein Structure

MHC_I

C1-set

0
100
200
300
383 a.a.

Protein Preferred Names

Protein Names

MHC class I polypeptide-related sequence B

MHC class I antigen-related protein B

Recombinant MICB Proteins

Cat. No.	Product Name	Accession	Purity
HY-P72788	MICB Protein, Human	Q29980-1 (A23-G254,G39E)	≥95%
HY-P73293	MICB Protein, Human (HEK293, His-Fc)	Q29980 (M1-G298)	≥95%
HY-P73294	MICB Protein, Human (HEK293, His)	NP_005922.2 (A23-G298)	≥95%
HY-P78174	MICB Protein, Human (Biotinylated, HEK293, His-Avi)	Q29980 (A23-G298)	≥95%
HY-P78491	MICB Protein, Human (HEK293, His-Avi)	Q29980 (A23-G298)	≥95%
HY-P701023	MICB Protein, Human (HEK293, hFc)	Q29980-1 (A23-G298)	≥95%

Related Diseases

Diseases

Alias

Herpes Simplex

Herpes Simplex Infections	Herpesvirus Hominis Disease
Herpes Simplex Disease	Herpesviral Infection Due To Herpes Simplex
Infections Due To Simplex Virus	Herpes Nos

Rheumatoid Arthritis

RA	Arthritis, Rheumatoid
Rheumatoid Arthritis, Susceptibility To	Arthritis Or Polyarthritis, Rheumatic
Atrophic Arthritis	Rheumatism Arthritis
Rheumatoid Polyarthritis

Asymptomatic Dengue

Behcet Syndrome

Behcet Disease	Behcet'S Syndrome
Behcet'S Disease	Behçet Disease
Bd	Adamantiades-Behcet Disease
Triple Symptom Complex	Behçet'S Disease
Behet'S Syndrome	Bd Syndrome
Behçet Syndrome	Behçet'S Syndrome
Behcet Triple Symptom Complex	Malignant Aphthosis
Old Silk Route Disease	Adamantiades-Behçet Disease

Arthritis

Inflammatory Joint Disease

Inflammatory Disorder Of Joint

Celiac Disease 1

Celiac Disease	Coeliac Disease
Celiac Sprue	Celiac Disease, Susceptibility To
Gluten-Sensitive Enteropathy	Nontropical Sprue
Sprue	CELIAC1
Celiac Disease, Susceptibility To, 1	Celiac Sprue 1
Celiac Sprue, Susceptibility To, 1	Gluten-Sensitive Enteropathy 1
Gluten-Sensitive Enteropathy, Susceptibility To, 1	Idiopathic Steatorrhea
Cœliac Disease	Gluten Intolerance
Gluten-Induced Enteropathy	Gluten Enteropathy
Celiac Disease, Susceptibility To, Type 1	Childhood Celiac Disease
Coeliac Rickets	Gee Disease
Gee-Herter Disease	Heubner-Herter Disease
Idiopathic Steatorrhoea	Thaysen'S Disease
Herter Gee Syndrome

Schizophrenia

SCZD	Schizophrenia With Or Without An Affective Disorder
Schizophrenia 12	Schizophrenia, Susceptibility To
Schizophrenia-1	Dementia Praecox
Schizophrenia 1

Inflammatory Bowel Disease

Inflammatory Bowel Diseases

Bowel Disease, Inflammatory

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08430	MICB Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	MICB	MGD	MGI:2179989
Rattus norvegicus	MICB	RGD	RGD:1564508