MICB - MHC class I polypeptide-related sequence B Gene

Also Known as PERB11.2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 4277

About MICB

Cytogenetic location: 6p21.33 Genomic coordinates (GRCh38): 6:31,494,918-31,511,124 (from NCBI)

This gene has 4 transcripts (splice variants), 1 gene allele, 405 orthologues and 22 paralogues. Broad expression in lymph node (RPKM 4.7), bone marrow (RPKM 4.2) and 20 other tissues.

Summary

This gene encodes a heavily glycosylated protein which is a ligand for the NKG2D type II receptor. Binding of the ligand activates the cytolytic response of natural killer (NK) cells, CD8 alphabeta T cells, and gammadelta T cells which express the receptor. This protein is stress-induced and is similar to MHC class I molecules; however, it does not associate with beta-2-microglobulin or bind peptides. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

MICB Products (3)

mRNA Protein Name
NM_001289160.2 NP_001276089.1 MHC class I polypeptide-related sequence B isoform 2
NM_001289161.2 NP_001276090.1 MHC class I polypeptide-related sequence B isoform 3 precursor
NM_005931.5 NP_005922.2 MHC class I polypeptide-related sequence B isoform 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables natural killer cell lectin-like receptor binding IDA
IDA: Inferred from direct assay
11491531 GOA
Biological Process GO Annotation Evidence References Source
involved in gamma-delta T cell activation IDA
IDA: Inferred from direct assay
9497295 GOA
involved in immune response-activating cell surface receptor signaling pathway IDA
IDA: Inferred from direct assay
11491531 GOA
involved in negative regulation of defense response to virus by host IDA
IDA: Inferred from direct assay
11239445 GOA
involved in response to heat IDA
IDA: Inferred from direct assay
9497295 GOA
involved in response to oxidative stress IDA
IDA: Inferred from direct assay
11287116 GOA
involved in response to retinoic acid IDA
IDA: Inferred from direct assay
12569559 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MICB Protein Structure

MHC_I

MHC_I: Class I Histocompatibility antigen, domains alpha 1 and 2 (25 - 198)

C1-set

C1-set: Immunoglobulin C1-set domain (218 - 290)

  • 0
  • 100
  • 200
  • 300
  • 383 a.a.
Protein Preferred Names Protein Names

MHC class I polypeptide-related sequence B

  • MHC class I antigen-related protein B

Recombinant MICB Proteins

Cat. No. Product Name Accession Purity
HY-P73293 MICB Protein, Human (HEK293, His-Fc) Q29980-1/NP_005922.2 (A23-G298) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P73294 MICB Protein, Human (HEK293, His) NP_005922.2 (A23-G298) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P78174 MICB Protein, Human (Biotinylated, HEK293, His-Avi) Q29980-1 (A23-G298) ≥ 95%, as determined by Bis-Tris PAGE.
HY-P78491 MICB Protein, Human (HEK293, His-Avi) Q29980-1 (A23-G298) ≥ 95%, as determined by Bis-Tris PAGE.
HY-P701023 MICB Protein, Human (HEK293, hFc) Q29980-1 (A23-G298) ≥ 95%, as determined by reducing SDS-PAGE.

MICB Antibodies

Cat. No. Product Name Application Reactivity
HY-P811307 MICB Antibody WB Human, Mouse, Rat
HY-P81721 MICB Antibody (YA1466) FC, ELISA Human
HY-P83760 MICA+MICB Antibody (YA3560) WB, IP, FC Human

Related Diseases

Diseases Alias
Herpes Simplex

  • Herpes Simplex Infections

  • Herpesvirus Hominis Disease

  • Herpes Simplex Disease

  • Herpesviral Infection Due To Herpes Simplex

  • Infections Due To Simplex Virus

  • Herpes Nos
Rheumatoid Arthritis

  • RA

  • Arthritis, Rheumatoid

  • Rheumatoid Arthritis, Susceptibility To

  • Arthritis Or Polyarthritis, Rheumatic

  • Atrophic Arthritis

  • Rheumatism Arthritis

  • Rheumatoid Polyarthritis
Asymptomatic Dengue
Behcet Syndrome

  • Behcet Disease

  • Behcet'S Syndrome

  • Behcet'S Disease

  • Behçet Disease

  • Bd

  • Adamantiades-Behcet Disease

  • Triple Symptom Complex

  • Behçet'S Disease

  • Behet'S Syndrome

  • Bd Syndrome

  • Behçet Syndrome

  • Behçet'S Syndrome

  • Behcet Triple Symptom Complex

  • Malignant Aphthosis

  • Old Silk Route Disease

  • Adamantiades-Behçet Disease
Arthritis

  • Inflammatory Joint Disease

  • Inflammatory Disorder Of Joint
Celiac Disease 1

  • Celiac Disease

  • Coeliac Disease

  • Celiac Sprue

  • Celiac Disease, Susceptibility To

  • Gluten-Sensitive Enteropathy

  • Nontropical Sprue

  • Sprue

  • CELIAC1

  • Celiac Disease, Susceptibility To, 1

  • Celiac Sprue 1

  • Celiac Sprue, Susceptibility To, 1

  • Gluten-Sensitive Enteropathy 1

  • Gluten-Sensitive Enteropathy, Susceptibility To, 1

  • Idiopathic Steatorrhea

  • Cœliac Disease

  • Gluten Intolerance

  • Gluten-Induced Enteropathy

  • Gluten Enteropathy

  • Celiac Disease, Susceptibility To, Type 1

  • Childhood Celiac Disease

  • Coeliac Rickets

  • Gee Disease

  • Gee-Herter Disease

  • Heubner-Herter Disease

  • Idiopathic Steatorrhoea

  • Thaysen'S Disease

  • Herter Gee Syndrome
Schizophrenia

  • SCZD

  • Schizophrenia With Or Without An Affective Disorder

  • Schizophrenia 12

  • Schizophrenia, Susceptibility To

  • Schizophrenia-1

  • Dementia Praecox

  • Schizophrenia 1
Inflammatory Bowel Disease

  • Inflammatory Bowel Diseases

  • Bowel Disease, Inflammatory
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-101780A Tinostamustine hydrochloride Inhibitor / Unkown
HY-RS08430 MICB Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23997 Micb Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P99389 Tesnatilimab 99.80% Unkown
HY-P990467 Anti-MICB Antibody Inhibitor ≥99.0% Unkown
HY-P992391 IPH4301 / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus MICB MGD MGI:2179989
Rattus norvegicus MICB RGD RGD:1564508