MLLT6 - MLLT6, PHD finger containing Gene

Also Known as AF17

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 4302

About MLLT6

Cytogenetic location: 17q12 Genomic coordinates (GRCh38): 17:38,705,273-38,729,795 (from NCBI)

This gene has 11 transcripts (splice variants), 1 gene allele, 192 orthologues, 8 paralogues and is associated with 1 phenotype. Ubiquitous expression in spleen (RPKM 30.7), ovary (RPKM 26.5) and 25 other tissues.

Summary

Enables histone binding activity and nucleosome binding activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to act upstream of or within several processes, including negative regulation of histone H3-K79 methylation; renal potassium excretion; and renal sodium excretion. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]

MLLT6 Products (1)

mRNA	Protein	Name
NM_005937.4	NP_005928.2	protein AF-17

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables histone binding	IPI IPI: Inferred from physical interaction	26439302	GOA
enables nucleosome binding	IDA IDA: Inferred from direct assay	26439302	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MLLT6 Protein Structure

PHD_2

zf-HC5HC2H_2

0
200
400
600
800
1000
1093 a.a.

Protein Preferred Names	Protein Names
protein AF-17	ALL1-fused gene from chromosome 17 protein

MLLT6 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	MLLT6	P55198	UBQLN1	Homo sapiens	Q9UMX0-2	Y2H Prey Pooling	25416956
Intra	MLLT6	P55198	CREB5	Homo sapiens	Q02930-3	Validated Y2H	32296183
Intra	MLLT6	P55198	TLE5	Homo sapiens	Q08117-2	Validated Y2H	32296183
Intra	MLLT6	P55198	ATXN10	Homo sapiens	Q9UBB4	Y2H Array	32814053
Intra	MLLT6	P55198	ATXN10	Homo sapiens	Q9UBB4	Validated Y2H	32814053
Intra	MLLT6	P55198	ATXN10	Homo sapiens	Q9UBB4	Y2H Pooling	32814053
Intra	MLLT6	P55198	UBQLN4	Homo sapiens	Q9NRR5	Pull Down	16713569
Intra	MLLT6	P55198	UBQLN4	Homo sapiens	Q9NRR5	Y2H Array	16713569
Intra	MLLT6	P55198	PIN1	Homo sapiens	Q13526	Validated Y2H	32296183
Intra	MLLT6	P55198	GRIPAP1	Homo sapiens	Q4V328	Validated Y2H	32296183
Intra	MLLT6	P55198	CEBPG	Homo sapiens	P53567	Anti Tag CoIP	28514442
Intra	MLLT6	P55198	CEBPG	Homo sapiens	P53567	Anti Tag CoIP	33961781
Intra	MLLT6	P55198	ZMYND19	Homo sapiens	Q96E35	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

MLLT6 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P83328	MLLT6 Antibody (YA3073)	WB	Human
HY-P83328A	MLLT6 Antibody (YA3073)(PBS only)	WB	Human

Related Diseases

Diseases	Alias
Acute Megakaryoblastic Leukemia Without Down Syndrome	Non-Ds-Amkl
Pineal Region Germinoma	Pineal Germinoma
Liddle Syndrome 1	Liddle Syndrome Pseudoaldosteronism Liddle'S Syndrome LIDLS1 Lidls Pseudohyperaldosteronism Pseudoprimary Hyperaldosteronism Pseudohyperaldosteronism Type 1 Liddles Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08497	MLLT6 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	MLLT6	MGD	MGI:1935145
Felis catus	MLLT6	VGNC	VGNC:68273
Canis familiaris	MLLT6	VGNC	VGNC:43263
Bos taurus	MLLT6	VGNC	VGNC:31504
Macaca mulatta	MLLT6	VGNC	VGNC:74883
Rattus norvegicus	MLLT6	RGD	RGD:1306689
Others	MLLT6	NCBI