ASGR1 - asialoglycoprotein receptor 1 Gene

Also Known as HL-1; ASGPR; ASGPR1; CLEC4H1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 432

About ASGR1

Cytogenetic location: 17p13.1 Genomic coordinates (GRCh38): 17:7,173,431-7,179,370 (from NCBI)

This gene has 9 transcripts (splice variants), 155 orthologues and 14 paralogues. Biased expression in liver (RPKM 145.0) and testis (RPKM 4.7).

Summary

This gene encodes a subunit of the asialoglycoprotein receptor. This receptor is a transmembrane protein that plays a critical role in serum glycoprotein homeostasis by mediating the endocytosis and lysosomal degradation of glycoproteins with exposed terminal galactose or N-acetylgalactosamine residues. The asialoglycoprotein receptor may facilitate hepatic Infection by multiple viruses including hepatitis B, and is also a target for liver-specific drug delivery. The asialoglycoprotein receptor is a hetero-oligomeric protein composed of major and minor subunits, which are encoded by different genes. The protein encoded by this gene is the more abundant major subunit. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]

ASGR1 Products (2)

mRNA	Protein	Name
NM_001197216.3	NP_001184145.1	asialoglycoprotein receptor 1 isoform b
NM_001671.5	NP_001662.1	asialoglycoprotein receptor 1 isoform a

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	21988832	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ASGR1 Protein Structure

Lectin_N

Lectin_C

0
100
200
291 a.a.

Protein Preferred Names	Protein Names
asialoglycoprotein receptor 1	C-type lectin domain family 4 member H1

ASGR1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	ASGR1	P07306	CYB5R3	Homo sapiens	P00387	Y2H Prey Pooling	32296183
Intra	ASGR1	P07306	CYB5R3	Homo sapiens	P00387	Y2H Array	32296183
Intra	ASGR1	P07306	CERS2	Homo sapiens	Q96G23	Y2H	21988832
Intra	ASGR1	P07306	SPAG4	Homo sapiens	Q9NPE6	Y2H Prey Pooling	32296183
Intra	ASGR1	P07306	SPAG4	Homo sapiens	Q9NPE6	Validated Y2H	32296183
Intra	ASGR1	P07306	SPAG4	Homo sapiens	Q9NPE6	Y2H Array	32296183
Intra	ASGR1	P07306	NEMP1	Homo sapiens	O14524-2	Y2H Array	32296183
Intra	ASGR1	P07306	NEMP1	Homo sapiens	O14524-2	Y2H Prey Pooling	32296183
Intra	ASGR1	P07306	HIBADH	Homo sapiens	P31937	Validated Y2H	32296183
Intra	ASGR1	P07306	HIBADH	Homo sapiens	P31937	Y2H Array	32296183
Intra	ASGR1	P07306	HIBADH	Homo sapiens	P31937	Y2H Prey Pooling	32296183
Intra	ASGR1	P07306	GPX8	Homo sapiens	Q8TED1	Y2H Prey Pooling	32296183
Intra	ASGR1	P07306	GPX8	Homo sapiens	Q8TED1	Validated Y2H	32296183
Intra	ASGR1	P07306	GPX8	Homo sapiens	Q8TED1	Y2H Array	32296183
Intra	ASGR1	P07306	AHNAK2	Homo sapiens	Q8IVF2-3	Y2H Prey Pooling	32296183
Intra	ASGR1	P07306	AHNAK2	Homo sapiens	Q8IVF2-3	Y2H Array	32296183
Intra	ASGR1	P07306	AHNAK2	Homo sapiens	Q8IVF2-3	Validated Y2H	32296183
Intra	ASGR1	P07306	FNDC9	Homo sapiens	Q8TBE3	Validated Y2H	32296183
Intra	ASGR1	P07306	FNDC9	Homo sapiens	Q8TBE3	Y2H Prey Pooling	32296183
Intra	ASGR1	P07306	FNDC9	Homo sapiens	Q8TBE3	Y2H Array	32296183
Intra	ASGR1	P07306	ATP1B4	Homo sapiens	Q9UN42	Y2H Prey Pooling	32296183
Intra	ASGR1	P07306	ATP1B4	Homo sapiens	Q9UN42	Validated Y2H	32296183
Intra	ASGR1	P07306	ATP1B4	Homo sapiens	Q9UN42	Y2H Array	32296183
Intra	ASGR1	P07306	SLC35C2	Homo sapiens	Q9NQQ7-3	Validated Y2H	32296183
Intra	ASGR1	P07306	SLC35C2	Homo sapiens	Q9NQQ7-3	Y2H Array	32296183
Intra	ASGR1	P07306	SLC35C2	Homo sapiens	Q9NQQ7-3	Y2H Prey Pooling	32296183
Intra	ASGR1	P07306	LEUTX	Homo sapiens	A8MZ59	Y2H Array	32296183
Intra	ASGR1	P07306	LEUTX	Homo sapiens	A8MZ59	Y2H Prey Pooling	32296183
Intra	ASGR1	P07306	CPLX4	Homo sapiens	Q7Z7G2	Validated Y2H	32296183
Intra	ASGR1	P07306	CPLX4	Homo sapiens	Q7Z7G2	Y2H Array	32296183
Intra	ASGR1	P07306	CPLX4	Homo sapiens	Q7Z7G2	Y2H Prey Pooling	32296183
Intra	ASGR1	P07306	SUSD3	Homo sapiens	Q96L08	Y2H Array	32296183
Intra	ASGR1	P07306	SUSD3	Homo sapiens	Q96L08	Y2H Prey Pooling	32296183
Intra	ASGR1	P07306	SUSD3	Homo sapiens	Q96L08	Validated Y2H	32296183
Intra	ASGR1	P07306	FAM209A	Homo sapiens	Q5JX71	Y2H Array	32296183
Intra	ASGR1	P07306	FAM209A	Homo sapiens	Q5JX71	Y2H Prey Pooling	32296183
Intra	ASGR1	P07306	FAM209A	Homo sapiens	Q5JX71	Validated Y2H	32296183
Intra	ASGR1	P07306	AMIGO1	Homo sapiens	Q86WK6	Validated Y2H	32296183
Intra	ASGR1	P07306	AMIGO1	Homo sapiens	Q86WK6	Y2H Array	32296183
Intra	ASGR1	P07306	AMIGO1	Homo sapiens	Q86WK6	Y2H Prey Pooling	32296183
Intra	ASGR1	P07306	RNF19B	Homo sapiens	Q6ZMZ0	Validated Y2H	32296183
Intra	ASGR1	P07306	RNF19B	Homo sapiens	Q6ZMZ0	Y2H Array	32296183
Intra	ASGR1	P07306	RNF19B	Homo sapiens	Q6ZMZ0	Y2H Prey Pooling	32296183
Intra	ASGR1	P07306	APH1A	Homo sapiens	Q96BI3	Validated Y2H	32296183
Intra	ASGR1	P07306	APH1A	Homo sapiens	Q96BI3	Y2H Array	32296183
Intra	ASGR1	P07306	APH1A	Homo sapiens	Q96BI3	Y2H Prey Pooling	32296183
Intra	ASGR1	P07306	MCEMP1	Homo sapiens	Q8IX19	Validated Y2H	32296183
Intra	ASGR1	P07306	MCEMP1	Homo sapiens	Q8IX19	Y2H Array	32296183
Intra	ASGR1	P07306	MCEMP1	Homo sapiens	Q8IX19	Y2H Prey Pooling	32296183
Intra	ASGR1	P07306	FCGR1A	Homo sapiens	P12314	Y2H Array	32296183
Intra	ASGR1	P07306	FCGR1A	Homo sapiens	P12314	Y2H Prey Pooling	32296183
Intra	ASGR1	P07306	FCGR1A	Homo sapiens	P12314	Validated Y2H	32296183
Intra	ASGR1	P07306	BLCAP	Homo sapiens	P62952	Y2H Prey Pooling	32296183
Intra	ASGR1	P07306	BLCAP	Homo sapiens	P62952	Validated Y2H	32296183
Intra	ASGR1	P07306	BLCAP	Homo sapiens	P62952	Y2H Array	32296183
Intra	ASGR1	P07306	SAR1A	Homo sapiens	Q9NR31	Y2H Prey Pooling	32296183
Intra	ASGR1	P07306	SAR1A	Homo sapiens	Q9NR31	Validated Y2H	32296183
Intra	ASGR1	P07306	SAR1A	Homo sapiens	Q9NR31	Y2H Array	32296183
Intra	ASGR1	P07306	SLC10A1	Homo sapiens	Q14973	Validated Y2H	32296183
Intra	ASGR1	P07306	SLC10A1	Homo sapiens	Q14973	Y2H Array	32296183
Intra	ASGR1	P07306	SLC10A1	Homo sapiens	Q14973	Y2H Prey Pooling	32296183
Intra	ASGR1	P07306	TMX2	Homo sapiens	Q9Y320	Validated Y2H	32296183
Intra	ASGR1	P07306	TMX2	Homo sapiens	Q9Y320	Y2H Prey Pooling	32296183
Intra	ASGR1	P07306	TMX2	Homo sapiens	Q9Y320	Y2H Array	32296183
Intra	ASGR1	P07306	CREB3L1	Homo sapiens	Q96BA8	Validated Y2H	32296183
Intra	ASGR1	P07306	CREB3L1	Homo sapiens	Q96BA8	Y2H Array	32296183
Intra	ASGR1	P07306	CREB3L1	Homo sapiens	Q96BA8	Y2H Prey Pooling	32296183
Intra	ASGR1	P07306	PDZK1IP1	Homo sapiens	Q13113	Y2H Array	32296183
Intra	ASGR1	P07306	PDZK1IP1	Homo sapiens	Q13113	Validated Y2H	32296183
Intra	ASGR1	P07306	PDZK1IP1	Homo sapiens	Q13113	Y2H Prey Pooling	32296183
Intra	ASGR1	P07306	IGFBP5	Homo sapiens	P24593	Validated Y2H	32296183
Intra	ASGR1	P07306	CLDN7	Homo sapiens	O95471	Y2H Prey Pooling	32296183
Intra	ASGR1	P07306	CLDN7	Homo sapiens	O95471	Y2H Array	32296183
Intra	ASGR1	P07306	VSIR	Homo sapiens	Q9H7M9	Y2H Prey Pooling	32296183
Intra	ASGR1	P07306	VSIR	Homo sapiens	Q9H7M9	Validated Y2H	32296183
Intra	ASGR1	P07306	VSIR	Homo sapiens	Q9H7M9	Y2H Array	32296183
Intra	ASGR1	P07306	ERGIC3	Homo sapiens	Q9Y282	Validated Y2H	32296183
Intra	ASGR1	P07306	ERGIC3	Homo sapiens	Q9Y282	Y2H Prey Pooling	32296183
Intra	ASGR1	P07306	ERGIC3	Homo sapiens	Q9Y282	Y2H Array	32296183
Intra	ASGR1	P07306	KIR2DL3	Homo sapiens	P43628	Y2H Prey Pooling	32296183
Intra	ASGR1	P07306	KIR2DL3	Homo sapiens	P43628	Validated Y2H	32296183
Intra	ASGR1	P07306	KIR2DL3	Homo sapiens	P43628	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant ASGR1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7610	ASGR1/ASGPR1 Protein, Human (HEK293, His)	P07306-1 (Q62-L291)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P78931	ASGR1/ASGPR1 Protein, Human (Biotinylated, HEK293, His-Avi)	P07306-1 (Q62-L291)	≥ 95%, as determined by reducing SDS-PAGE.

ASGR1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81553	ASGPR1 Antibody (YA1298)	WB, IHC-P, ICC/IF, IP, FC, IF-Tissue	Human, Rat

Related Diseases

Diseases	Alias
Hepatitis	Chronic Hepatitis Chronic Persistent Hepatitis Acute Hepatitis Hepatitis, Chronic Acute And Subacute Liver Necrosis Acute/Subac. Necrosis Of Liver Animal Hepatitis Hepatitis Chronic Hepatitis A Hepatitis, Animal Hepatitis Due To Toxoplasmosis Hepatitis In Toxoplasmosis Toxoplasmal Hepatitis Chronic Hepatitis, Unspecified Chronic Active Hepatitis Nec Other Specified Chronic Hepatitis Chronic Persistent Hepatitis Nec Chronic Lobular Hepatitis Nec
Hepatitis B	Chronic Hepatitis B Hepatitis B Infection Serum Hepatitis HBV Hepatitis B Chronic Hbv, Susceptibility To Hepatitis B, Chronic Chronic Hepatitis B Without Delta Agent Chronic Hbv - [Hepatitis B Virus] Infection Hepatitis B Nos Chronic Type B Viral Hepatitis Hep B Nos
Hepatitis E
Autoimmune Hepatitis	Aih Hepatitis, Autoimmune Autoimmune Chronic Active Hepatitis Autoimmune Hepatitis With Centrilobular Necrosis Autoimmune Chronic Hepatitis Hepatitis Autoimmune
Acute Gonococcal Cervicitis	Gonococcal Cervicitis Acute Gonorrhea Of Cervix
Amelogenesis Imperfecta, Type Ib	AI1B Aih2 Amelogenesis Imperfecta Type 1b Amelogenesis Imperfecta Type Ib Hereditary Localized Enamel Hypoplasia Amelogenesis Imperfecta - Hypoplastic Autosomal Dominant - Local Amelogenesis Imperfecta, Hypoplastic Local, Autosomal Dominant Enamel Hypoplasia, Hereditary Localized Autosomal Dominant Hypoplastic Local Amelogenesis Imperfecta Amelogenesis Imperfecta 1b Amelogenesis Imperfecta Hypoplastic 2 Amelogenesis Imperfecta Hypoplastic Local Autosomal Dominant
Amelogenesis Imperfecta, Type Ie	Aih1 Amelogenesis Imperfecta Type 1e AI1E Amelogenesis Imperfecta, Hypoplastic/Hypomaturation, X-Linked 1 Amelogenesis Imperfecta, Hypomaturation Type, With Snow-Capped Teeth Enamel Hypoplasia, X-Linked Amelogenesis Imperfecta Type Ie Amelogenesis Imperfecta Hypoplastic/Hypomaturation X-Linked 1 Enamel Hypoplasia X-Linked Amelogenesis Imperfecta, X-Linked 1 Amelogenesis Imperfecta, Type 1e Amelogenesis Imperfecta Hypomaturationtype With Snow-Capped Teeth X-Linked Amelogenesis Imperfecta 1 X-Linked Amelogenesis Imperfecta Hypoplastic/Hypomaturation 1 X-Linked Enamel Hypoplasia Amelogenesis Imperfecta X-Linked 1 Amelogenesis Imperfecta 1e Amelogenesis Imperfecta, Hypoplastic/Hypomaturation Type 1e Amelogenesis Imperfecta Hypomaturation Type With Snow-Capped Teeth Xai X-Linked Amelogenesis Imperfecta Amelogenesis Imperfecta, Hypoplastic/Hypomaturation, X-Linked 2
Acute Cervicitis
Amyloidosis, Hereditary, Transthyretin-Related	Transthyretin Amyloidosis Familial Amyloid Polyneuropathy Ttr Amyloid Neuropathy Transthyretin Amyloid Neuropathy Transthyretin Amyloid Polyneuropathy Fap Familial Transthyretin Amyloidosis Amyloidosis Transthyretin Related Type I Familial Amyloid Polyneuropathy Familial Amyloid Polyneuropathy Type I Attrv122i Amyloidosis Hereditary Amyloidosis, Transthyretin-Related Amyloid Polyneuropathy, Familial Attr Amyloidosis Attrm Amyloidosis Corino De Andrade'S Disease Paramyloidosis Transthyretin-Related Hereditary Amyloidosis Ttr Amyloidosis Hereditary Attr Amyloidosis Portuguese Polyneuritic Amyloidosis Portuguese Type Familial Amyloid Neuropathy Swiss Type Amyloid Polyneuropathy Type Ii Familial Amyloid Polyneuropathy Attrv30m Amyloidosis Attrv30m-Related Amyloidosis Familial Amyloid Polyneuropathy, Portuguese-Swedish-Japanese Type Attr Cardiomyopathy Attrv122i-Related Amyloidosis Ttr-Related Amyloid Cardiomyopathy Ttr-Related Cardiac Amyloidosis Transthyretin Amyloid Cardiopathy Transthyretin-Related Familial Amyloid Cardiomyopathy Amyloidosis, Transthyretin-Related AMYL-TTR Amyloidosis I Amyloidosis Ohio Type Amyloidosis Type 7 Amyloidosis Vii Amyloid Polyneuropathy Attr Familial Amyloid Polyneuropathy Type Ii Hereditary Amyloidosis Transthyretin-Related Leptomeningeal Amyloidosis Meningocerebrovascular Amyloidosis Oculoleptomeningeal Amyloidosis Familial Amyloid Polyneuropathies Amyloidosis, Leptomeningeal Senile Cardiac Amyloidosis Amyloid Neuropathies, Familial Danish Type Familial Amyloid Cardiomyopathy Familial Amyloid Neuropathy, Portuguese Type Amyloid Polyneuropathy, Swiss Type Hereditary Oculoleptomeningeal Amyloid Angiopathy Amyloid Neuropathies
Crigler-Najjar Syndrome, Type I	Crigler-Najjar Syndrome Crigler-Najjar Syndrome Type 1 Bilirubin Udp Glucuronyl Transferase Deficiency Crigler Najjar Syndrome Crigler Najjar Syndrome, Type 1 Bilirubin Uridinediphosphate Glucuronosyltransferase Deficiency Bilirubin-Ugt Deficiency Hyperbilirubinemia, Crigler-Najjar Type I Hblrcn1 Familial Nonhemolytic Unconjugated Hyperbilirubinemia Hereditary Unconjugated Hyperbilirubinemia Bilirubin Uridinediphosphate Glucuronosyltransferase Deficiency Type 1 Bilirubin-Ugt Deficiency Type 1 Crigler-Najjar Syndrome 1 CN1 Cn-I Crigler-Najjar Syndrome Type I Hereditary Unconjugated Hyperbilirubinaemia Ugt Deficiency Bilirubin Glucuronosyltransferase Deficiency Crigler-Najjar Disease Or Syndrome Deficiency Of Glucuronosyltransferase Glucuronyl Transferase Deficiency Glucuronyltransferase Deficiency Udp Glucuronyl Transferase Deficiency Cns - [Crigler-Najjar Syndrome] Congenital Familial Nonhemolytic Jaundice

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01085	ASGR1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS16994	Asgr1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23437	Asgr1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Inhibitory Antibodies (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P991222	AMG-529	Activator	98.10%	Unkown
HY-P991872	Anti-ASGR1 Antibody		/	Unkown
HY-P992458	SBT8230 Antibody		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	ASGR1	RGD	RGD:2160
Mus musculus	ASGR1	MGD	MGI:88081
Bos taurus	ASGR1	VGNC	VGNC:26209
Macaca mulatta	ASGR1	VGNC	VGNC:99120
Others	ASGR1	NCBI