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BLCAP - BLCAP apoptosis inducing factor Gene

Also Known as BC10

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 10904

About BLCAP

Cytogenetic location: 20q11.23 Genomic coordinates (GRCh38): 20:37,517,417-37,527,876 (from NCBI)

This gene has 14 transcripts (splice variants) and 197 orthologues. Ubiquitous expression in brain (RPKM 29.8), placenta (RPKM 23.5) and 24 other tissues.

Summary

This gene encodes a protein that reduces cell growth by stimulating Apoptosis. Alternative splicing and the use of alternative promoters result in multiple transcript variants encoding the same protein. This gene is imprinted in brain where different transcript variants are expressed from each parental allele. Transcript variants initiating from the upstream promoter are expressed preferentially from the maternal allele, while transcript variants initiating downstream of the interspersed NNAT gene (GeneID:4826) are expressed from the paternal allele. Transcripts at this locus may also undergo A to I editing, resulting in amino acid changes at three positions in the N-terminus of the protein. [provided by RefSeq, Nov 2015]

BLCAP Products (7)

mRNA	Protein	Name
NM_001167820.2	NP_001161292.1	bladder cancer-associated protein
NM_001167821.2	NP_001161293.1	bladder cancer-associated protein
NM_001167822.3	NP_001161294.1	bladder cancer-associated protein
NM_001167823.2	NP_001161295.1	bladder cancer-associated protein
NM_001317074.2	NP_001304003.1	bladder cancer-associated protein
NM_001317075.2	NP_001304004.1	bladder cancer-associated protein
NM_006698.4	NP_006689.1	bladder cancer-associated protein

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	21217774	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in apoptotic nuclear changes	IDA IDA: Inferred from direct assay	17031575	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

BLCAP Protein Structure

BC10

0
87 a.a.

Protein Preferred Names	Protein Names
bladder cancer-associated protein	bladder cancer associated protein

BLCAP Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	BLCAP	P62952	TMEM237	Homo sapiens	Q96Q45-2	Y2H Array	32296183
Intra	BLCAP	P62952	TMEM237	Homo sapiens	Q96Q45-2	Y2H Prey Pooling	32296183
Intra	BLCAP	P62952	TMEM237	Homo sapiens	Q96Q45-2	Validated Y2H	32296183
Intra	BLCAP	P62952	CLDND2	Homo sapiens	Q8NHS1	Validated Y2H	32296183
Intra	BLCAP	P62952	GIMAP1	Homo sapiens	Q8WWP7	Validated Y2H	32296183
Intra	BLCAP	P62952	FAM241B	Homo sapiens	Q96D05-2	Validated Y2H	32296183
Intra	BLCAP	P62952	LEMD1	Homo sapiens	Q68G75	Validated Y2H	32296183
Intra	BLCAP	P62952	SSMEM1	Homo sapiens	Q8WWF3	Y2H Array	32296183
Intra	BLCAP	P62952	SSMEM1	Homo sapiens	Q8WWF3	Y2H Prey Pooling	32296183
Intra	BLCAP	P62952	SSMEM1	Homo sapiens	Q8WWF3	Validated Y2H	32296183
Intra	BLCAP	P62952	SKAP1	Homo sapiens	Q86WV1	Validated Y2H	25416956
Intra	BLCAP	P62952	CYSRT1	Homo sapiens	A8MQ03	Y2H Array	32296183
Intra	BLCAP	P62952	CYSRT1	Homo sapiens	A8MQ03	Y2H Prey Pooling	32296183
Intra	BLCAP	P62952	MFSD5	Homo sapiens	Q6N075	Validated Y2H	32296183
Intra	BLCAP	P62952	MFSD5	Homo sapiens	Q6N075	Y2H Array	32296183
Intra	BLCAP	P62952	MFSD5	Homo sapiens	Q6N075	Y2H Prey Pooling	32296183
Intra	BLCAP	P62952	HOXA1	Homo sapiens	P49639	Y2H Prey Pooling	32296183
Intra	BLCAP	P62952	HOXA1	Homo sapiens	P49639	Y2H Array	32296183
Intra	BLCAP	P62952	GJA5	Homo sapiens	P36382	Y2H Array	32296183
Intra	BLCAP	P62952	GJA5	Homo sapiens	P36382	Y2H Prey Pooling	32296183
Intra	BLCAP	P62952	ESR1	Homo sapiens	P03372	Phage Display	21217774
Intra	BLCAP	P62952	TMEM14B	Homo sapiens	Q9NUH8	Y2H Prey Pooling	32296183
Intra	BLCAP	P62952	TMEM14B	Homo sapiens	Q9NUH8	Validated Y2H	32296183
Intra	BLCAP	P62952	TMEM14B	Homo sapiens	Q9NUH8	Y2H Array	32296183
Intra	BLCAP	P62952	NOTCH2NLA	Homo sapiens	Q7Z3S9	Y2H Array	31515488
Intra	BLCAP	P62952	NOTCH2NLA	Homo sapiens	Q7Z3S9	Y2H Array	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Bladder Cancer	Urinary Bladder Cancer Bladder Carcinoma Urinary Bladder Carcinoma Bladder Neoplasm Bladder Tumor Cancer, Bladder Malignant Neoplasm Of Urinary Bladder Carcinoma Of Bladder Bladder Cancer, Somatic Tumor Of The Bladder Carcinoma Of Urinary Bladder Bladder Carcinoma Urinary Cancer Of The Urinary Bladder Cancer, Urinary Bladder Malignant Bladder Neoplasm Malignant Bladder Tumor Neoplasm Of The Bladder Neoplasm Of The Urinary Bladder Tumor Of The Urinary Bladder Urinary Bladder Neoplasm BLC Urothelial Carcinoma Of The Bladder Bladder Tumors Urinary Bladder Neoplasms Bladder Cancer Nos Vesical Cancer Nos Malignant Neoplasm Of Bladder, Part Unspecified Malignant Tumour Of Urinary Bladder Primary Malignant Neoplasm Of Bladder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval
Pre-clinical Phase

Approval

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-N0510	Aristolochic acid A	Inhibitor	99.91%	Unkown

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-N0510A	Aristolochic acid A sodium	Inhibitor	99.93%	Unkown
HY-RS01517	BLCAP Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	BLCAP	VGNC	VGNC:54698
Felis catus	BLCAP	VGNC	VGNC:60120
Mus musculus	BLCAP	MGD	MGI:1858907
Macaca mulatta	BLCAP	VGNC	VGNC:84546
Rattus norvegicus	BLCAP	RGD	RGD:621666
Bos taurus	BLCAP	VGNC	VGNC:54701
Others	BLCAP	NCBI