CD200 - CD200 molecule Gene

Also Known as MRC; MOX1; MOX2; OX-2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 4345

About CD200

Cytogenetic location: 3q13.2 Genomic coordinates (GRCh38): 3:112,332,573-112,362,812 (from NCBI)

This gene has 8 transcripts (splice variants), 512 orthologues and 14 paralogues. Broad expression in brain (RPKM 5.4), placenta (RPKM 3.5) and 22 other tissues.

Summary

This gene encodes a type I membrane glycoprotein containing two extracellular immunoglobulin domains, a transmembrane and a cytoplasmic domain. This gene is expressed by various cell types, including B cells, a subset of T cells, thymocytes, endothelial cells, and neurons. The encoded protein plays an important role in immunosuppression and regulation of anti-tumor activity. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016]

CD200 Products (10)

mRNA Protein Name
NM_001004196.4 NP_001004196.2 OX-2 membrane glycoprotein isoform b
NM_001318826.2 NP_001305755.1 OX-2 membrane glycoprotein isoform c
NM_001318828.2 NP_001305757.1 OX-2 membrane glycoprotein isoform d
NM_001318830.2 NP_001305759.1 OX-2 membrane glycoprotein isoform c
NM_001365851.2 NP_001352780.1 OX-2 membrane glycoprotein isoform e precursor
NM_001365852.1 NP_001352781.1 OX-2 membrane glycoprotein isoform f precursor
NM_001365853.1 NP_001352782.1 OX-2 membrane glycoprotein isoform f precursor
NM_001365854.1 NP_001352783.1 OX-2 membrane glycoprotein isoform f precursor
NM_001365855.1 NP_001352784.1 OX-2 membrane glycoprotein isoform c
NM_005944.7 NP_005935.4 OX-2 membrane glycoprotein isoform a precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
21982860 GOA
Biological Process GO Annotation Evidence References Source
involved in heterotypic cell-cell adhesion IGI
IGI: Inferred from genetic interaction
11260322 GOA
involved in negative regulation of NF-kappaB transcription factor activity IDA
IDA: Inferred from direct assay
26670206 GOA
involved in negative regulation of matrix metallopeptidase secretion IDA
IDA: Inferred from direct assay
29101312 GOA
involved in positive regulation of CREB transcription factor activity IDA
IDA: Inferred from direct assay
26670206 GOA
involved in positive regulation of arginase activity IGI
IGI: Inferred from genetic interaction
26670206 GOA
involved in positive regulation of protein-glutamine gamma-glutamyltransferase activity IGI
IGI: Inferred from genetic interaction
26670206 GOA
involved in positive regulation of transforming growth factor beta production IGI
IGI: Inferred from genetic interaction
26670206 GOA
Cellular Component GO Annotation Evidence References Source
located in axon IDA
IDA: Inferred from direct assay
19151626 GOA
located in cell body IDA
IDA: Inferred from direct assay
19151626 GOA
located in cell surface IDA
IDA: Inferred from direct assay
11260322 GOA
located in neuronal cell body IDA
IDA: Inferred from direct assay
19151626 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CD200 Protein Structure

ig

ig: Immunoglobulin domain (72 - 146)

ig

ig: Immunoglobulin domain (179 - 241)

  • 0
  • 100
  • 200
  • 294 a.a.
Protein Preferred Names Protein Names

OX-2 membrane glycoprotein

  • CD200 antigen

CD200 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
CD200 P41217 CD200R1 Homo sapiens Q8TD46
Protein Array
21982860
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CD200 Proteins

Cat. No. Product Name Accession Purity
HY-P70476 CD200 Protein, Human (HEK293, His) P41217-1 (Q31-G232) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P72887 CD200 Protein, Human (HEK293, Fc) P41217-1 (Q31-G232) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P75432 CD200 Protein, Human (HEK293, Fc-Avi) P41217-1/NP_005935.4 (Q31-G232) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P78915 CD200 Protein, Human (Biotinylated, HEK293, Fc-Avi) P41217-1 (Q31-G232) ≥ 95%, as determined by reducing SDS-PAGE.

CD200 Antibodies

Cat. No. Product Name Application Reactivity
HY-P81630 CD200 Antibody (YA1375) WB, IHC-P, FC, ELISA, IF-Tissue Human
HY-P84304 CD200 Antibody (YA4001) ICC/IF, FC, ELISA Human
HY-P84304A CD200 Antibody (YA4001)(PBS only) ICC/IF, FC, ELISA Human

Related Diseases

Diseases Alias
Inflamed Seborrheic Keratosis
Hairy Cell Leukemia

  • Hcl-V

  • Hairy Cell Leukemia Variant

  • Hairy Cell Leukaemia Variant

  • Hcl

  • Leukemic Reticuloendotheliosis

  • Leukemic Reticuloendotheliosis Variant

  • Prolymphocytic Variant Of Hcl

  • Prolymphocytic Variant Of Hairy Cell Leukemia

  • Leukemia Hairy Cell

  • Leukemia, Hairy Cell

  • Leukaemic Reticuloendotheliosis

  • Lre - [Leukemic Reticuloendotheliosis]

  • Hairy-Cell Leukaemia, Nos

  • Hcl - [Hairy Cell Leukaemia]

  • Hairy-Cell Leukaemia Without Mention Of Remission
B-Cell Prolymphocytic Leukemia

  • B Cell Prolymphocytic Leukemia

  • Prolymphocytic Leukemia, B-Cell Type

  • B-Pll

  • Doid:0081041

  • Leukemia, Prolymphocytic, B-Cell

  • Pll- [Prolymphocytic Leukaemia]

  • Prolymphocytic Leukaemia

  • Prolymphocytic Leukaemia Of B-Cell Type Without Mention Of Remission
Spiradenoma

  • Eccrine Spiradenoma

  • Benign Eccrine Spiradenoma

  • Eccrine Spiradenoma Of Skin

  • Es

  • Eccrine Spiradenoma, Benign
Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma

  • Cll/Sll

  • B-Cell Lymphocytic Leukemia/Small Lymphocytic Lymphoma

  • Icdo:9823/3

  • Chronic Lymphocytic Leukaemia Of B-Cell Type Without Mention Of Remission

  • Small Cell B-Cell Lymphoma
Androgenic Alopecia

  • Androgenetic Alopecia

  • Alopecia Androgenetica, Male Pattern Baldness
Methemoglobinemia And Ambiguous Genitalia

  • METAG

  • Methemoglobinemia Type Iv

  • Isolated 17,20-Lyase Deficiency, Pure

  • Methemoglobinemia Due To Deficiency Of Cytochrome B5

  • Methemoglobinemia Type 4

  • Methemoglobinemia Type Iv, Formerly

  • Methemoglobinemia Due To Deficiency Of Cytochrome B5, Formerly

  • Pure Isolated 17,20-Lyase Deficiency

  • Methemoglobinemia, Type Iv
Rocky Mountain Spotted Fever

  • Brazillian Spotted

  • Choix

  • Exanthematic Typhus Of Sao Paulo

  • Fiebre Maculosa

  • Fiebre Manchada

  • Sao Paulo Typhus

  • So Paulo Fever

  • Tick Typhus

  • Tobia Fever

  • Rmsf

  • Typhus, Tick
Atrial Septal Defect 8

  • ASD8

  • Atrial Heart Septal Defect 8

  • Septal Defect, Atrial, Type 8
Flying Phobia

  • Aerophobia
Combined Oxidative Phosphorylation Deficiency 33

  • COXPD33
Mantle Cell Lymphoma

  • Lymphoma, Mantle Cell

  • Lcm

  • Mcl

  • Mantle Zone Lymphoma

  • Lymphoma Mantle-Cell

  • Lymphoma, Mantle-Cell

  • Malignant Lymphoma, Lymphocytic, Intermediate Differentiation, Diffuse

  • Malignant Lymphoma - Lymphocytic, Intermediate Differentiation

  • Diffuse Small Cleaved-Cell Lymphoma

  • Diffuse Small Cleaved Cell Malignant Lymphoma

  • Small Cleaved Cell Non-Hodgkin Lymphoma

  • Diffuse Non-Hodgkin Small Cleaved Cell Lymphoma

  • Malignant Lymphomatous Polyposis

  • Malignant Small Cell, Noncleaved, Diffuse Lymphoma

  • Malignant Undifferentiated Cell, Non-Burkitt Lymphoma

  • Cleaved Cell Lymphoma

  • Small Cell Mantle Cell Lymphoma

  • Small Cleaved Cell Malignant Lymphoma
Aniridia 1

  • Aniridia

  • Congenital Aniridia

  • AN1

  • An

  • Cataract With Late-Onset Corneal Dystrophy

  • Aplasia Of Iris

  • Absent Iris

  • Irideremia

  • Aniridia Ii, Formerly

  • An2, Formerly

  • An2

  • Aniridia Type Ii

  • Aniridia, Type 1

  • An-1

  • Absence Of Iris

  • Agenesis Of Iris

  • Congenital Absence Of Iris

  • Hereditary Aniridia

  • Sporadic Aniridia
Leukemia, Chronic Lymphocytic

  • Chronic Lymphocytic Leukemia

  • B-Cell Chronic Lymphocytic Leukemia

  • CLL

  • B-Cell Chronic Lymphoid Leukemia

  • Chronic Lymphatic Leukemia

  • Chronic Lymphocytic Leukaemia

  • Lymphoplasmacytic Leukemia

  • Small Lymphocytic Lymphoma

  • Leukemia, Chronic Lymphatic

  • B-Cell Chronic Lymphocytic Leukaemia

  • Chronic Lymphatic Leukaemia

  • Lymphoplasmacytic Leukaemia

  • B Cell Chronic Lymphocytic Leukemia

  • Chronic B-Cell Lymphocytic Leukemia

  • Leukemia, Lymphocytic, Chronic

  • B-Cll

  • Chronic Lymphoid Leukemia

  • Leukemia Lymphocytic Chronic

  • Lymphoma Small Lymphocytic

  • Leukemia, Lymphocytic, Chronic, B-Cell
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (9)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS18434 Cd200r1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS02205 CD200 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS02206 CD200R1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS02207 CD200R1L Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS16811 Cd200 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21271 Cd200r1l Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23251 Cd200 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24915 Cd200r1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27789 Cd200r1l Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P992113 Evabosmig Inhibitor / Unkown
HY-P990479 Anti-OX2R/CD200R1 Antibody Inhibitor / Unkown
HY-P991452 Anti-CD200R1/OX2R Antibody (I-4P) Inhibitor / Unkown
HY-P992162 23ME-00610 / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris CD200 VGNC VGNC:38938
Felis catus CD200 VGNC VGNC:102623
Rattus norvegicus CD200 RGD RGD:3104
Bos taurus CD200 VGNC VGNC:27010
Macaca mulatta CD200 VGNC VGNC:70931
Mus musculus CD200 MGD MGI:1196990
Others CD200 NCBI