2. Gene
  3. CD200 - CD200 molecule Gene

CD200 - CD200 molecule Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as MRC; MOX1; MOX2; OX-2

Gene ID: 4345 | Gene type: protein coding

About CD200

Cytogenetic location: 3q13.2 Genomic coordinates (GRCh38): 3:112,332,573-112,362,812 (from NCBI)

This gene has 8 transcripts (splice variants), 512 orthologues and 14 paralogues. Broad expression in brain (RPKM 5.4), placenta (RPKM 3.5) and 22 other tissues.

Summary

This gene encodes a type I membrane glycoprotein containing two extracellular immunoglobulin domains, a transmembrane and a cytoplasmic domain. This gene is expressed by various cell types, including B cells, a subset of T cells, thymocytes, endothelial cells, and neurons. The encoded protein plays an important role in immunosuppression and regulation of anti-tumor activity. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016]

CD200 Products(10)

mRNA Protein Name
NM_001004196.4 NP_001004196.2 OX-2 membrane glycoprotein isoform b
NM_001318826.2 NP_001305755.1 OX-2 membrane glycoprotein isoform c
NM_001318828.2 NP_001305757.1 OX-2 membrane glycoprotein isoform d
NM_001318830.2 NP_001305759.1 OX-2 membrane glycoprotein isoform c
NM_001365851.2 NP_001352780.1 OX-2 membrane glycoprotein isoform e precursor
NM_001365852.1 NP_001352781.1 OX-2 membrane glycoprotein isoform f precursor
NM_001365853.1 NP_001352782.1 OX-2 membrane glycoprotein isoform f precursor
NM_001365854.1 NP_001352783.1 OX-2 membrane glycoprotein isoform f precursor
NM_001365855.1 NP_001352784.1 OX-2 membrane glycoprotein isoform c
NM_005944.7 NP_005935.4 OX-2 membrane glycoprotein isoform a precursor

CD200 Protein Structure

ig

ig: Immunoglobulin domain (72 - 146)

ig

ig: Immunoglobulin domain (179 - 241)

  • 0
  • 100
  • 200
  • 294 a.a.
Protein Preferred Names Protein Names

OX-2 membrane glycoprotein

CD200 antigen

Recombinant CD200 Proteins

Cat. No. Product Name Accession Purity
HY-P70476 CD200 Protein, Human (HEK293, His) P41217 (Q31-G232) ≥95%
HY-P72887 CD200 Protein, Human (HEK293, Fc) P41217 (Q31-G232) ≥95%
HY-P72888 CD200 Protein, Human (HEK293, His-Fc) P41217 (M1-G232) ≥95%
HY-P75432 CD200 Protein, Human (HEK293, Fc-Avi) P41217 (Q31-G232) ≥95%
HY-P78915 CD200 Protein, Human (Biotinylated, HEK293, Fc-Avi) P41217 (Q31-G232) ≥95%
HY-P78916 CD200 Protein, Human (Biotinylated, L234A, L235A, P329G, HEK293, Fc-Avi) P41217 (Q31-G232) ≥95%

Related Diseases

Diseases Alias
Inflamed Seborrheic Keratosis
Hairy Cell Leukemia

Hcl-V

Hairy Cell Leukemia Variant

Hairy Cell Leukaemia Variant

Hcl

Leukemic Reticuloendotheliosis

Leukemic Reticuloendotheliosis Variant

Prolymphocytic Variant Of Hcl

Prolymphocytic Variant Of Hairy Cell Leukemia

Leukemia Hairy Cell

Leukemia, Hairy Cell

Leukaemic Reticuloendotheliosis

Lre - [Leukemic Reticuloendotheliosis]

Hairy-Cell Leukaemia, Nos

Hcl - [Hairy Cell Leukaemia]

Hairy-Cell Leukaemia Without Mention Of Remission
B-Cell Prolymphocytic Leukemia

B Cell Prolymphocytic Leukemia

Prolymphocytic Leukemia, B-Cell Type

B-Pll

Doid:0081041

Leukemia, Prolymphocytic, B-Cell

Pll- [Prolymphocytic Leukaemia]

Prolymphocytic Leukaemia

Prolymphocytic Leukaemia Of B-Cell Type Without Mention Of Remission
Spiradenoma

Eccrine Spiradenoma

Benign Eccrine Spiradenoma

Eccrine Spiradenoma Of Skin

Es

Eccrine Spiradenoma, Benign
Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma

Cll/Sll

B-Cell Lymphocytic Leukemia/Small Lymphocytic Lymphoma

Icdo:9823/3

Chronic Lymphocytic Leukaemia Of B-Cell Type Without Mention Of Remission

Small Cell B-Cell Lymphoma
Androgenic Alopecia

Androgenetic Alopecia

Alopecia Androgenetica, Male Pattern Baldness
Methemoglobinemia And Ambiguous Genitalia

METAG

Methemoglobinemia Type Iv

Isolated 17,20-Lyase Deficiency, Pure

Methemoglobinemia Due To Deficiency Of Cytochrome B5

Methemoglobinemia Type 4

Methemoglobinemia Type Iv, Formerly

Methemoglobinemia Due To Deficiency Of Cytochrome B5, Formerly

Pure Isolated 17,20-Lyase Deficiency

Methemoglobinemia, Type Iv
Rocky Mountain Spotted Fever

Brazillian Spotted

Choix

Exanthematic Typhus Of Sao Paulo

Fiebre Maculosa

Fiebre Manchada

Sao Paulo Typhus

So Paulo Fever

Tick Typhus

Tobia Fever

Rmsf

Typhus, Tick
Atrial Septal Defect 8

ASD8

Atrial Heart Septal Defect 8

Septal Defect, Atrial, Type 8
Flying Phobia

Aerophobia
Combined Oxidative Phosphorylation Deficiency 33

COXPD33
Mantle Cell Lymphoma

Lymphoma, Mantle Cell

Lcm

Mcl

Mantle Zone Lymphoma

Lymphoma Mantle-Cell

Lymphoma, Mantle-Cell

Malignant Lymphoma, Lymphocytic, Intermediate Differentiation, Diffuse

Malignant Lymphoma - Lymphocytic, Intermediate Differentiation

Diffuse Small Cleaved-Cell Lymphoma

Diffuse Small Cleaved Cell Malignant Lymphoma

Small Cleaved Cell Non-Hodgkin Lymphoma

Diffuse Non-Hodgkin Small Cleaved Cell Lymphoma

Malignant Lymphomatous Polyposis

Malignant Small Cell, Noncleaved, Diffuse Lymphoma

Malignant Undifferentiated Cell, Non-Burkitt Lymphoma

Cleaved Cell Lymphoma

Small Cell Mantle Cell Lymphoma

Small Cleaved Cell Malignant Lymphoma
Aniridia 1

Aniridia

Congenital Aniridia

AN1

An

Cataract With Late-Onset Corneal Dystrophy

Aplasia Of Iris

Absent Iris

Irideremia

Aniridia Ii, Formerly

An2, Formerly

An2

Aniridia Type Ii

Aniridia, Type 1

An-1

Absence Of Iris

Agenesis Of Iris

Congenital Absence Of Iris

Hereditary Aniridia

Sporadic Aniridia
Leukemia, Chronic Lymphocytic

Chronic Lymphocytic Leukemia

B-Cell Chronic Lymphocytic Leukemia

CLL

B-Cell Chronic Lymphoid Leukemia

Chronic Lymphatic Leukemia

Chronic Lymphocytic Leukaemia

Lymphoplasmacytic Leukemia

Small Lymphocytic Lymphoma

Leukemia, Chronic Lymphatic

B-Cell Chronic Lymphocytic Leukaemia

Chronic Lymphatic Leukaemia

Lymphoplasmacytic Leukaemia

B Cell Chronic Lymphocytic Leukemia

Chronic B-Cell Lymphocytic Leukemia

Leukemia, Lymphocytic, Chronic

B-Cll

Chronic Lymphoid Leukemia

Leukemia Lymphocytic Chronic

Lymphoma Small Lymphocytic

Leukemia, Lymphocytic, Chronic, B-Cell
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS02205 CD200 Human Pre-designed siRNA Set A / Unkown
HY-RS02206 CD200R1 Human Pre-designed siRNA Set A / Unkown
HY-RS02207 CD200R1L Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris CD200 VGNC VGNC:38938
Felis catus CD200 VGNC VGNC:102623
Rattus norvegicus CD200 RGD RGD:3104
Bos taurus CD200 VGNC VGNC:27010
Macaca mulatta CD200 VGNC VGNC:70931
Mus musculus CD200 MGD MGI:1196990
Macaca fascicularis CD200 NCBI
Others CD200 NCBI