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GADD45B - growth arrest and DNA damage inducible beta Gene

Also Known as MYD118; GADD45BETA

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 4616

About GADD45B

Cytogenetic location: 19p13.3 Genomic coordinates (GRCh38): 19:2,476,127-2,478,257 (from NCBI)

This gene has 7 transcripts (splice variants), 257 orthologues and 2 paralogues. Broad expression in liver (RPKM 112.2), bone marrow (RPKM 99.7) and 23 other tissues.

Summary

This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The genes in this group respond to environmental stresses by mediating activation of the p38/JNK pathway. This activation is mediated via their proteins binding and activating MTK1/MEKK4 kinase, which is an upstream activator of both p38 and JNK MAPKs. The function of these genes or their protein products is involved in the regulation of growth and Apoptosis. These genes are regulated by different mechanisms, but they are often coordinately expressed and can function cooperatively in inhibiting cell growth. [provided by RefSeq, Jul 2008]

GADD45B Products (1)

mRNA	Protein	Name
NM_015675.4	NP_056490.2	growth arrest and DNA damage-inducible protein GADD45 beta

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	12052864	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in positive regulation of JNK cascade	IDA IDA: Inferred from direct assay	9827804	GOA
involved in positive regulation of apoptotic process	IDA IDA: Inferred from direct assay	9827804	GOA
involved in positive regulation of p38MAPK cascade	IDA IDA: Inferred from direct assay	9827804	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	9827804	GOA
located in nucleus	IDA IDA: Inferred from direct assay	9827804	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GADD45B Protein Structure

Ribosomal_L7Ae

0
100
160 a.a.

Protein Preferred Names	Protein Names
growth arrest and DNA damage-inducible protein GADD45 beta	myeloid differentiation primary response protein MyD118

GADD45B Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	GADD45B	O75293	CNOT9	Homo sapiens	Q92600-3	Validated Y2H	32296183
Intra	GADD45B	O75293	MAP3K4	Homo sapiens	Q9Y6R4	Anti Bait CoIP	16256071
Intra	GADD45B	O75293	MAP3K4	Homo sapiens	Q9Y6R4	DHFR Reconstruction	12052864
Intra	GADD45B	O75293	MAP3K4	Homo sapiens	Q9Y6R4	Anti Tag CoIP	33961781
Intra	GADD45B	O75293	MAP2K7	Homo sapiens	O14733	Solid Phase Assay	25314077
Intra	GADD45B	O75293	MAP2K7	Homo sapiens	O14733	Anti Tag CoIP	25314077
Intra	GADD45B	O75293	EFHC1	Homo sapiens	Q5JVL4	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant GADD45B Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70212	GADD45B Protein, Human (His)	O75293 (M1-R160)	≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Susceptibility To Lung Cancer, Protection Against Adenocarcinoma Of Lung, Somatic Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma
Metaphyseal Chondrodysplasia, Schmid Type	MCDS Schmid Metaphyseal Chondrodysplasia Metaphyseal Chondrodysplasia Schmid Type Spondylometaphyseal Dysplasia, Japanese Type Japanese Type Spondylometaphyseal Dysplasia Schmid Type Metaphyseal Dysplasia Metaphyseal Chondrodysplasia Type Schmid Schmid Type Metaphyseal Chondrodysplasia SMCD Chondrodysplasia, Metaphyseal, Schmid Type Corneal Dystrophy, Subepithelial Mucinous

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05230	GADD45B Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18014	Gadd45b Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24487	Gadd45b Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	GADD45B	VGNC	VGNC:72864
Canis familiaris	GADD45B	VGNC	VGNC:41070
Bos taurus	GADD45B	VGNC	VGNC:29207
Rattus norvegicus	GADD45B	RGD	RGD:1309080
Felis catus	GADD45B	VGNC	VGNC:62432
Mus musculus	GADD45B	MGD	MGI:107776
Others	GADD45B	NCBI