TYK2 - tyrosine kinase 2 Gene

Canis lupus familiaris (sub-species: familiaris)

Gene ID: 476714 | Gene type: protein coding

About TYK2

Primary_assembly 20: 51,269,646-51,291,659 forward strand.ROS_Cfam_1.0:CM025119.1

This gene has 3 transcripts (splice variants), 197 orthologues and 32 paralogues.

TYK2 Products(10)

mRNA	Protein	Name
XM_038428656.1	XP_038284584.1	non-receptor tyrosine-protein kinase TYK2 isoform X1
XM_038428663.1	XP_038284591.1	non-receptor tyrosine-protein kinase TYK2 isoform X2
XM_038428660.1	XP_038284588.1	non-receptor tyrosine-protein kinase TYK2 isoform X1
XM_038428657.1	XP_038284585.1	non-receptor tyrosine-protein kinase TYK2 isoform X1
XM_038428654.1	XP_038284582.1	non-receptor tyrosine-protein kinase TYK2 isoform X1
XM_038428655.1	XP_038284583.1	non-receptor tyrosine-protein kinase TYK2 isoform X1
XM_038428661.1	XP_038284589.1	non-receptor tyrosine-protein kinase TYK2 isoform X1
XM_038428658.1	XP_038284586.1	non-receptor tyrosine-protein kinase TYK2 isoform X1
XM_038428659.1	XP_038284587.1	non-receptor tyrosine-protein kinase TYK2 isoform X1
XM_038428662.1	XP_038284590.1	non-receptor tyrosine-protein kinase TYK2 isoform X1

TYK2 Protein Structure

FERM_F1

FERM_F2

Jak1_Phl

SH2

PKc_like

PTKc_Tyk2_rpt2

0
200
400
600
800
1000
1180 a.a.

Protein Preferred Names

Protein Names

non-receptor tyrosine-protein kinase TYK2

Related Agents

Approval

Bioactive Molecules (19)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-50856	Ruxolitinib	Inhibitor	99.99%	Yes
HY-19569	Upadacitinib	Inhibitor	99.98%	Yes
HY-15315	Baricitinib	Inhibitor	99.97%	Yes
HY-117287	Deucravacitinib	Inhibitor	99.93%	Unkown
HY-50858	Ruxolitinib phosphate	Inhibitor	99.97%	Yes
HY-16379	Pacritinib	Inhibitor	99.93%	Yes
HY-107429	Abrocitinib	Inhibitor	99.26%	Unkown
HY-18300	Filgotinib	Inhibitor	99.77%	Yes
HY-19568	Peficitinib	Inhibitor	99.43%	Yes
HY-15315A	Baricitinib phosphate	Inhibitor	99.97%	Yes
HY-109053	Delgocitinib	Inhibitor	99.61%	Unkown
HY-13577	Oclacitinib	Inhibitor	99.03%	Unkown
HY-13577A	Oclacitinib monomaleate	Inhibitor	99.87%	Unkown
HY-18300A	Filgotinib maleate	Inhibitor	99.88%	Yes
HY-50859	Ruxolitinib sulfate	Inhibitor	/	Unkown
HY-19569A	Upadacitinib tartrate tetrahydrate	Inhibitor	/	Unkown
HY-19568A	Peficitinib hydrobromide	Inhibitor	/	Unkown
HY-16379A	Pacritinib hydrochloride	Inhibitor	/	Unkown
HY-19568B	Peficitinib hydrochloride	Inhibitor	/	Unkown

Clinical Phase

Bioactive Molecules (12)

Cat. No.	Product Name	Effect	Purity	Phase
HY-15999	Cerdulatinib	Inhibitor	99.06%	Phase 3
HY-12469	Decernotinib	Inhibitor	99.91%	Phase 3
HY-112724	Ivarmacitinib	Inhibitor	99.62%	Phase 3
HY-15999A	Cerdulatinib hydrochloride	Inhibitor	98.96%	Phase 3
HY-174905	Quecitinib	Inhibitor	99.56%	Phase 3
HY-13034	Gandotinib	Inhibitor	99.86%	Phase 2
HY-15270	BMS-911543	Inhibitor	98.23%	Phase 2
HY-19631A	Ilginatinib	Inhibitor	99.81%	Phase 2
HY-156961	Cadefrecitinib	Inhibitor	99.81%	Phase 2
HY-19631B	Ilginatinib hydrochloride	Inhibitor	98.92%	Phase 2
HY-19631	Ilginatinib maleate	Inhibitor	99.33%	Phase 2
HY-101024	PF-06263276	Inhibitor	≥99.0%	Phase 1

Pre-clinical Phase

Bioactive Molecules (57)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-14435	Pyridone 6	Inhibitor	98.20%	Unkown
HY-14722	NVP-BSK805	Inhibitor	99.30%	Unkown
HY-100895	SAR-20347	Inhibitor	97.27%	Unkown
HY-131968	BMS-986202	Inhibitor	99.29%	Unkown
HY-113787	(R)-9b	Inhibitor	99.51%	Unkown
HY-160144S	Lomedeucitinib	Inhibitor	99.75%	Unkown
HY-16640	TCJL37	Inhibitor	99.89%	Unkown
HY-14722A	NVP-BSK805 dihydrochloride	Inhibitor	99.36%	Unkown
HY-126242S	Tyk2-IN-7	Inhibitor	99.58%	Unkown
HY-101762	TyK2-IN-2	Inhibitor	99.05%	Unkown
HY-111745	Tyk2-IN-5	Inhibitor	99.35%	Unkown
HY-131906	JAK2-IN-7	Inhibitor	98.31%	Unkown
HY-150720	TYK2-IN-12	Inhibitor	98.81%	Unkown
HY-153701S	Envudeucitinibum	Inhibitor	99.56%	Unkown
HY-153440	Methyl 6-(1-(4-methoxybenzyl)-1H-pyrazol-4-yl)-4-oxo-4,5-dihydropyrazolo[1,5-a]pyrazine-2-carboxylate	Inhibitor	98.01%	Unkown
HY-120469	2,6-Dichloro-N-(2-(cyclopropanecarboxamido)pyridin-4-yl)benzamide	Inhibitor	99.80%	Unkown
HY-111750	JAK-IN-3	Inhibitor	98.92%	Unkown
HY-13961	GLPG0634 analog	Inhibitor	98.07%	Unkown
HY-126141	JAK/HDAC-IN-1	Inhibitor	98.63%	Unkown
HY-152080	Blovacitinib	Inhibitor	99.71%	Unkown
HY-159536	Frevecitinib	Inhibitor	/	Unkown
HY-170772	Dual Cathepsin L/JAK-IN-1	Inhibitor	98.47%	Unkown
HY-143884	JAK2/TYK2-IN-1	Inhibitor	99.94%	Unkown
HY-148060	JAK-IN-21	Inhibitor	99.72%	Unkown
HY-18710	BMS-066	Inhibitor	99.09%	Unkown
HY-18315	Bayer-18	Inhibitor	/	Unkown
HY-14722C	NVP-BSK805 trihydrochloride	Inhibitor	/	Unkown
HY-173359	TYK2 ligand 2	Ligand	/	Unkown
HY-154994	JAK-IN-30	Inhibitor	/	Unkown
HY-158692	Tyk2-IN-18	Inhibitor	/	Unkown
HY-153058	LRRK2-IN-8	Inhibitor	/	Unkown
HY-177131	Soficitinib	Inhibitor	/	Unkown
HY-174430	WWQ-131	Inhibitor	/	Unkown
HY-147754	JAK3/BTK-IN-6	Inhibitor	/	Unkown
HY-178282	JAK1-IN-19	Inhibitor	/	Unkown
HY-163304	Tyk2-IN-16	Inhibitor	/	Unkown
HY-149283	JAK/HDAC-IN-2	Inhibitor	/	Unkown
HY-175983	JAK1/TYK2-IN-5	Inhibitor	/	Unkown
HY-158340	TYK2 ligand 1	Inhibitor	/	Unkown
HY-18709	Tyk2-IN-3	Inhibitor	/	Unkown
HY-168339	Tyk2-IN-22	Inhibitor	/	Unkown
HY-153103	LRRK2/NUAK1/TYK2-IN-1	Inhibitor	/	Unkown
HY-N14094	Tubulosine	Inhibitor	/	Unkown
HY-177130S	Socrodeucitinib	Inhibitor	/	Unkown
HY-168269	Tyk2-IN-20	Inhibitor	/	Unkown
HY-175310S	Voderdeucitinib	Inhibitor	/	Unkown
HY-143885	JAK1/TYK2-IN-3	Inhibitor	/	Unkown
HY-149296	JAK1-IN-12	Inhibitor	/	Unkown
HY-181278	Deucravacitinib analog 1		/	Unkown
HY-112783	TYK2 ligand 4	Ligand	/	Unkown
HY-176793	JAK1-IN-18	Inhibitor	/	Unkown
HY-175684	JAK2-IN-14	Inhibitor	/	Unkown
HY-162862	JAK-IN-38	Inducer	/	Unkown
HY-123939	JAK1/3-IN-1	Inhibitor	/	Unkown
HY-123187	AS2553627	Inhibitor	/	Unkown
HY-162862	JAK-IN-38	Inhibitor	/	Unkown
HY-157121	JAK-IN-34	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	TYK2	NCBI	NCBI:7297

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