2. Epigenetics Stem Cell/Wnt Protein Tyrosine Kinase/RTK JAK/STAT Signaling
  3. JAK FLT3
  4. Pacritinib hydrochloride

Pacritinib hydrochloride  (Synonyms: SB1518 hydrochloride)

Cat. No.: HY-16379A
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Pacritinib hydrochloride is a potent inhibitor of both wild-type JAK2 (IC50=23 nM) and JAK2V617F mutant (IC50=19 nM). Pacritinib hydrochloride also inhibits FLT3 (IC50=22 nM) and its mutant FLT3D835Y (IC50=6 nM). Pacritinib hydrochloride can be used for the research of acute myeloid leukemia (AML) and myelofibrosis (MF).

For research use only. We do not sell to patients.

Pacritinib hydrochloride Chemical Structure

Pacritinib hydrochloride Chemical Structure

CAS No. : 1228923-43-0

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Pacritinib hydrochloride Related Antibodies

Top Publications Citing Use of Products

    Pacritinib hydrochloride purchased from MedChemExpress. Usage Cited in: Nat Med. 2017 Nov;23(11):1319-1330.  [Abstract]

    Pacritinib effectively disrupts the S100A7/8/9–IRAK1 feedback loop to inhibit tumorsphere growth. Representative western blot (n=2) showing inhibition of phosphorylated IRAK1 and phosphorylated JAK2 (pJAK2) within 6 h of Pacritinib treatment in MB468 and MB231 cells. Actin is used as a loading control.

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    Description

    Pacritinib hydrochloride is a potent inhibitor of both wild-type JAK2 (IC50=23 nM) and JAK2V617F mutant (IC50=19 nM). Pacritinib hydrochloride also inhibits FLT3 (IC50=22 nM) and its mutant FLT3D835Y (IC50=6 nM). Pacritinib hydrochloride can be used for the research of acute myeloid leukemia (AML) and myelofibrosis (MF)[1][2][3].

    IC50 & Target

    JAK2V617F

    19 nM (IC50)

    JAK2wt

    23 nM (IC50)

    Tyk2

    50 nM (IC50)

    JAK3

    520 nM (IC50)

    JAK1

    1280 nM (IC50)

    Clinical Trial
    Formula

    C28H32N4O3.xClH
    CAS No.
    SMILES

    [H]Cl.C1(COC/C=C/COCC2=C(OCCN3CCCC3)C=CC4=C2)=CC=CC(C5=N/C(NC=C5)=N\4)=C1.[x]
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    Please store the product under the recommended conditions in the Certificate of Analysis.
    Purity & Documentation
    References
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    Pacritinib hydrochloride Related Classifications

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    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Pacritinib1228923-43-0SB1518SB 1518SB-1518JAKFLT3Janus kinaseCluster of differentiation antigen 135CD135Fms like tyrosine kinase 3Myeloidleukemialymphoid malignanciesmyelofibrosiInhibitorinhibitorinhibit

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