NMBR - neuromedin B receptor Gene

Also Known as BB1; BB1R; BRS1; NMB-R

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 4829

About NMBR

Cytogenetic location: 6q24.1 Genomic coordinates (GRCh38): 6:142,074,484-142,147,122 (from NCBI)

This gene has 2 transcripts (splice variants), 193 orthologues and 15 paralogues. Low expression observed in reference dataset.

Summary

This gene encodes a 7-transmembrane G protein-coupled receptor that binds neuromedin B, which is a growth factor and mitogen for gastrointestinal epithelial tissue and for normal and neoplastic lung. This receptor may play a role in smooth muscle contraction, neuronal responses, and the regulation of cell growth. Antagonists of this receptor have a potential therapeutic use in inhibiting tumor cell growth. Polymorphisms in this gene may be associated with a susceptibility for schizophrenia. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2016]

NMBR Products (3)

mRNA Protein Name
NM_001324307.2 NP_001311236.1 neuromedin-B receptor isoform b precursor
NM_001324308.2 NP_001311237.1 neuromedin-B receptor isoform b precursor
NM_002511.4 NP_002502.2 neuromedin-B receptor isoform a

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
involved in antiviral innate immune response IMP
IMP: Inferred from mutant phenotype
31601264 GOA
involved in negative regulation of interleukin-6 production IMP
IMP: Inferred from mutant phenotype
31601264 GOA
involved in positive regulation of interferon-alpha production IMP
IMP: Inferred from mutant phenotype
31601264 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NMBR Protein Structure

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (60 - 322)

  • 0
  • 100
  • 200
  • 300
  • 390 a.a.
Protein Preferred Names Protein Names

neuromedin-B receptor

  • bombesin receptor 1

Related Diseases

Diseases Alias
Breast Osteosarcoma

  • Osteogenic Sarcoma Of Breast

  • Breast Extraskeletal Osteosarcoma
Gastrinoma

  • Gastrin Cell Tumour

  • Gastrin Secreting Tumor

  • Malignant Gastrinoma

  • Gastrinoma, Malignant
Lung Cancer

  • Lung Carcinoma

  • Non-Small Cell Lung Carcinoma

  • Lung Cancer, Susceptibility To

  • Lung Cancer, Protection Against

  • Adenocarcinoma Of Lung, Somatic

  • Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

  • Nonsmall Cell Lung Cancer

  • Lung Neoplasm

  • Carcinoma Of Lung

  • Lung Non-Small Cell Carcinoma

  • Non-Small Cell Lung Cancer

  • Nsclc

  • Lung Neoplasms

  • Malignant Neoplasm Of Lung

  • Alveolar Cell Carcinoma

  • Nonsmall Cell Lung Cancer, Somatic

  • Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

  • Nonsmall Cell Lung Cancer, Susceptibility To

  • Lung Cancer, Somatic

  • Lung Cancer, Resistance To

  • Cancer Of Lung

  • Cancer Of Bronchus

  • Cancer Of The Lung

  • Lung Malignancies

  • Lung Malignant Tumors

  • Malignant Lung Tumor

  • Malignant Tumor Of Lung

  • Pulmonary Cancer

  • Pulmonary Carcinoma

  • Pulmonary Neoplasms

  • Respiratory Carcinoma

  • LNCR

  • Adenocarcinoma Of Lung

  • Neoplasm Of Lung

  • Cancer Lung

  • Carcinoma Non-Small Cell Lung

  • Carcinoma, Non-Small-Cell Lung

  • Lung Cancers

  • Lung Carcinomas

  • Cancer, Lung

  • Cancer, Lung, Non-Small Cell

  • Primary Malignant Neoplasm Of Lung

  • Bronchioloalveolar Adenocarcinoma
Intellectual Developmental Disorder, Autosomal Dominant 41

  • MRD41

  • Autosomal Dominant Non-Syndromic Intellectual Disability 41

  • Mental Retardation, Autosomal Dominant 41

  • Autosomal Dominant Intellectual Developmental Disorder 41

  • Autosomal Dominant Mental Retardation 41

  • Mental Retardation, Autosomal Dominant, Type 41
Schizophrenia

  • SCZD

  • Schizophrenia With Or Without An Affective Disorder

  • Schizophrenia 12

  • Schizophrenia, Susceptibility To

  • Schizophrenia-1

  • Dementia Praecox

  • Schizophrenia 1
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (12)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-116216 PD 168368 Antagonist ≥99.0% Unkown
HY-122351A Advantame 99.27% Unkown
HY-P1423A BA 1 TFA Agonist 99.35% Unkown
HY-N2600 Kuwanon H 98.60% Unkown
HY-103277A BIM 23042 TFA Antagonist 99.75% Unkown
HY-122351 Advantame free acid 98.00% Unkown
HY-103277 BIM 23042 Antagonist / Unkown
HY-N2600R Kuwanon H (Standard) / Unkown
HY-P1423 BA 1 Agonist / Unkown
HY-RS09369 NMBR Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17815 Nmbr Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24284 Nmbr Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus NMBR RGD RGD:3181
Canis familiaris NMBR VGNC VGNC:43855
Felis catus NMBR VGNC VGNC:68502
Bos taurus NMBR VGNC VGNC:32124
Mus musculus NMBR MGD MGI:1100525
Macaca mulatta NMBR VGNC VGNC:104416
Others NMBR NCBI