2. Gene
  3. NRDC - nardilysin convertase Gene

NRDC - nardilysin convertase Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as NRD1; hNRD1; hNRD2

Gene ID: 4898 | Gene type: protein coding

About NRDC

Cytogenetic location: 1p32.3 Genomic coordinates (GRCh38): 1:51,789,210-51,878,727 (from NCBI)

This gene has 13 transcripts (splice variants), 292 orthologues and 6 paralogues. Ubiquitous expression in testis (RPKM 55.2), skin (RPKM 27.3) and 25 other tissues.

Summary

This gene encodes a zinc-dependent endopeptidase that cleaves peptide substrates at the N-terminus of arginine residues in dibasic moieties and is a member of the peptidase M16 family. This protein interacts with heparin-binding EGF-like growth factor and plays a role in cell migration and proliferation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011]

NRDC Products(3)

mRNA Protein Name
NM_001101662.2 NP_001095132.1 nardilysin isoform b precursor
NM_001242361.2 NP_001229290.1 nardilysin isoform c
NM_002525.3 NP_002516.2 nardilysin isoform a

NRDC Protein Structure

Peptidase_M16

Peptidase_M16: Insulinase (Peptidase family M16) (277 - 404)

Peptidase_M16_C

Peptidase_M16_C: Peptidase M16 inactive domain (431 - 614)

Peptidase_M16_C

Peptidase_M16_C: Peptidase M16 inactive domain (907 - 1087)

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  • 1219 a.a.
Protein Preferred Names Protein Names

nardilysin

NRD convertase

Related Agents

Approval
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B0887 Permethrin Inhibitor ≥98.0% Unkown
Pre-clinical Phase
Bioactive Molecules (8)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-W588212 trans-Permethrin Inhibitor 99.88% Unkown
HY-B0887S Permethrin-d5 Inhibitor ≥98.0% Unkown
HY-B0887C 1R-cis-Permethrin Inhibitor 99.89% Unkown
HY-B0887D (-)-cis-Permethrin 98.09% Unkown
HY-B0887S1 Permethrin-d9 Inhibitor / Unkown
HY-RS09564 NRDC Human Pre-designed siRNA Set A / Unkown
HY-B0887A (+)-trans-Permethrin 99.33% Unkown
HY-B0887B (-)-trans-Permethrin 99.76% Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus NRDC RGD RGD:3210
Mus musculus NRDC MGD MGI:1201386
Bos taurus NRDC VGNC VGNC:32258
Canis familiaris NRDC VGNC VGNC:43964
Felis catus NRDC VGNC VGNC:68562
Macaca mulatta NRDC VGNC VGNC:75526