NRDC - nardilysin convertase Gene

Also Known as NRD1; hNRD1; hNRD2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 4898

About NRDC

Cytogenetic location: 1p32.3 Genomic coordinates (GRCh38): 1:51,789,210-51,878,727 (from NCBI)

This gene has 13 transcripts (splice variants), 292 orthologues and 6 paralogues. Ubiquitous expression in testis (RPKM 55.2), skin (RPKM 27.3) and 25 other tissues.

Summary

This gene encodes a zinc-dependent endopeptidase that cleaves peptide substrates at the N-terminus of arginine residues in dibasic moieties and is a member of the peptidase M16 family. This protein interacts with heparin-binding EGF-like growth factor and plays a role in cell migration and proliferation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011]

NRDC Products (3)

mRNA Protein Name
NM_001101662.2 NP_001095132.1 nardilysin isoform b precursor
NM_001242361.2 NP_001229290.1 nardilysin isoform c
NM_002525.3 NP_002516.2 nardilysin isoform a

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
18355445 GOA
Biological Process GO Annotation Evidence References Source
involved in positive regulation of membrane protein ectodomain proteolysis IDA
IDA: Inferred from direct assay
18355445 GOA
involved in regulation of endopeptidase activity IDA
IDA: Inferred from direct assay
18355445 GOA
Cellular Component GO Annotation Evidence References Source
is active in mitochondrial matrix IDA
IDA: Inferred from direct assay
28017472 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NRDC Protein Structure

Peptidase_M16

Peptidase_M16: Insulinase (Peptidase family M16) (277 - 404)

Peptidase_M16_C

Peptidase_M16_C: Peptidase M16 inactive domain (431 - 614)

Peptidase_M16_C

Peptidase_M16_C: Peptidase M16 inactive domain (907 - 1087)

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  • 1219 a.a.
Protein Preferred Names Protein Names

nardilysin

  • NRD convertase

NRDC Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
NRDC O43847 TP53 Homo sapiens P04637
Anti Bait CoIP
22653443
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B0887 Permethrin 99.84% Unkown

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-B0887C 1R-cis-Permethrin Inhibitor 99.89% Phase 4

Pre-clinical Phase

Bioactive Molecules (8)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-B0887S Permethrin-d5 Inhibitor 99.21% Unkown
HY-B0887A (+)-trans-Permethrin 99.33% Unkown
HY-B0887B (-)-trans-Permethrin 99.79% Unkown
HY-B0887D (-)-cis-Permethrin 98.19% Unkown
HY-W588212 trans-Permethrin Inhibitor 99.88% Unkown
HY-B0887S1 Permethrin-d9 Inhibitor 98.20% Unkown
HY-RS09564 NRDC Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W774926 Permethrin-d6 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus NRDC RGD RGD:3210
Mus musculus NRDC MGD MGI:1201386
Bos taurus NRDC VGNC VGNC:32258
Canis familiaris NRDC VGNC VGNC:43964
Felis catus NRDC VGNC VGNC:68562
Macaca mulatta NRDC VGNC VGNC:75526
Others NRDC NCBI