Permethrin-d5
Based on 1 Customer Validation
Permethrin-d5 (NRDC-143-d5) is the deuterium labeled Permethrin. Permethrin (NRDC-143) is an insecticide, acaricide, and insect repellent; functions as a neurotoxin, affecting neuron membranes by prolonging sodium channel activation.
For research use only. We do not sell to patients.
- Purity: 99.21%
- CAS No.: 1794760-19-2
- Formula: C21H15D5Cl2O3
- Molecular Weight:396.32
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 1794760-19-2
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Unlabeled Cas 52645-53-1
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Appearance Solid
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Molecular Weight 396.32
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Formula C21H15D5Cl2O3
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Color White to off-white
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SMILES
C(=C(Cl)Cl)C1C(C(OCC2=CC(OC3=C(C(=C(C(=C3[2H])[2H])[2H])[2H])[2H])=CC=C2)=O)C1(C)C
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Synonyms
NRDC-143-d5
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 50 mg/mL (126.16 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (270 KB)
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SDS (597 KB)
- English - EN (597 KB)
- Français - FR (597 KB)
- Deutsch - DE (597 KB)
- Norwegian - NO (597 KB)
- Español - ES (597 KB)
- Swedish - SV (597 KB)
- Italian - IT (597 KB)
- Korean - KR (597 KB)
- Portuguese - PT (597 KB)
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Handling Instructions (2659 KB)
References
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
[2]. Xiao X, et al. Exposure to permethrin promotes high fat diet-induced weight gain and insulin resistance in male C57BL/6J mice. Food Chem Toxicol. 2018 Jan;111:405-416. [Content Brief]
[3]. Smith LB, et al. CYP-mediated permethrin resistance in Aedes aegypti and evidence for trans-regulation. PLoS Negl Trop Dis. 2018 Nov 19;12(11):e0006933. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.5232 mL | 12.6161 mL | 25.2321 mL | 63.0803 mL |
| 5 mM | 0.5046 mL | 2.5232 mL | 5.0464 mL | 12.6161 mL | |
| 10 mM | 0.2523 mL | 1.2616 mL | 2.5232 mL | 6.3080 mL | |
| 15 mM | 0.1682 mL | 0.8411 mL | 1.6821 mL | 4.2054 mL | |
| 20 mM | 0.1262 mL | 0.6308 mL | 1.2616 mL | 3.1540 mL | |
| 25 mM | 0.1009 mL | 0.5046 mL | 1.0093 mL | 2.5232 mL | |
| 30 mM | 0.0841 mL | 0.4205 mL | 0.8411 mL | 2.1027 mL | |
| 40 mM | 0.0631 mL | 0.3154 mL | 0.6308 mL | 1.5770 mL | |
| 50 mM | 0.0505 mL | 0.2523 mL | 0.5046 mL | 1.2616 mL | |
| 60 mM | 0.0421 mL | 0.2103 mL | 0.4205 mL | 1.0513 mL | |
| 80 mM | 0.0315 mL | 0.1577 mL | 0.3154 mL | 0.7885 mL | |
| 100 mM | 0.0252 mL | 0.1262 mL | 0.2523 mL | 0.6308 mL |
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