Nox4 - NADPH oxidase 4 Gene

Species: Mus musculus

Gene Type: protein coding

Gene ID: 50490

About Nox4

Chromosome 7: 86,895,304-87,047,918 forward strand.GRCm39:CM001000.3

This gene has 8 transcripts (splice variants), 149 orthologues, 5 paralogues and is associated with 31 phenotypes. Biased expression in kidney adult (RPKM 51.3) and lung adult (RPKM 5.1).

Summary

Enables protein tyrosine kinase binding activity and superoxide-generating NAD(P)H oxidase activity. Involved in several processes, including positive regulation of intracellular signal transduction; positive regulation of nitrogen compound metabolic process; and superoxide anion generation. Acts upstream of or within bone resorption; cardiac muscle cell differentiation; and cellular response to glucose stimulus. Located in several cellular components, including mitochondrion; nucleus; and perinuclear region of cytoplasm. Is expressed in embryo; heart; metanephros; renal cortex; and ventricle compact myocardium. Orthologous to human NOX4 (NADPH Oxidase 4). [provided by Alliance of Genome Resources, Apr 2022]

Nox4 Products (3)

mRNA	Protein	Name
NM_001285833.1	NP_001272762.1	NADPH oxidase 4 isoform 2
NM_001285835.1	NP_001272764.1	NADPH oxidase 4 isoform 3
NM_015760.5	NP_056575.1	NADPH oxidase 4 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein tyrosine kinase binding	IPI IPI: Inferred from physical interaction	27525436	MGI
enables superoxide-generating NAD(P)H oxidase activity	IMP IMP: Inferred from mutant phenotype	11098048	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within bone resorption	IMP IMP: Inferred from mutant phenotype	11098048	MGI
acts upstream of or within cardiac muscle cell differentiation	IMP IMP: Inferred from mutant phenotype	16775014	MGI
involved in cell morphogenesis	IMP IMP: Inferred from mutant phenotype	10869423	MGI
involved in cellular response to glucose stimulus	IEP IEP: Inferred from expression pattern	18431508	MGI
involved in heart process	IGI IGI: Inferred from genetic interaction	27525436	MGI
involved in negative regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	10869423	MGI
involved in positive regulation of DNA biosynthetic process	IMP IMP: Inferred from mutant phenotype	17942966	MGI
involved in positive regulation of ERK1 and ERK2 cascade	IMP IMP: Inferred from mutant phenotype	17942966	MGI
involved in positive regulation of MAP kinase activity	IMP IMP: Inferred from mutant phenotype	17942966	MGI
involved in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP IMP: Inferred from mutant phenotype	17942966	MGI
involved in positive regulation of protein tyrosine kinase activity	IDA IDA: Inferred from direct assay	27525436	MGI
involved in reactive oxygen species metabolic process	IMP IMP: Inferred from mutant phenotype	17942966	MGI
involved in superoxide anion generation	IDA IDA: Inferred from direct assay	10869423	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in cell periphery	IDA IDA: Inferred from direct assay	18431508	MGI
located in mitochondrion	IDA IDA: Inferred from direct assay	23624625	MGI
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	18431508	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Nox4 Protein Structure

Ferric_reduct

NOX_Duox_like_FAD_NADP

0
100
200
300
400
500
578 a.a.

Protein Preferred Names	Protein Names
NADPH oxidase 4	KOX-1 kidney oxidase-1 kidney superoxide-producing NADPH oxidase renal NAD(P)H-oxidase superoxide-generating NADPH oxidase 4

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-12298	Setanaxib	Inhibitor	99.81%	Phase 2
HY-120801A	APX-115 free base	Inhibitor	99.54%	Phase 2

Pre-clinical Phase

Bioactive Molecules (11)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-100111	GLX351322	Inhibitor	99.48%	Unkown
HY-120801	APX-115	Inhibitor	99.90%	Unkown
HY-101499	GKT136901	Inhibitor	99.33%	Unkown
HY-152026	NADPH oxidase-IN-1	Inhibitor	99.69%	Unkown
HY-N3239	Mulberrofuran G	Inhibitor	97.86%	Unkown
HY-105946	Hidrosmin	Inhibitor	95.34%	Unkown
HY-174817	NOX5-IN-1	Inhibitor	/	Unkown
HY-N9097	Niazirin	Inhibitor	99.9%	Unkown
HY-174818	NOX5-IN-2	Inhibitor	/	Unkown
HY-124487	GK-136901	Inhibitor	/	Unkown
HY-148936	GLX481372	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Nox4	NCBI	NCBI:50507