NOX4 - NADPH oxidase 4 Gene

Also Known as KOX; KOX-1; RENOX

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 50507

About NOX4

Cytogenetic location: 11q14.3 Genomic coordinates (GRCh38): 11:89,324,353-89,589,557 (from NCBI)

This gene has 15 transcripts (splice variants), 149 orthologues and 6 paralogues. Biased expression in kidney (RPKM 23.6) and endometrium (RPKM 1.5).

Summary

This gene encodes a member of the NOX-family of Enzymes that functions as the catalytic subunit the NADPH Oxidase complex. The encoded protein is localized to non-phagocytic cells where it acts as an oxygen sensor and catalyzes the reduction of molecular oxygen to various Reactive Oxygen Species (ROS). The ROS generated by this protein have been implicated in numerous biological functions including signal transduction, cell differentiation and tumor cell growth. A pseudogene has been identified on the Other arm of chromosome 11. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Jan 2009]

NOX4 Products (9)

mRNA	Protein	Name
NR_120406.2
XM_017017843.3	XP_016873332.1	NADPH oxidase 4 isoform X1
NM_001291929.2	NP_001278858.2	NADPH oxidase 4 isoform f
NM_001291926.2	NP_001278855.2	NADPH oxidase 4 isoform d
NM_001143837.2	NP_001137309.2	NADPH oxidase 4 isoform c
NM_016931.5	NP_058627.2	NADPH oxidase 4 isoform a
NM_001291927.1	NP_001278856.1	NADPH oxidase 4 isoform e
NM_001300995.1	NP_001287924.1	NADPH oxidase 4 isoform g
NM_001143836.3	NP_001137308.2	NADPH oxidase 4 isoform b

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables NAD(P)H oxidase H2O2-forming activity	IDA IDA: Inferred from direct assay	14966267	GOA
enables NAD(P)H oxidase H2O2-forming activity	IMP IMP: Inferred from mutant phenotype	21343298	GOA
enables heme binding	IDA IDA: Inferred from direct assay	25062272	GOA
enables modified amino acid binding	IDA IDA: Inferred from direct assay	20031578	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	15356101	GOA
NOT enables superoxide-generating NAD(P)H oxidase activity	IDA IDA: Inferred from direct assay	15721269	GOA
enables superoxide-generating NAD(P)H oxidase activity	IDA IDA: Inferred from direct assay	10869423	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in gene expression	IMP IMP: Inferred from mutant phenotype	23144758	GOA
involved in heart process	IGI IGI: Inferred from genetic interaction	27525436	GOA
involved in homocysteine metabolic process	IDA IDA: Inferred from direct assay	20031578	GOA
involved in superoxide metabolic process	IDA IDA: Inferred from direct assay	18760347	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	21343298	GOA
located in endoplasmic reticulum membrane	IDA IDA: Inferred from direct assay	15927447	GOA
located in nucleolus	IDA IDA: Inferred from direct assay	23393389	GOA
located in nucleus	IDA IDA: Inferred from direct assay	16324151	GOA
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	15721269	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	16019190	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NOX4 Protein Structure

Ferric_reduct

FAD_binding_8

NAD_binding_6

0
100
200
300
400
500
578 a.a.

Protein Preferred Names	Protein Names
NADPH oxidase 4	kidney oxidase-1 kidney superoxide-producing NADPH oxidase renal NAD(P)H-oxidase

NOX4 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80762	NADPH Oxidase 4 Antibody	WB, IHC-P, ICC/IF, IP	Human, Mouse, Rat
HY-P80762A	NADPH Oxidase 4 Antibody (YA4640)	WB, IHC-P, ICC/IF, IP	Human, Mouse, Rat
HY-P84816	NADPH Oxidase 4 Antibody (YA4513)	IHC-P, ICC/IF, FC, ELISA	Human
HY-P84816A	NADPH Oxidase 4 Antibody (YA4513)(PBS only)	IHC-P, ICC/IF, FC, ELISA	Human
HY-P86600	NADPH oxidase 4 Antibody (YA6292)	WB, ICC/IF, IP, ELISA	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Ureteral Obstruction
Dilated Cardiomyopathy	Familial Dilated Cardiomyopathy Primary Dilated Cardiomyopathy Idiopathic Dilated Cardiomyopathy Congestive Cardiomyopathy Idiopathic Dilation Cardiomyopathy Primary Familial Dilated Cardiomyopathy Cardiomyopathy, Dilated DCM Cardiomyopathy, Familial Dilated Dilated Cardiomyopathy, Familial Hypokinetic Dilated Cardiomyopathy, Familial Familial Idiopathic Cardiomyopathy Fdc Cardiomyopathy, Familial Idiopathic Idiopathic Cardiomegaly Dilated Congestive Cardiomyopathy Chronic Dilated Cardiomyopathy Ccm - [Congestive Cardiomyopathy] Cocm - [Congestive Cardiomyopathy] Dcm - [Dilated Cardiomyopathy] Dilated-Hypokinetic Cardiomyopathy Congestive Idiopathic Cardiomyopathy Primary Idiopathic Dilated Cardiomyopathy
Renal Hypertension	Hypertension Renal Hypertension, Renal
Chronic Granulomatous Disease	Cgd Granulomatous Disease, Chronic Autosomal Recessive Chronic Granulomatous Disease X-Linked Chronic Granulomatous Disease Bridges-Good Syndrome Congenital Dysphagocytosis Quie Syndrome Chronic Septic Granulomatosis Chronic Granulomatous Disorder Granulomatous Disease Chronic Granulomatous Disease, Chronic, X-Linked
Pulmonary Hypertension	Primary Pulmonary Hypertension Hypertension Pulmonary Hypertension, Pulmonary Idiopathic Pulmonary Hypertension Idiopathic Pulmonary Arterial Hypertension Pulmonary Htn - [Hypertension]
Hypertension, Essential	Essential Hypertension Hypertension High Blood Pressure Hypertension, Essential, Susceptibility To Hypertensive Disease Primary Hypertension EHT Hypertension, Salt-Sensitive Essential, Susceptibility To Hyperpiesia Idiopathic Hypertension Hypertensive Disorder Hypertension, Essential, Susceptibility To, 3 Hypertension, Essential 3 Hypertension, Essential, Salt-Sensitive Hypertension, Essential, Susceptibility To, 6 Hypertension, Essential 6 Hypertension, Salt-Sensitive Essential Hypertension, Susceptibility To Hypertension, Essential, Susceptibility To, 4 Hypertension, Essential 4 Hypertension, Essential, Susceptibility To, 2 Hypertension, Essential 2 Hypertension, Essential, Susceptibility To, 1 Hypertension, Essential 1 Hypertension, Essential, Susceptibility To, 5 Hypertension, Essential 5 Htn Vascular Hypertensive Disorder Systemic Primary Arterial Hypertension Hbp - [High Blood Pressure] Systemic Arterial Hypertensive Disorder Elevated Blood Pressure Arterial Hypertension Nos Hypertension Nos Benign Hypertension Systemic Arterial Hypertension Systemic Hypertension Artery Htn Benign Htn Vascular Htn Vascular Hypertension Cholesterol Hypertension Cholesterol Htn Idiopathic Htn Malignant Hypertension Malignant Htn Raised Blood Pressure Cardiovascular Hypertension Primary Htn - [Hypertension] High Arterial Tension High Blood Pressure Disorder Ht - [Hypertension] Htn - [Hypertension] Hypertensive Vascular Disease Hypertensive Vascular Degeneration
Kidney Hypertrophy	Hypertrophy Of Kidney
Interstitial Lung Disease 2	Idiopathic Pulmonary Fibrosis Ipf Fibrocystic Pulmonary Dysplasia Pulmonary Fibrosis, Idiopathic Pulmonary Fibrosis, Idiopathic, Susceptibility To ILD2 Idiopathic Pulmonary Fibrosis, Familial Fibrosing Alveolitis, Cryptogenic Uip Cryptogenic Fibrosing Alveolitis Fibrosing Alveolitis Interstitial Pneumonitis, Usual Familial Idiopathic Pulmonary Fibrosis Idiopathic Fibrosing Alveolitis, Chronic Form Usual Interstitial Pneumonia Fibrosing Alveolitis Cryptogenic Hamman-Rich Disease Idiopathic Pulmonary Fibrosis Familial Interstitial Pneumonitis Usual Fibrosis Idiopathic Pulmonary Fibrosis, Pulmonary, Idiopathic Hamman-Rich Syndrome Chronic Idiopathic Pulmonary Fibrosis Acute Interstitial Pneumonia Interstitial Pulmonary Fibrosis Ipf - [Idiopathic Pulmonary Fibrosis] Idiopathic Lung Fibrosis Fibrosing Lung Disease Pulmonary Fibrosis Nos Fibrosing Pneumonitis
Type 2 Diabetes Mellitus	Insulin Resistance NIDDM Diabetes Mellitus, Non-Insulin-Dependent Type 2 Diabetes T2D Noninsulin-Dependent Diabetes Mellitus Diabetes Mellitus, Type Ii Maturity-Onset Diabetes Insulin Resistance, Severe, Digenic Diabetes Mellitus, Type 2 Diabetes Mellitus, Noninsulin-Dependent Diabetes Mellitus, Noninsulin-Dependent, Association With Diabetes Mellitus, Noninsulin-Dependent, Late Onset Hypertension, Insulin Resistance-Related, Susceptibility To Insulin Resistance, Susceptibility To Non-Insulin-Dependent Diabetes Mellitus Type Ii Diabetes Mellitus Adult-Onset Diabetes Mellitus Maturity-Onset Diabetes Mellitus Diabetes Mellitus Type 2 Type Ii Diabetes Type 2 Diabetes Mellitus, Susceptibility To Diabetes, Type 2 Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To Diabetes Mellitus, Type 2, Susceptibility To Diabetes Mellitus, Noninsulin-Dependent, 2 Diabetes Mellitus, Type Ii, Susceptibility To Hypertension, Insulin Resistance-Related Adult-Onset Diabetes Aodm Diabetes Mellitus, Adult-Onset Diabetes Mellitus Type Ii Diabetes Mellitus Type 2, Susceptibility To Diabetes, Type Ii, Susceptibility To Diabetes Type 2 Diabetes Mellitus Adult Onset Diabetes Maturity Onset Diabetes Nonketotic Diabetes Non-Insulin Dependent Diabetes Mellitus T2dm - [Type 2 Diabetes Mellitus] Niddm - [Non Insulin Dependent Diabetes Mellitus] Dm2 Dm Type Ii Diabetic Type 2 Insulin Requiring Type 2 Diabetes Noninsulin Dependent Diabetes Non-Insulin-Dependent Diabetes Mellitus Without Complications Diabetes Due To Insulin Secretory Defect Diabetes Mellitus Due To Insulin Secretory Defect Non-Insulin-Dependent Diabetes Of The Young Senile Diabetes Nonketotic Hyperglycaemia Stable Diabetes
Osteoporosis	Postmenopausal Osteoporosis Osteoporosis, Postmenopausal Bone Mineral Density Quantitative Trait Locus Bmnd Osteoporosis, Involutional Osteoporosis, Susceptibility To Osteoporosis, Postmenopausal, Susceptibility Bone Mineral Density Variation Qtl, Osteoporosis OSTEOP Involutional Osteoporosis Senile Osteoporosis Osteoporosis Postmenopausal Bone Mineral Density, Quantitative Trait Locus Osteoporosis, Senile Idiopathic Osteoporosis Bone Rarefaction Nos Type 1 Osteoporosis
Aortic Aneurysm, Familial Thoracic 1	Thoracic Aortic Aneurysm Annuloaortic Ectasia Familial Thoracic Aortic Aneurysm And Aortic Dissection Familial Aortic Dissection Familial Taad Congenital Aneurysm Of Ascending Aorta Familial Aortic Aneurysm Familial Thoracic Aortic Aneurysm Familial Thoracic Aortic Aneurysm And Dissection Aortic Aneurysm, Thoracic AAT1 Faa1 Aortic Dissection, Familial Aortic Aneurysm, Familial Thoracic Aneurysm, Thoracic Aortic Faa Ftaad Taa Taad Cystic Medial Necrosis Of Aorta Familial Non-Syndromic Thoracic Aortic Aneurysm And Aortic Dissection Aortic Aneurysm Thoracic Familial Aortic Aneurysms Aneurysm, Aortic, Thoracic, Familial, Type 1 Aneurysm Of Thoracic Aorta Intrathoracic Aneurysm Thoracic Aorta Aneurysm Thoracic Aortic Aneurysm Without Rupture Thoracic Aneurysm Thorax Arterial Aneurysm Thoracic Artery Aneurysm Thoracic Arterial Aneurysm Thorax Aneurysm Thorax Aortic Aneurysm Dissection Of Thoracic Aorta
Asbestosis	Idiopathic Interstitial Pneumonitis - From Asbestos Exposure Pulmonary Fibrosis - From Asbestos Exposure
Renovascular Hypertension	Hypertension, Renovascular Hypertension Renovascular
Nervous System Disease	Abnormality Of The Nervous System Nervous System Diseases Nervous System Disorder
Vascular Disease	Vascular Diseases Aneurysm Spinal Cord Ischemia Spinal Cord Vascular Diseases Vascular Tissue Disease Vascular Anomaly
Orthostatic Intolerance	Mitral Valve Prolapse Neurocirculatory Asthenia Mitral Valve Prolapse Syndrome Irritable Heart Systolic Click-Murmur Syndrome Soldiers Heart Cardiovascular Malfunction Arising From Mental Factors Cardiovascular Neurosis Da Costa'S Syndrome Krishaber'S Disease Barlow'S Syndrome Floppy Mitral Valve Mitral Leaflet Syndrome Myxomatous Mitral Valve Prolapse Postural Orthostatic Tachycardia Syndrome Due To Net Deficiency Familial Orthostatic Tachycardia Due To Norepinephrine Transporter Deficiency Orthostatic Intolerance Due To Net Deficiency Pots Due To Net Deficiency OI Intolerance, Orthostatic Mitral Valve Prolapse, Familial, X-Linked Ballooning Mitral Valve Barlow Syndrome Flail Mitral Leaflet Myxomatous Mitral Valve Mitral Valve Prolapse-Click Syndrome Prolapsing Mitral Valve Leaflet Syndrome Billowing Mitral Valve Leaflet Posterior Mitral Leaflet Deformity Ballooning Posterior Leaflet Syndrome Blue Valve Syndrome Floppy Mitral Valve Syndrome Mitral Valvular Prolapse Systolic Click Syndrome
Alcoholic Cardiomyopathy	Cardiomyopathy, Alcoholic Alcohol-Induced Heart Muscle Disease Dilated Cardiomyopathy Secondary To Alcohol

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-12298	Setanaxib	Inhibitor	99.81%	Phase 2
HY-120801A	APX-115 free base	Inhibitor	99.54%	Phase 2

Pre-clinical Phase

Bioactive Molecules (11)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-100111	GLX351322	Inhibitor	99.48%	Unkown
HY-120801	APX-115	Inhibitor	99.90%	Unkown
HY-101499	GKT136901	Inhibitor	99.33%	Unkown
HY-152026	NADPH oxidase-IN-1	Inhibitor	99.69%	Unkown
HY-N3239	Mulberrofuran G	Inhibitor	97.86%	Unkown
HY-105946	Hidrosmin	Inhibitor	95.34%	Unkown
HY-174817	NOX5-IN-1	Inhibitor	/	Unkown
HY-N9097	Niazirin	Inhibitor	99.9%	Unkown
HY-174818	NOX5-IN-2	Inhibitor	/	Unkown
HY-124487	GK-136901	Inhibitor	/	Unkown
HY-148936	GLX481372	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	NOX4	RGD	RGD:620600
Bos taurus	NOX4	VGNC	VGNC:32184
Macaca mulatta	NOX4	VGNC	VGNC:75376
Canis familiaris	NOX4	VGNC	VGNC:43905
Felis catus	NOX4	VGNC	VGNC:68524
Mus musculus	NOX4	MGD	MGI:1354184
Others	NOX4	NCBI