ITSN2 - intersectin 2 Gene

Also Known as SWA; SWAP; SH3D1B; SH3P18; PRO2015

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 50618

About ITSN2

Cytogenetic location: 2p23.3 Genomic coordinates (GRCh38): 2:24,202,864-24,361,368 (from NCBI)

This gene has 12 transcripts (splice variants), 293 orthologues and 10 paralogues. Ubiquitous expression in thyroid (RPKM 16.9), lymph node (RPKM 13.9) and 25 other tissues.

Summary

This gene encodes a cytoplasmic protein which contains SH3 domains. This protein is a member of a family of proteins involved in clathrin-mediated endocytosis. Intersectin 2 is thought to regulate the formation of clathrin-coated vesicles and also may function in the induction of T cell antigen receptor (TCR) endocytosis. [provided by RefSeq, Jan 2017]

ITSN2 Products (9)

mRNA Protein Name
NM_001348181.2 NP_001335110.1 intersectin-2 isoform 4
NM_001348182.2 NP_001335111.1 intersectin-2 isoform 5
NM_001348183.2 NP_001335112.1 intersectin-2 isoform 6
NM_001348184.2 NP_001335113.1 intersectin-2 isoform 7
NM_001348185.2 NP_001335114.1 intersectin-2 isoform 8
NM_001348186.2 NP_001335115.1 intersectin-2 isoform 9
NM_006277.3 NP_006268.2 intersectin-2 isoform 1
NM_019595.4 NP_062541.3 intersectin-2 isoform 3
NM_147152.3 NP_671494.2 intersectin-2 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
17696407 GOA
Biological Process GO Annotation Evidence References Source
involved in positive regulation of dendrite extension IDA
IDA: Inferred from direct assay
23999003 GOA
Cellular Component GO Annotation Evidence References Source
located in centrosome IDA
IDA: Inferred from direct assay
20479469 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ITSN2 Protein Structure

EF-hand_4

EF-hand_4: Cytoskeletal-regulatory complex EF hand (19 - 91)

EF-hand_4

EF-hand_4: Cytoskeletal-regulatory complex EF hand (247 - 330)

SH3_9

SH3_9: Variant SH3 domain (764 - 814)

SH3_2

SH3_2: Variant SH3 domain (903 - 953)

SH3_1

SH3_1: SH3 domain (987 - 1031)

SH3_1

SH3_1: SH3 domain (1063 - 1109)

SH3_9

SH3_9: Variant SH3 domain (1134 - 1182)

RhoGEF

RhoGEF: RhoGEF domain (1214 - 1394)

C2

C2: C2 domain (1571 - 1651)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1500
  • 1697 a.a.
Protein Preferred Names Protein Names

intersectin-2

  • SH3 domain-containing protein 1B

ITSN2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
ITSN2 Q9NZM3 EPS15L1 Homo sapiens Q9UBC2
Anti Tag CoIP
35271311
Intra
ITSN2 Q9NZM3 EGFR Homo sapiens P00533
Ub Reconstruction
24658140
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Nephrotic Syndrome, Type 22

  • NPHS22

  • Nephrotic Syndrome Type 22

  • Nephrotic Syndrome 22
Chromosome 17q12 Deletion Syndrome

  • 17q12 Microdeletion Syndrome

  • Del(17)(Q12)

  • Monosomy 17q12
Nephrotic Syndrome, Type 21

  • NPHS21

  • Nephrotic Syndrome Type 21

  • Nephrotic Syndrome 21
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06998 ITSN2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus ITSN2 VGNC VGNC:67873
Bos taurus ITSN2 VGNC VGNC:30353
Macaca mulatta ITSN2 VGNC VGNC:73807
Rattus norvegicus ITSN2 RGD RGD:1590890
Mus musculus ITSN2 MGD MGI:1338049
Canis familiaris ITSN2 VGNC VGNC:42162
Others ITSN2 NCBI