PDK4 - pyruvate dehydrogenase kinase 4 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 5166

About PDK4

Cytogenetic location: 7q21.3 Genomic coordinates (GRCh38): 7:95,583,499-95,596,516 (from NCBI)

This gene has 5 transcripts (splice variants), 210 orthologues and 4 paralogues. Broad expression in fat (RPKM 319.9), adrenal (RPKM 136.4) and 18 other tissues.

Summary

This gene is a member of the PDK/BCKDK protein kinase family and encodes a mitochondrial protein with a histidine kinase domain. This protein is located in the matrix of the mitrochondria and inhibits the pyruvate dehydrogenase complex by phosphorylating one of its subunits, thereby contributing to the regulation of glucose metabolism. Expression of this gene is regulated by glucocorticoids, retinoic acid and Insulin. [provided by RefSeq, Jul 2008]

PDK4 Products (1)

mRNA Protein Name
NM_002612.4 NP_002603.1 pyruvate dehydrogenase kinase, isozyme 4

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables ATP binding IDA
IDA: Inferred from direct assay
18658136 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
enables protein kinase activity IDA
IDA: Inferred from direct assay
18658136 GOA
Biological Process GO Annotation Evidence References Source
involved in cellular response to fatty acid IMP
IMP: Inferred from mutant phenotype
20715114 GOA
involved in cellular response to starvation IDA
IDA: Inferred from direct assay
14966024 GOA
involved in insulin receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
21852536 GOA
involved in negative regulation of anoikis IMP
IMP: Inferred from mutant phenotype
21852536 GOA
involved in reactive oxygen species metabolic process IMP
IMP: Inferred from mutant phenotype
21852536 GOA
involved in regulation of acetyl-CoA biosynthetic process from pyruvate IMP
IMP: Inferred from mutant phenotype
21852536 GOA
involved in regulation of fatty acid biosynthetic process IMP
IMP: Inferred from mutant phenotype
21852536 GOA
involved in regulation of glucose metabolic process IMP
IMP: Inferred from mutant phenotype
21852536 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PDK4 Protein Structure

BCDHK_Adom3

BCDHK_Adom3: Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase (34 - 195)

HATPase_c

HATPase_c: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (244 - 365)

  • 0
  • 100
  • 200
  • 300
  • 411 a.a.
Protein Preferred Names Protein Names

pyruvate dehydrogenase kinase, isozyme 4

  • [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial

PDK4 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
PDK4 Q16654 PLEKHF2 Homo sapiens Q9H8W4
Y2H Prey Pooling
32296183
Intra
PDK4 Q16654 PLEKHF2 Homo sapiens Q9H8W4
Validated Y2H
32296183
Intra
PDK4 Q16654 PLEKHF2 Homo sapiens Q9H8W4
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

PDK4 Antibodies

Cat. No. Product Name Application Reactivity
HY-P89698 PDK4 Antibody (YA9042) WB, ICC/IF, IF-Tissue, IP, ELISA human

Related Diseases

Diseases Alias
Type 2 Diabetes Mellitus

  • Insulin Resistance

  • NIDDM

  • Type 2 Diabetes

  • Diabetes Mellitus, Non-Insulin-Dependent

  • T2D

  • Noninsulin-Dependent Diabetes Mellitus

  • Diabetes Mellitus, Type Ii

  • Maturity-Onset Diabetes

  • Insulin Resistance, Severe, Digenic

  • Diabetes Mellitus, Type 2

  • Diabetes Mellitus, Noninsulin-Dependent

  • Diabetes Mellitus, Noninsulin-Dependent, Association With

  • Diabetes Mellitus, Noninsulin-Dependent, Late Onset

  • Hypertension, Insulin Resistance-Related, Susceptibility To

  • Insulin Resistance, Susceptibility To

  • Non-Insulin-Dependent Diabetes Mellitus

  • Type Ii Diabetes Mellitus

  • Adult-Onset Diabetes Mellitus

  • Maturity-Onset Diabetes Mellitus

  • Diabetes Mellitus Type 2

  • Type Ii Diabetes

  • Type 2 Diabetes Mellitus, Susceptibility To

  • Diabetes, Type 2

  • Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To

  • Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To

  • Diabetes Mellitus, Type 2, Susceptibility To

  • Diabetes Mellitus, Noninsulin-Dependent, 2

  • Diabetes Mellitus, Type Ii, Susceptibility To

  • Hypertension, Insulin Resistance-Related

  • Adult-Onset Diabetes

  • Aodm

  • Diabetes Mellitus, Adult-Onset

  • Diabetes Mellitus Type Ii

  • Diabetes Mellitus Type 2, Susceptibility To

  • Diabetes, Type Ii, Susceptibility To

  • Diabetes Type 2

  • Diabetes Mellitus

  • Adult Onset Diabetes

  • Maturity Onset Diabetes

  • Nonketotic Diabetes

  • Non-Insulin Dependent Diabetes Mellitus

  • T2dm - [Type 2 Diabetes Mellitus]

  • Niddm - [Non Insulin Dependent Diabetes Mellitus]

  • Dm2

  • Dm Type Ii

  • Diabetic Type 2

  • Insulin Requiring Type 2 Diabetes

  • Noninsulin Dependent Diabetes

  • Non-Insulin-Dependent Diabetes Mellitus Without Complications

  • Diabetes Due To Insulin Secretory Defect

  • Diabetes Mellitus Due To Insulin Secretory Defect

  • Non-Insulin-Dependent Diabetes Of The Young

  • Senile Diabetes

  • Nonketotic Hyperglycaemia

  • Stable Diabetes
Rhabdomyosarcoma
Diabetes Mellitus

  • Diabetes
Body Mass Index Quantitative Trait Locus 11

  • OBESITY

  • Obesity, Susceptibility To

  • Leanness, Inherited

  • Obesity, Susceptibility To, Bmiq11

  • Obesity, Mild, Early-Onset

  • Obesity, Association With

  • Obesity, Early-Onset, Susceptibility To

  • Obesity, Severe

  • Obesity, Severe, And Type Ii Diabetes

  • Obesity, Late-Onset

  • Obesity , Susceptibility To

  • BMIQ11

  • Obesity Bmiq11

  • Obesity, Early-Onset

  • Simple Obesity Nos

  • Excess Fat

  • Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified

  • Adiposis
Dilated Cardiomyopathy

  • Familial Dilated Cardiomyopathy

  • Primary Dilated Cardiomyopathy

  • Idiopathic Dilated Cardiomyopathy

  • Congestive Cardiomyopathy

  • Idiopathic Dilation Cardiomyopathy

  • Primary Familial Dilated Cardiomyopathy

  • Cardiomyopathy, Dilated

  • DCM

  • Cardiomyopathy, Familial Dilated

  • Dilated Cardiomyopathy, Familial

  • Hypokinetic Dilated Cardiomyopathy, Familial

  • Familial Idiopathic Cardiomyopathy

  • Fdc

  • Cardiomyopathy, Familial Idiopathic

  • Idiopathic Cardiomegaly

  • Dilated Congestive Cardiomyopathy

  • Chronic Dilated Cardiomyopathy

  • Ccm - [Congestive Cardiomyopathy]

  • Cocm - [Congestive Cardiomyopathy]

  • Dcm - [Dilated Cardiomyopathy]

  • Dilated-Hypokinetic Cardiomyopathy

  • Congestive Idiopathic Cardiomyopathy

  • Primary Idiopathic Dilated Cardiomyopathy
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (14)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-135954A PDK4-IN-1 hydrochloride 99.72% Unkown
HY-12492 VER-246608 Inhibitor 99.10% Unkown
HY-121744 PS10 Inhibitor 98.51% Unkown
HY-135954 PDK4-IN-1 99.34% Unkown
HY-114702 M77976 Inhibitor 99.44% Unkown
HY-139185 PROTAC ERRα Degrader-3 Inhibitor 98.82% Unkown
HY-134908 DHNA Inhibitor 99.65% Unkown
HY-RS10278 PDK4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-156109 PDK-IN-2 / Unkown
HY-157538 PDK4-IN-2 Inhibitor / Unkown
HY-183318 PPARα/δ agonist 4 Agonist / Unkown
HY-116257 GSK-7227 Agonist / Unkown
HY-RS16617 Pdk4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23052 Pdk4 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus PDK4 VGNC VGNC:32706
Felis catus PDK4 VGNC VGNC:68777
Macaca mulatta PDK4 VGNC VGNC:75935
Mus musculus PDK4 MGD MGI:1351481
Rattus norvegicus PDK4 RGD RGD:69061
Canis familiaris PDK4 VGNC VGNC:44383
Others PDK4 NCBI