UBASH3A - ubiquitin associated and SH3 domain containing A Gene

Also Known as TULA; CLIP4; STS-2; TULA-1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 53347

About UBASH3A

Cytogenetic location: 21q22.3 Genomic coordinates (GRCh38): 21:42,403,902-42,447,684 (from NCBI)

This gene has 9 transcripts (splice variants), 132 orthologues and 1 paralogue. Biased expression in lymph node (RPKM 3.3), appendix (RPKM 1.9) and 12 other tissues.

Summary

This gene encodes one of two family members belonging to the T-cell ubiquitin ligand (TULA) family. Both family members can negatively regulate T-cell signaling. This family member can facilitate growth factor withdrawal-induced Apoptosis in T cells, which may occur via its interaction with AIF, an apoptosis-inducing factor. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Aug 2011]

UBASH3A Products (3)

mRNA Protein Name
NM_001001895.3 NP_001001895.1 ubiquitin-associated and SH3 domain-containing protein A isoform 2
NM_001243467.2 NP_001230396.1 ubiquitin-associated and SH3 domain-containing protein A isoform 3
NM_018961.4 NP_061834.1 ubiquitin-associated and SH3 domain-containing protein A isoform 1

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
21516116 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

UBASH3A Protein Structure

SH3_9

SH3_9: Variant SH3 domain (283 - 336)

His_Phos_1

His_Phos_1: Histidine phosphatase superfamily (branch 1) (398 - 595)

  • 0
  • 200
  • 400
  • 600
  • 661 a.a.
Protein Preferred Names Protein Names

ubiquitin-associated and SH3 domain-containing protein A

  • T-cell ubiquitin ligand 1

UBASH3A Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
UBASH3A P57075 KRT40 Homo sapiens Q6A162
Validated Y2H
25416956
Intra
UBASH3A P57075 KRT40 Homo sapiens Q6A162
Y2H Array
25416956
Intra
UBASH3A P57075 KCNE1 Homo sapiens Q6FHJ6
Validated Y2H
25416956
Intra
UBASH3A P57075 REL Homo sapiens Q04864
Y2H Array
25416956
Intra
UBASH3A P57075 CBS Homo sapiens P35520
Y2H Array
31515488
Intra
UBASH3A P57075 CBS Homo sapiens P35520
Y2H Prey Pooling
25416956
Intra
UBASH3A P57075 SPRY2 Homo sapiens O43597
Validated Y2H
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant UBASH3A Proteins

Cat. No. Product Name Accession Purity
HY-P76687 UBASH3A Protein, Human (His) P57075-2 (A353-N623) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Celiac Disease 1

  • Celiac Disease

  • Coeliac Disease

  • Celiac Sprue

  • Celiac Disease, Susceptibility To

  • Gluten-Sensitive Enteropathy

  • Nontropical Sprue

  • Sprue

  • CELIAC1

  • Celiac Disease, Susceptibility To, 1

  • Celiac Sprue 1

  • Celiac Sprue, Susceptibility To, 1

  • Gluten-Sensitive Enteropathy 1

  • Gluten-Sensitive Enteropathy, Susceptibility To, 1

  • Idiopathic Steatorrhea

  • Cœliac Disease

  • Gluten Intolerance

  • Gluten-Induced Enteropathy

  • Gluten Enteropathy

  • Celiac Disease, Susceptibility To, Type 1

  • Childhood Celiac Disease

  • Coeliac Rickets

  • Gee Disease

  • Gee-Herter Disease

  • Heubner-Herter Disease

  • Idiopathic Steatorrhoea

  • Thaysen'S Disease

  • Herter Gee Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15331 UBASH3A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20660 Ubash3a Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27171 Ubash3a Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus UBASH3A VGNC VGNC:66755
Mus musculus UBASH3A MGD MGI:1926074
Canis familiaris UBASH3A VGNC VGNC:53047
Bos taurus UBASH3A VGNC VGNC:36574
Macaca mulatta UBASH3A VGNC VGNC:78687
Rattus norvegicus UBASH3A RGD RGD:1310305
Others UBASH3A NCBI