PLIN1 - perilipin 1 Gene

Also Known as PERI; PLIN; FPLD4

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 5346

About PLIN1

Cytogenetic location: 15q26.1 Genomic coordinates (GRCh38): 15:89,664,367-89,679,367 (from NCBI)

This gene has 4 transcripts (splice variants), 158 orthologues, 4 paralogues and is associated with 2 phenotypes. Restricted expression toward fat (RPKM 771.2).

Summary

The protein encoded by this gene coats lipid storage droplets in adipocytes, thereby protecting them until they can be broken down by hormone-sensitive Lipase. The encoded protein is the major cAMP-dependent protein kinase substrate in adipocytes and, when unphosphorylated, may play a role in the inhibition of lipolysis. Alternatively spliced transcript variants varying in the 5' UTR, but encoding the same protein, have been found for this gene. [provided by RefSeq, Feb 2009]

PLIN1 Products (2)

mRNA	Protein	Name
NM_001145311.2	NP_001138783.1	perilipin-1
NM_002666.5	NP_002657.3	perilipin-1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	27832861	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PLIN1 Protein Structure

Perilipin

0
100
200
300
400
522 a.a.

Protein Preferred Names	Protein Names
perilipin-1	lipid droplet-associated protein

PLIN1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	PLIN1	O60240	AQP7	Homo sapiens	O14520	Confocal	27832861
Intra	PLIN1	O60240	AQP7	Homo sapiens	O14520	PLA	27832861
Intra	PLIN1	O60240	AQP7	Homo sapiens	O14520	Far-WB	27832861

Cross: Cross-species interaction Intra: Intraspecies interaction

PLIN1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82793	Perilipin-1 Antibody (YA2538)	WB, ICC/IF	Human, Mouse
HY-P86371	Perilipin-1 Antibody (YA6063)	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Lipodystrophy, Familial Partial, Type 4	FPLD4 Plin1-Related Familial Partial Lipodystrophy Familial Partial Lipodystrophy Type 4 Familial Partial Lipodystrophy Associated With Plin1 Mutations Plin1-Related Fpld Lipodystrophy, Familial Partial, Associated With Plin1 Mutations Lipodystrophy, Familial Partial, 4
Familial Partial Lipodystrophy	Lipodystrophy, Familial Partial Fpld Kobberling-Dunnigan Syndrome Dunnigan Syndrome Koberling-Dunnigan Syndrome Dunnigan-Kobberling Syndrome Fpl Familial Partial Lipodystrophy, Type 2
Chanarin-Dorfman Syndrome	Neutral Lipid Storage Disease CDS Neutral Lipid Storage Disease With Ichthyosis Triglyceride Storage Disease With Impaired Long-Chain Fatty Acid Oxidation Triglyceride Storage Disease With Ichthyosis Nlsdi Ichthyotic Neutral Lipid Storage Disease Dorfman-Chanarin Syndrome Dcs Chanarin-Dorfman Disease Ichthyosiform Erythroderma With Leukocyte Vacuolation Lipidosis With Triglyceride Storage Disease Disorder Of Cornification 12 Dorfman Chanarin Syndrome Neutral Lipid Storage Disease With Ichthyotic Dorfman-Chanarin Disease
Lipodystrophy, Familial Partial, Type 5	FPLD5 Cidec-Related Familial Partial Lipodystrophy Familial Partial Lipodystrophy Type 5 Cidec-Related Fpld Familial Partial Lipodystrophy Associated With Cidec Mutations Lipodystrophy, Familial Partial, Associated With Cidec Mutations Lipodystrophy, Familial Partial, 5
Lipodystrophy, Familial Partial, Type 2	FPLD2 Lipoatrophic Diabetes Familial Partial Lipodystrophy Type 2 Familial Partial Lipodystrophy, Dunnigan Type Fpl2 Lipoatrophic Diabetes Mellitus Lipodystrophy, Familial Partial, Dunnigan Type Lipodystrophy, Familial, Of Limbs And Lower Trunk Lipodystrophy, Reverse Partial Familial Partial Lipodystrophy Dunnigan Type Dunnigan Syndrome Familial Lipodystrophy Of Limbs And Lower Trunk Reverse Partial Lipodystrophy Lipodystrophy, Familial Partial, 2 Generalized Lipoatrophy Associated With Diabetes, Hepatic Steatosis, Hypertrophic Cardiomyopathy And Leukomelanodermic Papules Lipodystrophy Familial Of Limbs And Lower Trunk Lipodystrophy Reverse Partial Diabetes Mellitus, Lipoatrophic Familial Partial Lipodystrophy, Type 2 Familial Generalized Lipodystrophy
Diabetes Mellitus	Diabetes
Adiposis Dolorosa	Dercum Disease Dercum'S Disease Lipomatosis Dolorosa Adiposalgia Adipose Tissue Rheumatism Anders Syndrome Dercum-Vitaut Syndrome Morbus Dercum
Acquired Generalized Lipodystrophy	Lawrence Syndrome Acquired Lipoatrophic Diabetes Lawrence-Seip Syndrome Familial Generalized Lipodystrophy
Body Mass Index Quantitative Trait Locus 11	OBESITY Obesity, Susceptibility To Leanness, Inherited Obesity, Susceptibility To, Bmiq11 Obesity, Mild, Early-Onset Obesity, Association With Obesity, Early-Onset, Susceptibility To Obesity, Severe Obesity, Severe, And Type Ii Diabetes Obesity, Late-Onset Obesity , Susceptibility To BMIQ11 Obesity Bmiq11 Obesity, Early-Onset Simple Obesity Nos Excess Fat Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified Adiposis
Complete Generalized Lipodystrophy
Lipodystrophy, Familial Partial, Type 3	FPLD3 Pparg-Related Familial Partial Lipodystrophy Familial Partial Lipodystrophy Type 3 Familial Partial Lipodystrophy Associated With Pparg Mutations Pparg-Related Fpld Lipodystrophy, Familial Partial, Associated With Pparg Mutations Insulin Resistance, Severe, Digenic Lipodystrophy, Familial Partial, 3 Familial Partial Lipodystrophy, Type 3
Lipodystrophy, Familial Partial, Type 6	FPLD6 Lipe-Related Familial Partial Lipodystrophy Familial Partial Lipodystrophy Type 6 Lipe-Related Fpld Lipodystrophy, Familial Partial, Associated With Lipe Mutations Familial Partial Lipodystrophy Associated With Lipe Mutations Lipodystrophy, Familial Partial, 6
Lipodystrophy, Congenital Generalized, Type 2	Congenital Generalized Lipodystrophy Type 2 CGL2 Berardinelli-Seip Congenital Lipodystrophy Type 2 Berardinelli-Seip Syndrome Brunzell Syndrome Bscl2-Related Total Lipodystrophy And Acromegaloid Gigantism Berardinelli-Seip Congenital Lipodystrophy, Type 2 Seip Syndrome Berardinelli Syndrome Lipodystrophy, Total, And Acromegaloid Gigantism Lipoatrophic Diabetes, Congenital Lipodystrophy, Berardinelli-Seip Congenital, Type 2 Brunzell Syndrome, Bscl2-Related Congenital Lipoatrophic Diabetes Congenital Generalized Lipodystrophy 2 Lipoatrophic Diabetes Lipodystrophy Berardinelli Type Familial Generalized Lipodystrophy Lipoatrophic Diabetes Mellitus Familial Partial Lipodystrophy, Type 2
Meibomian Cyst	Chalazion Meibomian Gland Lipogranuloma Tarsal Cyst
Congenital Generalized Lipodystrophy	Berardinelli-Seip Congenital Lipodystrophy Berardinelli-Seip Syndrome Brunzell Syndrome Bscl Generalized Lipodystrophy Lipodystrophy, Congenital Generalized Seip Syndrome Total Lipodystrophy Cgl Lipoatrophic Diabetes Lipodystrophy, Generalized, Congenital Familial Generalized Lipodystrophy Congenital Generalized Lipodystrophy Type 2 Lipoatrophic Diabetes Mellitus Familial Partial Lipodystrophy, Type 2
Type 2 Diabetes Mellitus	Insulin Resistance NIDDM Type 2 Diabetes Diabetes Mellitus, Non-Insulin-Dependent T2D Noninsulin-Dependent Diabetes Mellitus Diabetes Mellitus, Type Ii Maturity-Onset Diabetes Insulin Resistance, Severe, Digenic Diabetes Mellitus, Type 2 Diabetes Mellitus, Noninsulin-Dependent Diabetes Mellitus, Noninsulin-Dependent, Association With Diabetes Mellitus, Noninsulin-Dependent, Late Onset Hypertension, Insulin Resistance-Related, Susceptibility To Insulin Resistance, Susceptibility To Non-Insulin-Dependent Diabetes Mellitus Type Ii Diabetes Mellitus Adult-Onset Diabetes Mellitus Maturity-Onset Diabetes Mellitus Diabetes Mellitus Type 2 Type Ii Diabetes Type 2 Diabetes Mellitus, Susceptibility To Diabetes, Type 2 Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To Diabetes Mellitus, Type 2, Susceptibility To Diabetes Mellitus, Noninsulin-Dependent, 2 Diabetes Mellitus, Type Ii, Susceptibility To Hypertension, Insulin Resistance-Related Adult-Onset Diabetes Aodm Diabetes Mellitus, Adult-Onset Diabetes Mellitus Type Ii Diabetes Mellitus Type 2, Susceptibility To Diabetes, Type Ii, Susceptibility To Diabetes Type 2 Diabetes Mellitus Adult Onset Diabetes Maturity Onset Diabetes Nonketotic Diabetes Non-Insulin Dependent Diabetes Mellitus T2dm - [Type 2 Diabetes Mellitus] Niddm - [Non Insulin Dependent Diabetes Mellitus] Dm2 Dm Type Ii Diabetic Type 2 Insulin Requiring Type 2 Diabetes Noninsulin Dependent Diabetes Non-Insulin-Dependent Diabetes Mellitus Without Complications Diabetes Due To Insulin Secretory Defect Diabetes Mellitus Due To Insulin Secretory Defect Non-Insulin-Dependent Diabetes Of The Young Senile Diabetes Nonketotic Hyperglycaemia Stable Diabetes

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-111952	SR-4995		98.26%	Unkown
HY-111953	SR-4559		98.81%	Unkown
HY-RS10706	PLIN1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21693	Plin1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28211	Plin1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	PLIN1	VGNC	VGNC:44690
Bos taurus	PLIN1	VGNC	VGNC:33029
Felis catus	PLIN1	VGNC	VGNC:104576
Macaca mulatta	PLIN1	VGNC	VGNC:76175
Mus musculus	PLIN1	MGD	MGI:1890505
Rattus norvegicus	PLIN1	RGD	RGD:3351
Others	PLIN1	NCBI