FBXL12 - F-box and leucine rich repeat protein 12 Gene

Also Known as Fbl12

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 54850

About FBXL12

Cytogenetic location: 19p13.2 Genomic coordinates (GRCh38): 19:9,810,270-9,819,079 (from NCBI)

This gene has 13 transcripts (splice variants) and 186 orthologues. Ubiquitous expression in placenta (RPKM 6.0), bone marrow (RPKM 5.9) and 25 other tissues.

Summary

Members of the F-box protein family, such as FBXL12, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through Other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]

FBXL12 Products (8)

mRNA Protein Name
NM_001316936.2 NP_001303865.1 F-box/LRR-repeat protein 12 isoform b
NM_001316937.2 NP_001303866.1 F-box/LRR-repeat protein 12 isoform c
NM_001316938.2 NP_001303867.1 F-box/LRR-repeat protein 12 isoform c
NM_001316939.2 NP_001303868.1 F-box/LRR-repeat protein 12 isoform c
NM_001316940.2 NP_001303869.1 F-box/LRR-repeat protein 12 isoform c
NM_001316941.2 NP_001303870.1 F-box/LRR-repeat protein 12 isoform c
NM_001316942.2 NP_001303871.1 F-box/LRR-repeat protein 12 isoform c
NM_017703.3 NP_060173.1 F-box/LRR-repeat protein 12 isoform a

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
18660753 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FBXL12 Protein Structure

F-box-like

F-box-like: F-box-like (6 - 49)

  • 0
  • 100
  • 200
  • 300
  • 326 a.a.
Protein Preferred Names Protein Names

F-box/LRR-repeat protein 12

  • F-box protein FBL12

FBXL12 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
FBXL12 Q9NXK8 DOCK8 Homo sapiens Q8NF50-2
Y2H Array
25416956
Intra
FBXL12 Q9NXK8 SKP1 Homo sapiens P63208
Pull Down
18660753
Intra
FBXL12 Q9NXK8 GEMIN4 Homo sapiens P57678
Y2H Array
32296183
Intra
FBXL12 Q9NXK8 GEMIN4 Homo sapiens P57678
Y2H Prey Pooling
32296183
Intra
FBXL12 Q9NXK8 CDKN1C Homo sapiens P49918
Anti Bait CoIP
18660753
Intra
FBXL12 Q9NXK8 CDKN1C Homo sapiens P49918
Anti Tag CoIP
18660753
Intra
FBXL12 Q9NXK8 LNX1 Homo sapiens Q8TBB1
Validated Y2H
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04783 FBXL12 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus FBXL12 VGNC VGNC:102582
Bos taurus FBXL12 VGNC VGNC:52772
Canis familiaris FBXL12 VGNC VGNC:54945
Macaca mulatta FBXL12 VGNC VGNC:72502
Rattus norvegicus FBXL12 RGD RGD:1305528
Mus musculus FBXL12 MGD MGI:1354738
Others FBXL12 NCBI