TYW2 - tRNA wybutosine-synthesizing protein 2 Gene

Also Known as TRM12; TRMT12

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 55039

Summary

Wybutosine (yW) is a hypermodified Guanosine at the 3-prime position adjacent to the anticodon of phenylalanine tRNA that stabilizes codon-anticodon interactions during decoding on the ribosome. TRMT12 is the human homolog of a yeast gene essential for yW synthesis (Noma and Suzuki, 2006).[supplied by OMIM, Mar 2008]

TYW2 Products (1)

mRNA Protein Name
NM_017956.4 NP_060426.2 tRNA wybutosine-synthesizing protein 2 homolog

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TYW2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
TRMT12 Q53H54 PRDM6 Homo sapiens Q9NQX0
Y2H Prey Pooling
32296183
Intra
TRMT12 Q53H54 PRDM6 Homo sapiens Q9NQX0
Validated Y2H
32296183
Intra
TRMT12 Q53H54 PRDM6 Homo sapiens Q9NQX0
Y2H Array
32296183
Intra
TRMT12 Q53H54 LNX1 Homo sapiens Q8TBB1
Y2H Array
25416956
Intra
TRMT12 Q53H54 LNX1 Homo sapiens Q8TBB1
Y2H Prey Pooling
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction