TMEM33 - transmembrane protein 33 Gene

Also Known as Pom33; SHINC3; SHINC-3; 1600019D15Rik

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 55161

About TMEM33

Cytogenetic location: 4p13 Genomic coordinates (GRCh38): 4:41,935,137-41,960,803 (from NCBI)

This gene has 8 transcripts (splice variants) and 209 orthologues. Ubiquitous expression in brain (RPKM 8.6), thyroid (RPKM 8.4) and 25 other tissues.

Summary

Involved in positive regulation of endoplasmic reticulum unfolded protein response; regulation of endoplasmic reticulum tubular network organization; and response to endoplasmic reticulum stress. Located in endoplasmic reticulum membrane; melanosome; and nuclear envelope. Is integral component of endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Apr 2022]

TMEM33 Products (1)

mRNA Protein Name
NM_018126.3 NP_060596.2 transmembrane protein 33

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
17215244 GOA
Biological Process GO Annotation Evidence References Source
involved in positive regulation of IRE1-mediated unfolded protein response IDA
IDA: Inferred from direct assay
26268696 GOA
involved in positive regulation of PERK-mediated unfolded protein response IDA
IDA: Inferred from direct assay
26268696 GOA
involved in regulation of endoplasmic reticulum tubular network organization IDA
IDA: Inferred from direct assay
25612671 GOA
involved in response to endoplasmic reticulum stress IDA
IDA: Inferred from direct assay
26268696 GOA
Cellular Component GO Annotation Evidence References Source
located in endoplasmic reticulum IDA
IDA: Inferred from direct assay
25612671 GOA
located in endoplasmic reticulum membrane IDA
IDA: Inferred from direct assay
25612671 GOA
located in melanosome IDA
IDA: Inferred from direct assay
17081065 GOA
located in nuclear envelope IDA
IDA: Inferred from direct assay
25612671 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TMEM33 Protein Structure

UPF0121

UPF0121: Uncharacterised protein family (UPF0121) (3 - 246)

  • 0
  • 100
  • 200
  • 247 a.a.
Protein Preferred Names Protein Names

transmembrane protein 33

TMEM33 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
TMEM33 P57088 MTNR1A Homo sapiens P48039
Ub Reconstruction
28298427
Intra
TMEM33 P57088 q96fb2_human Homo sapiens Q96FB2
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Breast Cancer

  • Breast Carcinoma

  • Male Breast Cancer

  • Breast Cancer, Familial

  • Malignant Neoplasm Of Breast

  • Breast Cancer, Susceptibility To

  • Breast Cancer, Early-Onset

  • Malignant Tumor Of Breast

  • Carcinoma Of Male Breast

  • Breast Cancer, Invasive Ductal

  • Breast Cancer, Protection Against

  • Breast Cancer, Somatic

  • Breast Cancer, Male

  • Breast Cancer, Lobular, Somatic

  • Breast Tumor

  • Mammary Cancer

  • Mammary Tumor

  • Malignant Neoplasm Of Male Breast

  • Mammary Carcinoma

  • Male Breast Carcinoma

  • Familial Cancer Of Breast

  • Invasive Ductal Breast Carcinoma

  • Breast Cancer Susceptibility

  • Breast Cancer, Male, Susceptibility To

  • Breast Cancer, Early-Onset, Susceptibility To

  • Malignant Tumor Of The Breast

  • Mammary Neoplasm

  • Primary Breast Cancer

  • Neoplasm Of Male Breast

  • Carcinoma Of Breast

  • Breast Cancer In Men

  • Familial Breast Cancer

  • Cancer Of Breast

  • BC

  • Breast Cancer Familial

  • Breast Cancer Familial Male

  • Breast Cancer, Familial Male

  • Breast Male Carcinoma

  • Breast Neoplasms

  • Breast Neoplasms, Male

  • Mammary Tumors

  • Mammary Carcinomas

  • Cancer, Breast

  • Cancer, Breast, Susceptibility

  • Invasive Breast Ductal Carcinoma

  • Breast Neoplasm

  • Susceptibility To Breast Cancer

  • Mammary Neoplasms

  • Animal Mammary Neoplasms

  • Primary Malignant Neoplasm Of Breast

  • Infiltrating Ductal Carcinoma Of Breast

  • Infiltrating Duct Carcinoma Of Unspecified Site

  • Infiltrating Ductular Carcinoma Of Unspecified Site

  • Invasive Breast Carcinoma Of No Special Type

  • Microinvasive Carcinoma Of Breast

  • Carcinoma With Apocrine Differentiation
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14717 TMEM33 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus TMEM33 RGD RGD:708371
Macaca mulatta TMEM33 VGNC VGNC:79511
Felis catus TMEM33 VGNC VGNC:107476
Canis familiaris TMEM33 VGNC VGNC:47571
Bos taurus TMEM33 VGNC VGNC:36076
Mus musculus TMEM33 MGD MGI:1915128
Others TMEM33 NCBI