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  2. MTNR1A - melatonin receptor 1A Gene

MTNR1A - melatonin receptor 1A Gene

Homo sapiens

Also known as MT1; MEL-1A-R

Gene ID: 4543 | Gene type: protein coding

About MTNR1A

Cytogenetic location: 4q35.2 Genomic coordinates (GRCh38): 4:186,533,655-186,555,567 (from NCBI)

This gene has 2 transcripts (splice variants), 185 orthologues and 33 paralogues. Biased expression in kidney (RPKM 1.1), testis (RPKM 0.6) and 8 other tissues.

Summary

This gene encodes one of two high affinity forms of a receptor for melatonin, the primary hormone secreted by the pineal gland. This receptor is a G-protein coupled, 7-transmembrane receptor that is responsible for melatonin effects on mammalian circadian rhythm and reproductive alterations affected by day length. The receptor is an integral membrane protein that is readily detectable and localized to two specific regions of the brain. The hypothalamic suprachiasmatic nucleus appears to be involved in circadian rhythm while the hypophysial pars tuberalis may be responsible for the reproductive effects of melatonin. [provided by RefSeq, Jul 2008]

MTNR1A Products(2)

mRNA Protein Name
NM_005958.4 NP_005949.1 melatonin receptor type 1A
XM_011532002.4 XP_011530304.1 melatonin receptor type 1A isoform X1

MTNR1A Protein Structure

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (44 - 295)

  • 0
  • 100
  • 200
  • 300
  • 350 a.a.
Protein Preferred Names Protein Names

melatonin receptor type 1A

mel1a receptor

Related Diseases

Diseases Alias
Delayed Sleep Phase Disorder

Delayed Sleep Phase Syndrome

Delayed Sleep Phase Syndrome, Susceptibility To

DSPD

Delayed Sleep Phase Disorder, Susceptibility To

DSPS

Sleep Phase, Delayed, Disorder

Sleep Phase Syndrome, Delayed, Susceptibility To

Major Depressive Disorder

Seasonal Affective Disorder

Unipolar Depression

Depression

MDD

Depressive Disorder

Unipolar Depression, Susceptibility To

Major Depressive Disorder 1

Major Depressive Disorder, Response To Citalopram Therapy In

Major Depressive Disorder 2

Winter Depression

Single Major Depressive Episode

Sad

Clinical Depression

Major Depression

Depressive Syndrome

Major Depressive Disorder And Accelerated Response To Antidepressant Drug Treatment

Seasonal Affective Disorder, Susceptibility To

Recurrent Major Depression

Affective Disorder, Seasonal

Depression In A Seasonal Pattern

Depression

Seasonal

Major Depressive Disorder With A Seasonal Pattern

Seasonal Depression

Seasonal Mood Disorder

Mental Depression

Recurrent Major Depressive Episodes

Deafness, Autosomal Dominant 24

DFNA24

Autosomal Dominant Nonsyndromic Deafness 24

Autosomal Dominant Deafness 24

Nephrolithiasis

Kidney Stones

Stone - Kidney/Ureter

Kidney Calculi

Alzheimer Disease, Familial, 1

Alzheimer Disease

Alzheimer'S Disease

Presenile And Senile Dementia

AD1

Alzheimer Disease, Susceptibility To

Alzheimer Disease, Late-Onset, Susceptibility To

Alzheimer Disease 1, Familial

AD

Familial Alzheimer Disease

Alzheimer Disease, Late-Onset

Alzheimers Dementia

Alzheimer Dementia

Alzheimer Sclerosis

Alzheimer Syndrome

Alzheimer-Type Dementia

Dat

Primary Senile Degenerative Dementia

Sdat

Alzheimer Disease 1

Autosomal Dominant Alzheimer Disease

Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy

Late Onset Alzheimer Disease

Alzheimers Disease

Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy

Late-Onset Alzheimers Disease

Alzheimer'S Disease Pathway Kegg

Dementia Due To Alzheimer'S Disease

Alzheimer Disease Type 1

Alzheimers

Scoliosis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Bos taurus MTNR1A VGNC VGNC:31746
Canis familiaris MTNR1A VGNC VGNC:110519
Mus musculus MTNR1A MGD MGI:102967
Rattus norvegicus MTNR1A RGD RGD:620797
Macaca mulatta MTNR1A VGNC VGNC:81477
Felis catus MTNR1A VGNC VGNC:78528