CCDC25 - coiled-coil domain containing 25 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 55246

About CCDC25

Cytogenetic location: 8p21.1 Genomic coordinates (GRCh38): 8:27,733,316-27,772,640 (from NCBI)

This gene has 11 transcripts (splice variants) and 205 orthologues. Ubiquitous expression in duodenum (RPKM 17.8), small intestine (RPKM 15.9) and 25 other tissues.

Summary

Enables DNA binding activity. Involved in positive regulation of cell motility. Located in endomembrane system. Is integral component of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

CCDC25 Products (4)

mRNA Protein Name
NM_001304529.2 NP_001291458.1 coiled-coil domain-containing protein 25 isoform 2
NM_001304530.2 NP_001291459.1 coiled-coil domain-containing protein 25 isoform 3
NM_001304532.2 NP_001291461.1 coiled-coil domain-containing protein 25 isoform 4
NM_018246.3 NP_060716.2 coiled-coil domain-containing protein 25 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA binding IDA
IDA: Inferred from direct assay
32528174 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
Biological Process GO Annotation Evidence References Source
involved in positive regulation of cell motility IDA
IDA: Inferred from direct assay
32528174 GOA
Cellular Component GO Annotation Evidence References Source
located in endomembrane system IDA
IDA: Inferred from direct assay
32528174 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
32528174 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CCDC25 Protein Structure

DUF814

DUF814: Domain of unknown function (DUF814) (11 - 100)

  • 0
  • 100
  • 208 a.a.
Protein Preferred Names Protein Names

coiled-coil domain-containing protein 25

CCDC25 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
CCDC25 Q86WR0 FLJ13057 Homo sapiens Q53SE7
Validated Y2H
25416956
Intra
CCDC25 Q86WR0 TRIM23 Homo sapiens P36406
Validated Y2H
25416956
Intra
CCDC25 Q86WR0 TRIM23 Homo sapiens P36406
Y2H Array
25416956
Intra
CCDC25 Q86WR0 TRIM23 Homo sapiens P36406
Y2H Prey Pooling
25416956
Intra
CCDC25 Q86WR0 PLEKHF2 Homo sapiens Q9H8W4
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Chronic Cholangitis
Colorectal Cancer, Hereditary Nonpolyposis, Type 2

  • HNPCC2

  • Fcc2

  • Coca2

  • Hereditary Nonpolyposis Colorectal Cancer Type 2

  • Colon Cancer, Familial Nonpolyposis, Type 2

  • Familial Nonpolyposis Colon Cancer Type 2

  • Hereditary Non-Polyposis Colorectal Cancer 2

  • Cancer, Colorectal, Nonpolyposis, Hereditary, Type 2
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS02041 CCDC25 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19249 Ccdc25 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25738 Ccdc25 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus CCDC25 MGD MGI:1914429
Macaca mulatta CCDC25 VGNC VGNC:99468
Bos taurus CCDC25 VGNC VGNC:26888
Rattus norvegicus CCDC25 RGD RGD:1307689
Felis catus CCDC25 VGNC VGNC:78463
Others CCDC25 NCBI