PPY - pancreatic polypeptide Gene

Also Known as PP; PNP

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 5539

About PPY

Cytogenetic location: 17q21.31 Genomic coordinates (GRCh38): 17:43,940,804-43,944,215 (from NCBI)

This gene has 6 transcripts (splice variants), 90 orthologues and 2 paralogues. Biased expression in pancreas (RPKM 7.7), colon (RPKM 0.9) and 1 other tissue.

Summary

This gene encodes a member of the neuropeptide Y (NPY) family of peptides. The encoded 95 aa preproprotein is synthesized in the pancreatic islets of Langerhans and proteolytically processed to generate two peptide products. These products include the active pancreatic hormone of 36 aa and an icosapeptide of unknown function. This hormone acts as a regulator of pancreatic and gastrointestinal functions and may be important in the regulation of food intake. Plasma level of this hormone has been shown to be reduced in conditions associated with increased food intake and elevated in anorexia nervosa. In addition, infusion of this hormone in obese rodents has shown to decrease weight gain. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016]

PPY Products (2)

mRNA	Protein	Name
NM_001319209.2	NP_001306138.1	pancreatic prohormone isoform 2 precursor
NM_002722.5	NP_002713.1	pancreatic prohormone isoform 1 preproprotein

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables G protein-coupled receptor binding	IPI IPI: Inferred from physical interaction	7493937	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PPY Protein Structure

Hormone_3

0
95 a.a.

Protein Preferred Names	Protein Names
pancreatic prohormone	pancreatic polypeptide Y

PPY Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	PPY	P01298	CYSRT1	Homo sapiens	A8MQ03	Y2H Prey Pooling	32296183
Intra	PPY	P01298	CYSRT1	Homo sapiens	A8MQ03	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant PPY Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71062	PPY Protein, Human (HEK293, His)	P01298 (A30-R88)	≥ 95%, as determined by reducing SDS-PAGE.

PPY Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P87020	Pancreatic Polypeptide Antibody (YA6713)	IHC-P, IHC-F, IF-Tissue, mIHC	Mouse, Rat

Related Diseases

Diseases	Alias
Non-Functioning Pancreatic Endocrine Tumor	Non Functioning Pancreatic Endocrine Tumor Non-Functioning Epts Non-Functioning Endocrine Pancreatic Tumors
Auditory System Cancer	Ear Neoplasms
Middle Ear Adenocarcinoma	Adenocarcinoma Of Middle Ear Adenocarcinoma Of The Middle Ear
Middle Ear Adenoma	Adenoma Of Middle Ear Adenoma Of The Middle Ear
Auditory System Benign Neoplasm
Sensory Organ Benign Neoplasm
Pancreatic Somatostatinoma	Pancreatic Delta Cell Somatostatin Producing Neoplasm Pancreatic Somatostatin Cell Tumor
Pancreatic Cholera	Excessive Vasoactive Intestinal Peptide Secretion Pancreatic Wdha Syndrome Verner-Morrison Syndrome
Ceruminoma	Ceruminous Adenoma External Auditory Canal Ceruminous Adenoma
Jejunal Somatostatinoma	Jejunal Delta Cell Somatostatin Producing Tumor Somatosatinoma Of Jejunum Jejunal Somatostatin-Producing Neuroendocrine Tumor
Endocrine Pancreas Disease	Disorder Of Endocrine Pancreas
Duodenal Gastrinoma	Duodenal G-Cell Gastrin Producing Tumor Gastrinoma Of Duodenum Malignant Duodenal Gastrinoma Duodenal Gastrin-Producing Neuroendocrine Tumor
Autonomic Neuropathy	Diabetic Autonomic Neuropathy
Pancreatic Gastrinoma	Pancreatic G-Cell Tumor
Duodenal Somatostatinoma	Duodenal Delta Cell Somatostatin Producing Tumor Duodenal Somatostatin-Producing Neuroendocrine Tumor
Diabetic Autonomic Neuropathy	Diabetic Neuropathies
Multiple Endocrine Neoplasia	Men Multiple Endocrine Adenomatosis Multiple Endocrine Neoplasia Syndrome Adenomatosis, Familial Endocrine Endocrine Neoplasia, Multiple Familial Endocrine Adenomatosis Mea Multiple Endocrine Neoplasms Multiple Endocrine Neoplasia Type 1
Pancreatic Cystadenoma	Cystadenoma Of Pancreas
Middle Ear Carcinoma	Carcinoma Of Middle Ear Carcinoma Of The Middle Ear
Ceruminous Adenocarcinoma
Vipoma	Wdha Syndrome Pancreatic Cholera Pancreatic Vipoma Verner-Morrison Syndrome Diarrheogenic Islet Cell Tumor Vip-Secreting Tumor Malignant Vasoactive Intestinal Peptide-Secreting Tumor Vasoactive Intestinal Peptide-Secreting Tumor Vip- Secreting Tumor Vipoma, Malignant Vipoma Syndrome Watery Diarrhea Syndrome Watery Diarrhea, Hypokalemia, And Achlorhydria Syndrome Vasoactive Intestinal Peptide Tumor Vasoactive Intestinal Peptide-Producing Tumor Watery Diarrhea-Hypokalemia-Achlorhydria Syndrome Malignant Vipoma
Acute Hemorrhagic Pancreatitis	Pancreatitis, Acute Hemorrhagic
Mahvash Disease	Gcgr-Related Hyperglucagonemia MVAH Alpha-Cell Hyperplasia With Glucagonemia Nesidioblastosis, Alpha Cell Hyperplasia, Microglucagonoma, And Nonfunctioning Islet Cell Tumor Nesidioblastosis Alpha Cell Hyperplasia Microglucagonoma And Nonfunctioning Islet Cell Tumor
Somatostatinoma	Somatostatin Cell Neoplasm Somatostatin Cell Tumour Ampullary Somatostatinoma Carcinoid Somatostatinoma Malignant Islet Cell Tumor Somatomedin-Secreting Carcinoid Somatostatin-Secreting Pancreatic Neoplasm Pancreatic Somatostatinoma Pancreatic Endocrine Carcinoma
Islet Cell Tumor	Pancreatic Neuroendocrine Tumor Neuroendocrine Tumor Of Pancreas Pnet Pancreatic Net Pancreatic Endocrine Tumor Well-Differentiated Nen Of Pancreas Well-Differentiated Neuroendocrine Neoplasm Of Pancreas Well-Differentiated Pancreatic Nen Well-Differentiated Pancreatic Neuroendocrine Neoplasm Endocrine Pancreas Cancer Islet Cell Neoplasm Islet Cell Tumour Malignant Pancreatic Endocrine Tumor Malignant Pancreatic Endocrine Tumour Malignant Tumor Of Endocrine Pancreas Malignant Tumour Of Endocrine Pancreas Pancreatic Endocrine Neoplasm Pancreatic Neuroendocrine Neoplasm Adenoma, Islet Cell Well Differentiated Pancreatic Endocrine Tumor Malignant Neoplasm Of Endocrine Pancreas Pancreatic Endocrine Carcinoma
Hyperinsulinemic Hypoglycemia	Nesidioblastosis Islet Cell Hyperplasia Persistent Hyperinsulinemia Hypoglycemia Of Infancy Hyperinsulinemic Hypoglycaemia
Prader-Willi Syndrome	Prader-Labhart-Willi Syndrome PWS Willi-Prader Syndrome Prader-Willi Syndrome Due To Translocation Prader-Willi Syndrome Due To Imprinting Mutation Prader-Willi Syndrome Due To Maternal Uniparental Disomy Of Chromosome 15 Prader Willi Syndrome Upd(15)Mat
Pancreas, Annular	Annular Pancreas Pancreas Annulare Congenital Annular Pancreas
Pancreatic Endocrine Carcinoma	Carcinoma Of Endocrine Pancreas Islet Cell Carcinoma Malignant Neoplasm Of Islets Of Langerhans Pancreatic Neuroendocrine Carcinoma Carcinoma Islet Cell Carcinoma, Islet Cell
Functional Gastric Disease
Partington Syndrome	X-Linked Reticulate Pigmentary Disorder PRTS Partington X-Linked Mental Retardation Syndrome Mrxs1 Mrx36 Intellectual Developmental Disorder, X-Linked, Syndromic 1 Partington Disease Pdr Partington-Mulley Syndrome Russell-Silver Syndrome, X-Linked Mental Retardation, X-Linked, Syndromic 1 Mental Retardation, X-Linked, With Dystonic Movements, Ataxia, And Seizures Mental Retardation, X-Linked 36 X-Linked Reticulate Pigmentary Disorder With Systemic Manifestations X-Linked Russell-Silver Syndrome Intelectual Disability-Dystonic Movements-Ataxia-Seizures Syndrome Intellectual Disability, X-Linked, Syndromic 1 Intellectual Disability, X-Linked, With Dystonic Movements, Ataxia, And Seizures Partington X-Linked Intellectual Disability Syndrome X-Linked Intellectual Deficit-Dystonia-Dysarthria X-Linked Mental Retardation With Dystonic Movements, Ataxia, And Seizures Familial Cutaneous Amyloidosis X-Linked Cutaneous Amyloidosis Xlpdr X-Linked Intellectual Disability-Dystonia-Dysarthria Syndrome Pigmentary Disorder, Reticulate, With Systemic Manifestations
Gastrointestinal Neuroendocrine Tumor	Gastrointestinal Neuroendocrine Tumour Malignant Gastrointestinal Neuroendocrine Tumor Malignant Gastrointestinal Neuroendocrine Tumour Digestive System Neuroendocrine Neoplasm Digestive System Neuroendocrine Tumor
Space Motion Sickness
Autonomic Nervous System Disease	Autonomic Nervous System Dysfunction Autonomic Nervous System Disorders Autonomic Nervous System Disorder Autonomic Nervous System Diseases Abnormality Of The Autonomic Nervous System
Abnormality Of Glucagon Secretion	Glucagon Secretion Abnormality Abnormality Of Secretion Of Glucagon
Endometrial Small Cell Carcinoma
Pancreatic Agenesis	Partial Pancreatic Agenesis Congenital Pancreatic Agenesis Partial Agenesis Of The Pancreas Agenesis, Pancreatic Pancreatic Agenesis, Congenital
Leptin Deficiency Or Dysfunction	Morbid Obesity Obesity Due To Congenital Leptin Deficiency LEPD Congenital Leptin Deficiency Obesity, Morbid Obesity, Morbid, Due To Leptin Deficiency Severe Obesity Obesity, Morbid, Nonsyndromic 1 Leptin Deficiency Obesity, Severe, Due To Leptin Deficiency Leptin Morbid Obesity Due To Leptin Deficiency Obesity Morbid Leptin Dysfunction
Peptic Ulcer Disease	Peptic Ulcer Acute Peptic Ulcer With Hemorrhage Acute Peptic Ulcer With Hemorrhage And Perforation Acute Peptic Ulcer Without Hemorrhage And Without Perforation
Duodenum Cancer	Duodenal Cancer Duodenal Neoplasms Cancer Of Duodenum Duodenal Neoplasm Duodenal Carcinoma Cancer, Duodenal Malignant Neoplasm Of Duodenum
Multiple Endocrine Neoplasia, Type I	Multiple Endocrine Neoplasia Type 1 MEN1 Wermer Syndrome Multiple Endocrine Neoplasia 1 Multiple Endocrine Neoplasia, Type 1 Men I Endocrine Adenomatosis, Multiple Mea I Men Type I Wermer'S Syndrome Men1 Syndrome Multiple Endocrine Adenomatosis Endocrine Adenomatosis Multiple Men 1 Familial Multiple Endocrine Neoplasia Type I Neoplasia, Endocrine, Multiple, Type 1 Multiple Endocrine Neoplasia
Duodenum Disease	Duodenal Diseases Duodenal Disease Duodenum Disorder
Gastrointestinal System Benign Neoplasm
Esophageal Neuroendocrine Tumor	Esophageal Neuroendocrine Tumour Neuroendocrine Tumor Of Esophagus Neuroendocrine Tumour Of Oesophagus
Von Hippel-Lindau Syndrome	Von Hippel-Lindau Disease Vhl Vhl Syndrome VHLS Von Hippel-Lindau Syndrome, Modifier Of Hippel Lindau Syndrome Angiomatosis Retinae Cerebelloretinal Angiomatosis, Familial Hippel-Lindau Disease Familial Cerebelloretinal Angiomatosis Lindau Disease VHLD
Diabetes Mellitus	Diabetes
Maturity-Onset Diabetes Of The Young	MODY Maturity Onset Diabetes Mellitus In Young Mason-Type Diabetes Mason Type Diabetes Maturity Onset Diabetes Of The Young Mody Syndrome Diabetes Of The Young, Maturity-Onset

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (14)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-W007596	Tris(2-phenylpyridinato-C2,N)iridium(III)		99.76%	Unkown
HY-W034043	[Ir(dF(Me)ppy)2(dtbbpy)]PF6		/	Unkown
HY-W034053	Ir[p-F(Me)ppy]2(dtbbpy)PF6		/	Unkown
HY-W004048	Sodium 4-methylbenzenesulfonate		99.89%	Unkown
HY-W075731	(Ir[dF(F)ppy]2(dCF3))PF6		/	Unkown
HY-W072530	[Ir(ppy)2(bpy)]PF6		≥98.0%	Unkown
HY-W034041	Ir(p-F-ppy)3		98.0%	Unkown
HY-W035599	Ir[p-F(t-Bu)-ppy]3		98%	Unkown
HY-12083	PPY-A	Inhibitor	98.02%	Unkown
HY-W013430	4-Amino-3-hydroxynaphthalene-1-sulfonic acid		98.0%	Unkown
HY-171069	FFA2 agonist-1	Agonist	/	Unkown
HY-RS11042	PPY Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20684	Ppy Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27195	Ppy Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	PPY	MGD	MGI:97753
Macaca mulatta	PPY	VGNC	VGNC:76387
Felis catus	PPY	VGNC	VGNC:69026
Bos taurus	PPY	VGNC	VGNC:55864
Canis familiaris	PPY	VGNC	VGNC:44933
Rattus norvegicus	PPY	RGD	RGD:3385
Others	PPY	NCBI