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SRGN - serglycin Gene

Also Known as PPG; PRG; PRG1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 5552

About SRGN

Cytogenetic location: 10q22.1 Genomic coordinates (GRCh38): 10:69,087,603-69,104,811 (from NCBI)

This gene has 2 transcripts (splice variants) and 110 orthologues. Biased expression in bone marrow (RPKM 1650.2), appendix (RPKM 289.1) and 5 other tissues.

Summary

This gene encodes a protein best known as a hematopoietic cell granule proteoglycan. Proteoglycans stored in the secretory granules of many hematopoietic cells also contain a protease-resistant peptide core, which may be important for neutralizing hydrolytic Enzymes. This encoded protein was found to be associated with the macromolecular complex of granzymes and perforin, which may serve as a mediator of granule-mediated Apoptosis. Two transcript variants, only one of them protein-coding, have been found for this gene. [provided by RefSeq, Jul 2010]

SRGN Products (3)

mRNA	Protein	Name
NM_001321053.2	NP_001307982.1	serglycin isoform 1 precursor
NM_001321054.1	NP_001307983.1	serglycin isoform 2
NM_002727.4	NP_002718.2	serglycin isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	11911826	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in granzyme-mediated programmed cell death signaling pathway	IDA IDA: Inferred from direct assay	11911826	GOA
involved in negative regulation of bone mineralization	IDA IDA: Inferred from direct assay	16870619	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in Golgi apparatus	IDA IDA: Inferred from direct assay	15136585	GOA
located in extracellular space	IDA IDA: Inferred from direct assay	11154222	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SRGN Protein Structure

Serglycin

0
100
158 a.a.

Protein Preferred Names	Protein Names
serglycin	hematopoetic proteoglycan core peptide

SRGN Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	SRGN	P10124	UBQLN1	Homo sapiens	Q9UMX0-2	Y2H Prey Pooling	25416956
Intra	SRGN	P10124	GZMB	Homo sapiens	P10144	GMS	11911826
Intra	SRGN	P10124	SGTA	Homo sapiens	O43765	Y2H Pooling	16189514
Intra	SRGN	P10124	SGTA	Homo sapiens	O43765	Y2H Prey Pooling	32296183
Intra	SRGN	P10124	SGTA	Homo sapiens	O43765	Y2H Array	25416956
Intra	SRGN	P10124	SGTA	Homo sapiens	O43765	Y2H Array	32296183
Intra	SRGN	P10124	MBL2	Homo sapiens	P11226	ELISA	21268013
Intra	SRGN	P10124	PEX12	Homo sapiens	O00623	Y2H Prey Pooling	32296183
Intra	SRGN	P10124	PEX12	Homo sapiens	O00623	Y2H Array	32296183
Intra	SRGN	P10124	UBQLN1	Homo sapiens	Q9UMX0	Y2H Prey Pooling	32296183
Intra	SRGN	P10124	UBQLN1	Homo sapiens	Q9UMX0	Validated Y2H	25416956
Intra	SRGN	P10124	UBQLN1	Homo sapiens	Q9UMX0	Validated Y2H	32296183
Intra	SRGN	P10124	UBQLN1	Homo sapiens	Q9UMX0	Y2H Array	25416956
Intra	SRGN	P10124	UBQLN1	Homo sapiens	Q9UMX0	Y2H Array	32296183
Intra	SRGN	P10124	UBQLN1	Homo sapiens	Q9UMX0	Y2H Prey Pooling	25416956
Intra	SRGN	P10124	SGTB	Homo sapiens	Q96EQ0	Y2H Prey Pooling	32296183
Intra	SRGN	P10124	SGTB	Homo sapiens	Q96EQ0	Validated Y2H	32296183
Intra	SRGN	P10124	SGTB	Homo sapiens	Q96EQ0	Y2H Array	32296183
Intra	SRGN	P10124	NCALD	Homo sapiens	P61601	Y2H Prey Pooling	32296183
Intra	SRGN	P10124	NCALD	Homo sapiens	P61601	Validated Y2H	32296183
Intra	SRGN	P10124	NCALD	Homo sapiens	P61601	Y2H Array	32296183
Intra	SRGN	P10124	UBQLN2	Homo sapiens	Q9UHD9	Y2H Prey Pooling	32296183
Intra	SRGN	P10124	UBQLN2	Homo sapiens	Q9UHD9	Y2H Array	32296183
Intra	SRGN	P10124	UBQLN2	Homo sapiens	Q9UHD9	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant SRGN Proteins

Cat. No.	Product Name	Accession	Purity
HY-P76058	Serglycin/SRGN Protein, Human (HEK293, His-Myc)	AAA60179.1 (Y28-L158)	≥ 90%, as determined by reducing SDS-PAGE.
HY-P76059	Serglycin/SRGN Protein, Human (HEK293, His)	CAA34900.1/AAA60179.1 (Y28-L158)	≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Mucinoses
Central Corneal Ulcer

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13766	SRGN Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17592	Srgn Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24052	Srgn Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	SRGN	MGD	MGI:97756
Bos taurus	SRGN	VGNC	VGNC:35280
Canis familiaris	SRGN	VGNC	VGNC:46803
Macaca mulatta	SRGN	VGNC	VGNC:106106
Rattus norvegicus	SRGN	RGD	RGD:619969
Others	SRGN	NCBI