SLC30A10 - solute carrier family 30 member 10 Gene

Also Known as ZNT8; ZRC1; HMDPC; ZNT10; ZnT-10; HMNDYT1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 55532

About SLC30A10

Cytogenetic location: 1q41 Genomic coordinates (GRCh38): 1:219,910,445-219,959,098 (from NCBI)

This gene has 5 transcripts (splice variants), 171 orthologues, 8 paralogues and is associated with 2 phenotypes. Biased expression in duodenum (RPKM 12.8), liver (RPKM 7.9) and 4 other tissues.

Summary

This gene is highly expressed in the liver and is inducible by manganese. Its protein product appears to be critical in maintaining manganese levels, and has higher specificity for manganese than zinc. Loss of function mutations appear to result in a pleomorphic phenotype, including dystonia and adult-onset parkinsonism. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Mar 2012]

SLC30A10 Products (2)

mRNA Protein Name
NM_001376929.1 NP_001363858.1 zinc transporter 10 isoform 2
NM_018713.3 NP_061183.2 zinc transporter 10 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables calcium:manganese antiporter activity IDA
IDA: Inferred from direct assay
30755481 GOA
enables manganese ion transmembrane transporter activity IDA
IDA: Inferred from direct assay
25319704 GOA
enables manganese ion transmembrane transporter activity IMP
IMP: Inferred from mutant phenotype
27226609 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
26728129 GOA
NOT enables zinc ion transmembrane transporter activity IDA
IDA: Inferred from direct assay
30755481 GOA
enables zinc ion transmembrane transporter activity IDA
IDA: Inferred from direct assay
22427991 GOA
Biological Process GO Annotation Evidence References Source
involved in cellular response to angiotensin IDA
IDA: Inferred from direct assay
22427991 GOA
acts upstream of or within epidermal growth factor receptor signaling pathway IDA
IDA: Inferred from direct assay
26728129 GOA
NOT involved in intracellular copper ion homeostasis IDA
IDA: Inferred from direct assay
25319704 GOA
involved in intracellular manganese ion homeostasis IDA
IDA: Inferred from direct assay
25319704 GOA
involved in intracellular manganese ion homeostasis IMP
IMP: Inferred from mutant phenotype
22341972 GOA
NOT involved in intracellular zinc ion homeostasis IDA
IDA: Inferred from direct assay
25319704 GOA
involved in intracellular zinc ion homeostasis IDA
IDA: Inferred from direct assay
22427991 GOA
NOT involved in intracellular zinc ion homeostasis IMP
IMP: Inferred from mutant phenotype
27226609 GOA
involved in manganese ion export across plasma membrane IDA
IDA: Inferred from direct assay
25319704 GOA
involved in manganese ion export across plasma membrane IMP
IMP: Inferred from mutant phenotype
27307044 GOA
involved in manganese ion transport IMP
IMP: Inferred from mutant phenotype
22341972 GOA
acts upstream of positive regulation of ERK1 and ERK2 cascade IDA
IDA: Inferred from direct assay
26728129 GOA
involved in zinc ion import into organelle IDA
IDA: Inferred from direct assay
22427991 GOA
Cellular Component GO Annotation Evidence References Source
located in Golgi apparatus IDA
IDA: Inferred from direct assay
22706290 GOA
located in early endosome IDA
IDA: Inferred from direct assay
26728129 GOA
located in early endosome membrane IDA
IDA: Inferred from direct assay
22427991 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
25319704 GOA
located in recycling endosome IDA
IDA: Inferred from direct assay
26728129 GOA
located in recycling endosome membrane IDA
IDA: Inferred from direct assay
22427991 GOA
NOT located in synaptic vesicle IDA
IDA: Inferred from direct assay
26728129 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLC30A10 Protein Structure

Cation_efflux

Cation_efflux: Cation efflux family (11 - 385)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 485 a.a.
Protein Preferred Names Protein Names

zinc transporter 10

  • manganese transporter SLC30A10

SLC30A10 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
SLC30A10 Q6XR72 SLC30A3 Homo sapiens Q99726
Crosslink
26728129
Intra
SLC30A10 Q6XR72 SLC30A3 Homo sapiens Q99726
Anti Tag CoIP
26728129
Intra
SLC30A10 Q6XR72 SLC30A2 Homo sapiens Q9BRI3
Confocal
26728129
Intra
SLC30A10 Q6XR72 SLC30A2 Homo sapiens Q9BRI3
Crosslink
26728129
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Hypermanganesemia With Dystonia 1

  • Hypermanganesemia With Dystonia, Polycythemia, And Cirrhosis

  • HMNDYT1

  • Hmdpc

  • Hypermanganesemia With Dystonia Polycythemia And Cirrhosis

  • Dystonia/Parkinsonism, Hypermanganesemia, Polycythemia, Chronic Liver Disease

  • Cirrhosis-Dystonia-Polycythemia-Hypermanganesemia Syndrome
Hypermanganesemia With Dystonia

  • Familial Manganese-Induced Neurotoxicity

  • Hmndyt
Parkinsonism

  • Parkinsonism-Plus

  • Idiopathic Parkinsonism

  • Primary Parkinsonism

  • Paralysis Agitans Syndrome

  • Parkinsonian Syndrome

  • Trembling Paralysis

  • Paralysis Agitans

  • Shaking Palsy

  • Shaking Paralysis
Polycythemia

  • Erythrocythemia

  • Polycythemia Vera

  • Polycythaemia Due To High Altitude
Dystonia

  • Dystonic Disease

  • Dystonic Disorder

  • Dystonia Disorders

  • Neuroleptic Dyskinesia
Type 1 Diabetes Mellitus 5

  • Diabetes Mellitus, Insulin-Dependent, 5

  • Latent Autoimmune Diabetes In Adults

  • IDDM5

  • Insulin-Dependent Diabetes Mellitus 5

  • T1D5

  • Lada

  • Type 1.5 Diabetes

  • Diabetes Mellitus, Insulin-Dependent, Type 5
Pancreatic Cystadenoma

  • Cystadenoma Of Pancreas
Type 1 Diabetes Mellitus 3

  • Diabetes Mellitus, Insulin-Dependent, 3

  • Iddm3

  • Insulin-Dependent Diabetes Mellitus 3

  • T1D3
Type 1 Diabetes Mellitus 12

  • Diabetes Mellitus, Insulin-Dependent, 12

  • IDDM12

  • Insulin-Dependent Diabetes Mellitus 12

  • T1D12

  • Type 1 Diabetes Mellitus 12, Susceptibility To

  • Diabetes Mellitus, Insulin-Dependent, Type 12
Diabetes Mellitus, Ketosis-Prone

  • Diabetic Ketoacidosis

  • KPD

  • Diabetes Mellitus, Ketosis-Prone, Susceptibility To

  • Ketosis-Prone Diabetes Mellitus

  • Diabetes Mellitus, Insulin-Dependent

  • Diabetic Ketoacidosis Nos

  • Dka - [Diabetic Ketoacidosis] Nos

  • Dka - [Diabetic Ketoacidosis] Without Coma

  • Dka - [Diabetic Ketoacidosis] With Coma
Type 1 Diabetes Mellitus

  • Diabetes Mellitus, Insulin-Dependent

  • Diabetes Mellitus Type 1

  • IDDM

  • Type 1 Diabetes

  • Insulin-Dependent Diabetes Mellitus

  • T1D

  • Juvenile-Onset Diabetes

  • Jod

  • Diabetes Mellitus, Type 1

  • Diabetes Mellitus, Insulin-Dependent-1

  • Type I Diabetes Mellitus

  • Autoimmune Diabetes

  • Juvenile Diabetes

  • Juvenile-Onset Diabetes Mellitus

  • Diabetes, Insulin Dependent

  • Insulin-Dependent Diabetes Mellitus-1

  • Diabetes Mellitus Insulin-Dependent

  • Diabetes Autoimmune

  • Diabetes Mellitus, Insulin-Dependent, Susceptibility To

  • Diabetes Mellitus, Type 1, Susceptibility To

  • Diabetes Type 1

  • Type I Diabetes

  • Diabetes, Autoimmune

  • T1dm - [Type 1 Diabetes Mellitus]

  • Iddm - [Insulin Dependent Diabetes Mellitus]

  • Type 1 Iddm

  • Juvenile Diabetes Mellitus Without Compications

  • Idiopathic Insulin-Dependent Diabetes Mellitus Without Complications

  • Juvenile-Onset Diabetes Mellitus Without Compications

  • Ketosis-Prone Diabetes Mellitus Without Compications

  • Juvenile-Onset-Type Diabetes Mellitus Without Compications
Type 1 Diabetes Mellitus 15

  • Diabetes Mellitus, Insulin-Dependent, 15

  • Iddm15

  • Insulin-Dependent Diabetes Mellitus 15

  • T1D15

  • Insulin-Dependent Diabetes Mellitus-15
Hirata Disease

  • Insulin Autoimmune Syndrome

  • Insulin Autoimmune Hypoglycemia
Dystonia 12

  • DYT12

  • Rdp

  • Generalized Dystonia

  • Dystonia-12

  • Rapid-Onset Dystonia-Parkinsonism

  • Familial Dystonia

  • Dystonia Musculorum Deformans

  • Dystonic Disorders

  • Idiopathic Familial Dystonia

  • Dystonia-Parkinsonism, Rapid-Onset

  • Fragments Of Torsion Dystonia

  • Dyt-Atp1a3

  • Rapid-Onset Dystonia Parkinsonism

  • Rodp

  • Dystonia, Type 12

  • Dystonia 3, Torsion, X-Linked

  • Idiopathic Non-Familial Dystonia

  • Symptomatic Torsion Dystonia

  • Dystonia Disorders
Gastrointestinal System Benign Neoplasm
Autoimmune Disease Of Endocrine System
Maturity-Onset Diabetes Of The Young

  • MODY

  • Maturity Onset Diabetes Mellitus In Young

  • Mason-Type Diabetes

  • Mason Type Diabetes

  • Maturity Onset Diabetes Of The Young

  • Mody Syndrome

  • Diabetes Of The Young, Maturity-Onset
Celiac Disease 1

  • Celiac Disease

  • Coeliac Disease

  • Celiac Sprue

  • Celiac Disease, Susceptibility To

  • Gluten-Sensitive Enteropathy

  • Nontropical Sprue

  • Sprue

  • CELIAC1

  • Celiac Disease, Susceptibility To, 1

  • Celiac Sprue 1

  • Celiac Sprue, Susceptibility To, 1

  • Gluten-Sensitive Enteropathy 1

  • Gluten-Sensitive Enteropathy, Susceptibility To, 1

  • Idiopathic Steatorrhea

  • Cœliac Disease

  • Gluten Intolerance

  • Gluten-Induced Enteropathy

  • Gluten Enteropathy

  • Celiac Disease, Susceptibility To, Type 1

  • Childhood Celiac Disease

  • Coeliac Rickets

  • Gee Disease

  • Gee-Herter Disease

  • Heubner-Herter Disease

  • Idiopathic Steatorrhoea

  • Thaysen'S Disease

  • Herter Gee Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13179 SLC30A10 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus SLC30A10 MGD MGI:2685058
Rattus norvegicus SLC30A10 RGD RGD:1305098
Bos taurus SLC30A10 VGNC VGNC:34806
Felis catus SLC30A10 VGNC VGNC:65308
Macaca mulatta SLC30A10 VGNC VGNC:106496
Canis familiaris SLC30A10 VGNC VGNC:53131
Others SLC30A10 NCBI