PRR5 - proline rich 5 Gene

Also Known as PP610; PROTOR1; PROTOR-1; FLJ20185k

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 55615

About PRR5

Cytogenetic location: 22q13.31 Genomic coordinates (GRCh38): 22:44,668,751-44,737,681 (from NCBI)

This gene has 18 transcripts (splice variants), 255 orthologues and 1 paralogue. Broad expression in fat (RPKM 9.7), spleen (RPKM 8.6) and 23 other tissues.

Summary

This gene encodes a protein with a proline-rich domain. This gene is located in a region of chromosome 22 reported to contain a tumor suppressor gene that may be involved in breast and colorectal tumorigenesis. The protein is a component of the mammalian target of rapamycin complex 2 (mTORC2), and it regulates platelet-derived growth factor (PDGF) receptor beta expression and PDGF signaling to Akt and S6K1. Alternative splicing and the use of alternative promoters results in transcripts encoding different isoforms. Read-through transcripts from this gene into the downstream Rho GTPase activating protein 8 (ARHGAP8) gene also exist, which led to the original description of PRR5 and ARHGAP8 being a single gene. [provided by RefSeq, Nov 2010]

PRR5 Products (6)

mRNA Protein Name
NM_001017528.3 NP_001017528.1 proline-rich protein 5 isoform 2
NM_001017529.3 NP_001017529.1 proline-rich protein 5 isoform 3
NM_001017530.2 NP_001017530.1 proline-rich protein 5 isoform 3
NM_001198721.2 NP_001185650.1 proline-rich protein 5 isoform 4
NM_015366.4 NP_056181.2 proline-rich protein 5 isoform 2
NM_181333.4 NP_851850.1 proline-rich protein 5 isoform 1

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
24550280 GOA
Cellular Component GO Annotation Evidence References Source
part of TORC2 complex IDA
IDA: Inferred from direct assay
22609986 GOA
part of TORC2 complex IPI
IPI: Inferred from physical interaction
17461779 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PRR5 Protein Structure

HbrB

HbrB: HbrB-like (36 - 164)

  • 0
  • 100
  • 200
  • 300
  • 388 a.a.
Protein Preferred Names Protein Names

proline-rich protein 5

  • Rho GTPase activating protein 8

PRR5 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
PRR5 P85299 YWHAH Homo sapiens Q04917
Anti Tag CoIP
33961781
Intra
PRR5 P85299 DLG1 Homo sapiens Q12959
Phage Display
24550280
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Endocervicitis
Dravet Syndrome

  • Severe Myoclonic Epilepsy Of Infancy

  • Severe Myoclonic Epilepsy In Infancy

  • Smei

  • Epileptic Encephalopathy, Early Infantile, 6

  • DRVT

  • Developmental And Epileptic Encephalopathy 6a

  • Dee6a

  • Eiee6

  • Developmental And Epileptic Encephalopathy, 6

  • Dee6

  • Developmental And Epileptic Encephalopathy 6

  • Early Infantile Epileptic Encephalopathy 6

  • Myoclonic Epilepsy, Severe, Of Infancy

  • Sme

  • Severe Myoclonus Epilepsy Of Infancy

  • Borderline Smei

  • Smeb

  • Smeb-M

  • Smeb-O

  • Smeb-Sw

  • Smei-Borderland

  • Smei-Borderland More Than One Feature

  • Smei-Borderland-Myoclonic Seizures

  • Smei-Borderland-Spike Wave

  • Intractable Childhood Epilepsy With Generalized Tonic-Clonic Seizures

  • ICEGTC

  • Infantile Severe Myoclonic Epilepsy

  • Epilepsy, Intractable Childhood, With Generalized Tonic-Clonic Seizures
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11232 PRR5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta PRR5 VGNC VGNC:107920
Mus musculus PRR5 MGD MGI:1924714
Rattus norvegicus PRR5 RGD RGD:1307954
Felis catus PRR5 VGNC VGNC:64387
Bos taurus PRR5 VGNC VGNC:33400
Canis familiaris PRR5 VGNC VGNC:45047
Others PRR5 NCBI