Hgs - hepatocyte growth factor-regulated tyrosine kinase substrate Gene

Also Known as Hrs

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 56084

Summary

Predicted to enable several functions, including identical protein binding activity; ubiquitin-dependent protein binding activity; and ubiquitin-like protein Ligase binding activity. Involved in endosome to lysosome transport. Located in cytosol; membrane; and secretory granule. Orthologous to human HGS (hepatocyte growth factor-regulated tyrosine kinase substrate). [provided by Alliance of Genome Resources, Apr 2022]

Hgs Products (3)

mRNA Protein Name
NM_001399619.1 NP_001386548.1 hepatocyte growth factor-regulated tyrosine kinase substrate isoform 2
NM_001399620.1 NP_001386549.1 hepatocyte growth factor-regulated tyrosine kinase substrate isoform 3
NM_019387.3 NP_062260.2 hepatocyte growth factor-regulated tyrosine kinase substrate isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
10825299 RGD
Biological Process GO Annotation Evidence References Source
involved in endosome to lysosome transport IMP
IMP: Inferred from mutant phenotype
19808888 RGD
Cellular Component GO Annotation Evidence References Source
located in secretory granule IDA
IDA: Inferred from direct assay
10825299 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

hepatocyte growth factor-regulated tyrosine kinase substrate

  • HGF-regulated tyrosine kinase substrate

  • SNAP-25-interacting protein Hrs-2

Hgs Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Hgs Q9JJ50 Hap1 Rattus norvegicus P54256
Anti Bait CoIP
12021262
Intra
Hgs Q9JJ50 Hap1 Rattus norvegicus P54256
Pull Down
12021262
Intra
Hgs Q9JJ50 Hap1 Rattus norvegicus P54256
Y2H
12021262
Intra
Hgs Q9JJ50 Hap1 Rattus norvegicus P54256-2
Density Sedimentation
12021262
Intra
Hgs Q9JJ50 Hap1 Rattus norvegicus P54256-2
Confocal
12021262
Intra
Hgs Q9JJ50 Hap1 Rattus norvegicus P54256-2
Pull Down
12021262
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-120434 AEG40826 Inhibitor / Phase 1
Inhibitory Antibodies (2)
Cat. No. Product Name Effect
Purity Phase
HY-P99299 Lexatumumab Inducer 99.87% Phase 2
HY-P990592 GSK-3050002 97.30% Phase 1

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06155 HGS Human Pre-designed siRNA Set A Pre-designed Set / Unkown
Bioactive MoleculesInhibitory Antibodies (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P991541 HGS101 / Unkown
HY-P991653 HGS004 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Hgs NCBI NCBI:9146