ZC3HAV1 - zinc finger CCCH-type containing, antiviral 1 Gene

Also Known as ZAP; ZC3H2; ARTD13; PARP13; FLB6421; ZC3HDC2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 56829

About ZC3HAV1

Cytogenetic location: 7q34 Genomic coordinates (GRCh38): 7:139,043,515-139,109,720 (from NCBI)

This gene has 5 transcripts (splice variants), 124 orthologues and 8 paralogues. Ubiquitous expression in bone marrow (RPKM 17.0), lymph node (RPKM 9.0) and 24 other tissues.

Summary

This gene encodes a CCCH-type Zinc Finger Protein. This Antiviral protein inhibits viral replication by recruiting cellular RNA degradation machineries to degrade viral mRNAs. The encoded protein plays an important role in the innate immune response against multiple DNA and RNA viruses, including Ebola virus, HIV and SARS-CoV-2 (which causes COVID-19). [provided by RefSeq, Sep 2021]

ZC3HAV1 Products (3)

mRNA Protein Name
NM_001363491.2 NP_001350420.1 zinc finger CCCH-type antiviral protein 1 isoform 3
NM_020119.4 NP_064504.2 zinc finger CCCH-type antiviral protein 1 isoform 1
NM_024625.4 NP_078901.3 zinc finger CCCH-type antiviral protein 1 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Références Source
NOT enables NAD+ binding IMP
IMP: Inferred from mutant phenotype
25635049 GOA
NOT enables NAD+-protein ADP-ribosyltransferase activity IDA
IDA: Inferred from direct assay
25043379 GOA
NOT enables NAD+-protein poly-ADP-ribosyltransferase activity IMP
IMP: Inferred from mutant phenotype
25635049 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
21102435 GOA
Biological Process GO Annotation Evidence Références Source
involved in negative regulation of viral genome replication IDA
IDA: Inferred from direct assay
21102435 GOA
involved in positive regulation of RIG-I signaling pathway IMP
IMP: Inferred from mutant phenotype
21102435 GOA
involved in positive regulation of canonical NF-kappaB signal transduction IMP
IMP: Inferred from mutant phenotype
21102435 GOA
involved in positive regulation of interferon-alpha production IDA
IDA: Inferred from direct assay
21102435 GOA
involved in positive regulation of interferon-beta production IDA
IDA: Inferred from direct assay
21102435 GOA
involved in positive regulation of mRNA catabolic process IDA
IDA: Inferred from direct assay
21876179 GOA
NOT involved in protein poly-ADP-ribosylation IMP
IMP: Inferred from mutant phenotype
25635049 GOA
involved in response to virus IDA
IDA: Inferred from direct assay
21876179 GOA
Cellular Component GO Annotation Evidence Références Source
located in cytoplasm IDA
IDA: Inferred from direct assay
21102435 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ZC3HAV1 Protein Structure

PARP

PARP: Poly(ADP-ribose) polymerase catalytic domain (728 - 894)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 902 a.a.
Protein Preferred Names Protein Names

zinc finger CCCH-type antiviral protein 1

  • ADP-ribosyltransferase diphtheria toxin-like 13

ZC3HAV1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Références
Intra
ZC3HAV1 Q7Z2W4 KRTAP10-6 Homo sapiens P60371
Y2H Prey Pooling
32296183
Intra
ZC3HAV1 Q7Z2W4 KRTAP10-6 Homo sapiens P60371
Y2H Array
32296183
Intra
ZC3HAV1 Q7Z2W4 MDFI Homo sapiens Q99750
Validated Y2H
32296183
Intra
ZC3HAV1 Q7Z2W4 MDFI Homo sapiens Q99750
Y2H Array
32296183
Intra
ZC3HAV1 Q7Z2W4 MDFI Homo sapiens Q99750
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-RS15997 ZC3HAV1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22055 Zc3hav1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28573 Zc3hav1 Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris ZC3HAV1 VGNC VGNC:48563
Mus musculus ZC3HAV1 MGD MGI:1926031
Bos taurus ZC3HAV1 VGNC VGNC:37111
Macaca mulatta ZC3HAV1 VGNC VGNC:79408
Felis catus ZC3HAV1 VGNC VGNC:67191
Rattus norvegicus ZC3HAV1 RGD RGD:628694
Others ZC3HAV1 NCBI