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LXN - latexin Gene

Also Known as ECI; TCI

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 56925

About LXN

Cytogenetic location: 3q25.32 Genomic coordinates (GRCh38): 3:158,666,414-158,672,648 (from NCBI)

This gene has 2 transcripts (splice variants), 191 orthologues and 1 paralogue. Ubiquitous expression in ovary (RPKM 17.1), gall bladder (RPKM 15.4) and 24 other tissues.

Summary

This gene encodes the only known protein inhibitor of zinc-dependent metallocarboxypeptidases. The encoded protein, latexin, downregulates the population size of hematopoietic stem cells. This protein is found to be downregulated in Cancer cells because of promoter hypermethylation. [provided by RefSeq, Jul 2020]

LXN Products (1)

mRNA	Protein	Name
NM_020169.4	NP_064554.3	latexin

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LXN Protein Structure

Latexin

0
100
200
222 a.a.

Protein Preferred Names	Protein Names
latexin	MUM

LXN Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	LXN	Q9BS40	MAGEA8	Homo sapiens	P43361	Y2H Array	25416956
Intra	LXN	Q9BS40	MAGEA8	Homo sapiens	P43361	Y2H Prey Pooling	25416956
Intra	LXN	Q9BS40	DNAJC11	Homo sapiens	Q9NVH1	Y2H Array	32296183
Intra	LXN	Q9BS40	DNAJC11	Homo sapiens	Q9NVH1	Y2H Prey Pooling	32296183
Intra	LXN	Q9BS40	DNAJC11	Homo sapiens	Q9NVH1	Validated Y2H	32296183
Intra	LXN	Q9BS40	NSMF	Homo sapiens	Q6X4W1-2	Y2H Prey Pooling	32296183
Intra	LXN	Q9BS40	NSMF	Homo sapiens	Q6X4W1-2	Y2H Array	32296183
Intra	LXN	Q9BS40	YIF1B	Homo sapiens	Q5BJH7-5	Y2H Prey Pooling	32296183
Intra	LXN	Q9BS40	YIF1B	Homo sapiens	Q5BJH7-5	Y2H Array	32296183
Intra	LXN	Q9BS40	IGSF11	Homo sapiens	Q5DX21-2	Y2H Prey Pooling	32296183
Intra	LXN	Q9BS40	IGSF11	Homo sapiens	Q5DX21-2	Y2H Array	32296183
Intra	LXN	Q9BS40	BOC	Homo sapiens	Q96DN7	Y2H Prey Pooling	32296183
Intra	LXN	Q9BS40	BOC	Homo sapiens	Q96DN7	Y2H Array	32296183
Intra	LXN	Q9BS40	CA3	Homo sapiens	P07451	Y2H Prey Pooling	32296183
Intra	LXN	Q9BS40	CA3	Homo sapiens	P07451	Y2H Array	32296183
Intra	LXN	Q9BS40	ZNF430	Homo sapiens	Q2NKJ9	Y2H Prey Pooling	32296183
Intra	LXN	Q9BS40	ZNF430	Homo sapiens	Q2NKJ9	Y2H Array	32296183
Intra	LXN	Q9BS40	MCMDC2	Homo sapiens	Q4G0Z9	Y2H Prey Pooling	32296183
Intra	LXN	Q9BS40	MCMDC2	Homo sapiens	Q4G0Z9	Y2H Array	32296183
Intra	LXN	Q9BS40	TRAIP	Homo sapiens	Q9BWF2	Y2H Array	32296183
Intra	LXN	Q9BS40	TRAIP	Homo sapiens	Q9BWF2	Y2H Prey Pooling	32296183
Intra	LXN	Q9BS40	TRAIP	Homo sapiens	Q9BWF2	Validated Y2H	32296183
Intra	LXN	Q9BS40	FCGR3A	Homo sapiens	A0A1W2PQB1	Y2H Array	32296183
Intra	LXN	Q9BS40	FCGR3A	Homo sapiens	A0A1W2PQB1	Y2H Prey Pooling	32296183
Intra	LXN	Q9BS40	COX6A1	Homo sapiens	P12074	Y2H Prey Pooling	32296183
Intra	LXN	Q9BS40	COX6A1	Homo sapiens	P12074	Y2H Array	32296183
Intra	LXN	Q9BS40	RNF4	Homo sapiens	P78317	Y2H Array	32296183
Intra	LXN	Q9BS40	RNF4	Homo sapiens	P78317	Y2H Prey Pooling	32296183
Intra	LXN	Q9BS40	PPP1R3C	Homo sapiens	Q9UQK1	Y2H Prey Pooling	32296183
Intra	LXN	Q9BS40	PPP1R3C	Homo sapiens	Q9UQK1	Validated Y2H	32296183
Intra	LXN	Q9BS40	PPP1R3C	Homo sapiens	Q9UQK1	Y2H Array	32296183
Intra	LXN	Q9BS40	CYBC1	Homo sapiens	Q9BQA9	Y2H Array	32296183
Intra	LXN	Q9BS40	CYBC1	Homo sapiens	Q9BQA9	Y2H Prey Pooling	32296183
Intra	LXN	Q9BS40	TMEM14A	Homo sapiens	Q9Y6G1	Validated Y2H	25416956
Intra	LXN	Q9BS40	ZKSCAN4	Homo sapiens	Q969J2	Y2H Array	32296183
Intra	LXN	Q9BS40	ZKSCAN4	Homo sapiens	Q969J2	Y2H Prey Pooling	25416956
Intra	LXN	Q9BS40	ZKSCAN4	Homo sapiens	Q969J2	Y2H Prey Pooling	32296183
Intra	LXN	Q9BS40	ZKSCAN4	Homo sapiens	Q969J2	Y2H Array	25416956
Intra	LXN	Q9BS40	DPYD	Homo sapiens	Q12882	Validated Y2H	25416956
Intra	LXN	Q9BS40	SPAG7	Homo sapiens	O75391	Y2H Prey Pooling	32296183
Intra	LXN	Q9BS40	SPAG7	Homo sapiens	O75391	Y2H Array	32296183
Intra	LXN	Q9BS40	SHKBP1	Homo sapiens	Q8TBC3	Y2H Array	32296183
Intra	LXN	Q9BS40	SHKBP1	Homo sapiens	Q8TBC3	Y2H Prey Pooling	32296183
Intra	LXN	Q9BS40	TRIM39	Homo sapiens	Q9HCM9	Validated Y2H	25416956
Intra	LXN	Q9BS40	ZNF679	Homo sapiens	Q8IYX0	Y2H Array	32296183
Intra	LXN	Q9BS40	ZNF679	Homo sapiens	Q8IYX0	Y2H Prey Pooling	32296183
Intra	LXN	Q9BS40	ZCCHC17	Homo sapiens	Q9NP64	Y2H Prey Pooling	32296183
Intra	LXN	Q9BS40	ZCCHC17	Homo sapiens	Q9NP64	Validated Y2H	32296183
Intra	LXN	Q9BS40	ZCCHC17	Homo sapiens	Q9NP64	Y2H Array	32296183
Intra	LXN	Q9BS40	PAX6	Homo sapiens	P26367	Y2H Array	32296183
Intra	LXN	Q9BS40	PAX6	Homo sapiens	P26367	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant LXN Proteins

Cat. No.	Product Name	Accession	Purity
HY-P73841	Latexin Protein, Human (His)	Q9BS40/NP_064554.3 (E2-E222)	≥ 95%, as determined by Bis-Tris PAGE.
HY-P73842	Latexin Protein, Human (HEK293, Fc)	Q9BS40 (E2-E222)	≥ 90%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Lissencephaly 7 With Cerebellar Hypoplasia	LIS7 Lissencephaly 7, With Cerebellar Hypoplasia Lissencephaly, Type 7, With Cerebellar Hypoplasia
Lissencephaly 8	LIS8
Encephalitozoonosis	Infection By Encephalitozoon
Amyloidosis, Familial Visceral	Ostertag Type Amyloidosis German Type Amyloidosis Familial Renal Amyloidosis Amyloidosis Viii Amyloidosis, 3 Or More Types Familial Visceral Amyloidosis Familial Amyloid Nephropathy Hereditary Amyloid Nephropathy Amyloidosis, Familial Renal Amyloidosis, Systemic Nonneuropathic Amyloidosis Familial Visceral Amyloidosis 8 Amyloidosis, Ostertag Type Hereditary Amyloidosis With Primary Renal Involvement Hereditary Renal Amyloidosis Renal Amyloidosis Amyloidosis, Renal Systemic Nonneuropathic Amyloidosis Amyloidosis Familial Renal Amyloidosis Systemic Nonneuropathic Hereditary Amyloidosis With Primary Renal Involement AMYL8 Systemic Non-Neuropathic Amyloidosis Amyloid Nephropathy
Comedo Carcinoma	Comedocarcinoma High Grade Ductal Breast Carcinoma In Situ

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS25388	Lxn Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS07895	LXN Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18897	Lxn Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	LXN	VGNC	VGNC:63332
Rattus norvegicus	LXN	RGD	RGD:68361
Mus musculus	LXN	MGD	MGI:107633
Macaca mulatta	LXN	VGNC	VGNC:74279
Bos taurus	LXN	VGNC	VGNC:31087
Canis familiaris	LXN	VGNC	VGNC:42871
Others	LXN	NCBI