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PTPN9 - protein tyrosine phosphatase non-receptor type 9 Gene

Also Known as MEG2; PTPMEG2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 5780

About PTPN9

Cytogenetic location: 15q24.2 Genomic coordinates (GRCh38): 15:75,463,251-75,579,315 (from NCBI)

This gene has 5 transcripts (splice variants), 205 orthologues and 35 paralogues. Ubiquitous expression in thyroid (RPKM 22.0), small intestine (RPKM 10.6) and 25 other tissues.

Summary

The protein encoded by this gene is a member of the protein tyrosine Phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an N-terminal domain that shares a significant similarity with yeast SEC14, which is a protein that has phosphatidylinositol transfer activity and is required for protein secretion through the Golgi complex in yeast. This PTP was found to be activated by polyphosphoinositide, and is thought to be involved in signaling events regulating phagocytosis. [provided by RefSeq, Jul 2008]

PTPN9 Products (1)

mRNA	Protein	Name
NM_002833.4	NP_002824.1	tyrosine-protein phosphatase non-receptor type 9

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	12907755	GOA
enables protein tyrosine phosphatase activity	IDA IDA: Inferred from direct assay	19167335	GOA

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within negative regulation of neuron projection development	IDA IDA: Inferred from direct assay	27655914	GOA
acts upstream of or within peptidyl-tyrosine dephosphorylation	IDA IDA: Inferred from direct assay	27655914	GOA
acts upstream of or within positive regulation of protein localization to plasma membrane	IDA IDA: Inferred from direct assay	27655914	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	10940933	GOA
located in neuron projection terminus	IDA IDA: Inferred from direct assay	27655914	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PTPN9 Protein Structure

CRAL_TRIO_N

CRAL_TRIO

Y_phosphatase

0
100
200
300
400
500
593 a.a.

Protein Preferred Names	Protein Names
tyrosine-protein phosphatase non-receptor type 9	PTPase-MEG2

PTPN9 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	PTPN9	P43378	SLC30A8	Homo sapiens	Q8IWU4	Validated Y2H	32296183
Intra	PTPN9	P43378	SLC30A8	Homo sapiens	Q8IWU4	Y2H Prey Pooling	32296183
Intra	PTPN9	P43378	SLC30A8	Homo sapiens	Q8IWU4	Y2H Array	32296183
Intra	PTPN9	P43378	HSD17B11	Homo sapiens	Q8NBQ5	Y2H Array	32296183
Intra	PTPN9	P43378	HSD17B11	Homo sapiens	Q8NBQ5	Y2H Prey Pooling	32296183
Intra	PTPN9	P43378	HSD17B11	Homo sapiens	Q8NBQ5	Validated Y2H	32296183
Intra	PTPN9	P43378	SPAG4	Homo sapiens	Q9NPE6	Y2H Prey Pooling	32296183
Intra	PTPN9	P43378	SPAG4	Homo sapiens	Q9NPE6	Validated Y2H	32296183
Intra	PTPN9	P43378	SPAG4	Homo sapiens	Q9NPE6	Y2H Array	32296183
Intra	PTPN9	P43378	COQ3	Homo sapiens	Q9NZJ6	Validated Y2H	32296183
Intra	PTPN9	P43378	COQ3	Homo sapiens	Q9NZJ6	Y2H Prey Pooling	32296183
Intra	PTPN9	P43378	COQ3	Homo sapiens	Q9NZJ6	Y2H Array	32296183
Intra	PTPN9	P43378	FAM114A2	Homo sapiens	Q9NRY5	Validated Y2H	32296183
Intra	PTPN9	P43378	FAM114A2	Homo sapiens	Q9NRY5	Y2H Prey Pooling	32296183
Intra	PTPN9	P43378	FAM114A2	Homo sapiens	Q9NRY5	Y2H Array	32296183
Intra	PTPN9	P43378	ARL13B	Homo sapiens	Q3SXY8	Validated Y2H	32296183
Intra	PTPN9	P43378	ARL13B	Homo sapiens	Q3SXY8	Y2H Array	32296183
Intra	PTPN9	P43378	ARL13B	Homo sapiens	Q3SXY8	Y2H Prey Pooling	32296183
Intra	PTPN9	P43378	AGTRAP	Homo sapiens	Q6RW13-2	Validated Y2H	32296183
Intra	PTPN9	P43378	AGTRAP	Homo sapiens	Q6RW13-2	Y2H Array	32296183
Intra	PTPN9	P43378	AGTRAP	Homo sapiens	Q6RW13-2	Y2H Prey Pooling	32296183
Intra	PTPN9	P43378	CMTM5	Homo sapiens	Q96DZ9-2	Validated Y2H	32296183
Intra	PTPN9	P43378	CMTM5	Homo sapiens	Q96DZ9-2	Y2H Array	32296183
Intra	PTPN9	P43378	CMTM5	Homo sapiens	Q96DZ9-2	Y2H Prey Pooling	32296183
Intra	PTPN9	P43378	RTN3	Homo sapiens	O95197-3	Y2H Array	32296183
Intra	PTPN9	P43378	RTN3	Homo sapiens	O95197-3	Y2H Prey Pooling	32296183
Intra	PTPN9	P43378	TMEM80	Homo sapiens	Q96HE8	Y2H Prey Pooling	32296183
Intra	PTPN9	P43378	TMEM80	Homo sapiens	Q96HE8	Validated Y2H	32296183
Intra	PTPN9	P43378	TMEM80	Homo sapiens	Q96HE8	Y2H Array	32296183
Intra	PTPN9	P43378	SLC16A13	Homo sapiens	Q7RTY0	Y2H Prey Pooling	32296183
Intra	PTPN9	P43378	SLC16A13	Homo sapiens	Q7RTY0	Validated Y2H	32296183
Intra	PTPN9	P43378	SLC16A13	Homo sapiens	Q7RTY0	Y2H Array	32296183
Intra	PTPN9	P43378	TMCO2	Homo sapiens	Q7Z6W1	Y2H Array	32296183
Intra	PTPN9	P43378	TMCO2	Homo sapiens	Q7Z6W1	Y2H Prey Pooling	32296183
Intra	PTPN9	P43378	TMCO2	Homo sapiens	Q7Z6W1	Validated Y2H	32296183
Intra	PTPN9	P43378	AQP6	Homo sapiens	Q13520	Y2H Prey Pooling	32296183
Intra	PTPN9	P43378	AQP6	Homo sapiens	Q13520	Validated Y2H	32296183
Intra	PTPN9	P43378	AQP6	Homo sapiens	Q13520	Y2H Array	32296183
Intra	PTPN9	P43378	REEP6	Homo sapiens	Q96HR9-2	Validated Y2H	32296183
Intra	PTPN9	P43378	REEP6	Homo sapiens	Q96HR9-2	Y2H Array	32296183
Intra	PTPN9	P43378	REEP6	Homo sapiens	Q96HR9-2	Y2H Prey Pooling	32296183
Intra	PTPN9	P43378	CMTM4	Homo sapiens	Q8IZR5-2	Validated Y2H	32296183
Intra	PTPN9	P43378	CMTM4	Homo sapiens	Q8IZR5-2	Y2H Array	32296183
Intra	PTPN9	P43378	CMTM4	Homo sapiens	Q8IZR5-2	Y2H Prey Pooling	32296183
Intra	PTPN9	P43378	GJB1	Homo sapiens	P08034	Y2H Array	32296183
Intra	PTPN9	P43378	GJB1	Homo sapiens	P08034	Y2H Prey Pooling	32296183
Intra	PTPN9	P43378	CPLX4	Homo sapiens	Q7Z7G2	Y2H Array	32296183
Intra	PTPN9	P43378	CPLX4	Homo sapiens	Q7Z7G2	Y2H Prey Pooling	32296183
Intra	PTPN9	P43378	CPLX4	Homo sapiens	Q7Z7G2	Validated Y2H	32296183
Intra	PTPN9	P43378	HSD17B13	Homo sapiens	Q7Z5P4	Y2H Prey Pooling	32296183
Intra	PTPN9	P43378	HSD17B13	Homo sapiens	Q7Z5P4	Y2H Array	32296183
Intra	PTPN9	P43378	HSD17B13	Homo sapiens	Q7Z5P4	Validated Y2H	32296183
Intra	PTPN9	P43378	GET1	Homo sapiens	O00258	Y2H Prey Pooling	32296183
Intra	PTPN9	P43378	GET1	Homo sapiens	O00258	Y2H Array	32296183
Intra	PTPN9	P43378	TMEM86B	Homo sapiens	Q8N661	Validated Y2H	32296183
Intra	PTPN9	P43378	TMEM86B	Homo sapiens	Q8N661	Y2H Prey Pooling	32296183
Intra	PTPN9	P43378	TMEM86B	Homo sapiens	Q8N661	Y2H Array	32296183
Intra	PTPN9	P43378	ATP5PF	Homo sapiens	P18859	Y2H Prey Pooling	32296183
Intra	PTPN9	P43378	ATP5PF	Homo sapiens	P18859	Y2H Array	32296183
Intra	PTPN9	P43378	CERS4	Homo sapiens	Q9HA82	Validated Y2H	32296183
Intra	PTPN9	P43378	CERS4	Homo sapiens	Q9HA82	Y2H Array	32296183
Intra	PTPN9	P43378	CERS4	Homo sapiens	Q9HA82	Y2H Prey Pooling	32296183
Intra	PTPN9	P43378	YIF1A	Homo sapiens	O95070	Y2H Prey Pooling	32296183
Intra	PTPN9	P43378	YIF1A	Homo sapiens	O95070	Y2H Array	32296183
Intra	PTPN9	P43378	LIME1	Homo sapiens	Q9H400	Y2H Array	32296183
Intra	PTPN9	P43378	LIME1	Homo sapiens	Q9H400	Y2H Prey Pooling	32296183
Intra	PTPN9	P43378	LIME1	Homo sapiens	Q9H400	Validated Y2H	32296183
Intra	PTPN9	P43378	CDR1	Homo sapiens	P51861	Y2H Array	32296183
Intra	PTPN9	P43378	CDR1	Homo sapiens	P51861	Validated Y2H	32296183
Intra	PTPN9	P43378	CDR1	Homo sapiens	P51861	Y2H Prey Pooling	32296183
Intra	PTPN9	P43378	EBP	Homo sapiens	Q15125	Y2H Prey Pooling	32296183
Intra	PTPN9	P43378	EBP	Homo sapiens	Q15125	Validated Y2H	32296183
Intra	PTPN9	P43378	EBP	Homo sapiens	Q15125	Y2H Array	32296183
Intra	PTPN9	P43378	GORAB	Homo sapiens	Q5T7V8	Y2H Prey Pooling	32296183
Intra	PTPN9	P43378	GORAB	Homo sapiens	Q5T7V8	Validated Y2H	32296183
Intra	PTPN9	P43378	GORAB	Homo sapiens	Q5T7V8	Y2H Array	32296183
Intra	PTPN9	P43378	FKBP7	Homo sapiens	Q9Y680	Y2H Prey Pooling	32296183
Intra	PTPN9	P43378	FKBP7	Homo sapiens	Q9Y680	Validated Y2H	32296183
Intra	PTPN9	P43378	FKBP7	Homo sapiens	Q9Y680	Y2H Array	32296183
Intra	PTPN9	P43378	SLC7A1	Homo sapiens	P30825	Y2H Prey Pooling	32296183
Intra	PTPN9	P43378	PEX12	Homo sapiens	O00623	Y2H Prey Pooling	32296183
Intra	PTPN9	P43378	PEX12	Homo sapiens	O00623	Y2H Array	32296183
Intra	PTPN9	P43378	TMX2	Homo sapiens	Q9Y320	Y2H Prey Pooling	32296183
Intra	PTPN9	P43378	TMX2	Homo sapiens	Q9Y320	Validated Y2H	32296183
Intra	PTPN9	P43378	TMX2	Homo sapiens	Q9Y320	Y2H Array	32296183
Intra	PTPN9	P43378	CREB3L1	Homo sapiens	Q96BA8	Validated Y2H	32296183
Intra	PTPN9	P43378	CREB3L1	Homo sapiens	Q96BA8	Y2H Array	32296183
Intra	PTPN9	P43378	CREB3L1	Homo sapiens	Q96BA8	Y2H Prey Pooling	32296183
Intra	PTPN9	P43378	NSF	Homo sapiens	P46459	Pull Down	15322554
Intra	PTPN9	P43378	NSF	Homo sapiens	P46459	Phosphatase Assay	15322554
Intra	PTPN9	P43378	ARL6IP1	Homo sapiens	Q15041	Validated Y2H	32296183
Intra	PTPN9	P43378	ARL6IP1	Homo sapiens	Q15041	Y2H Array	32296183
Intra	PTPN9	P43378	ARL6IP1	Homo sapiens	Q15041	Y2H Prey Pooling	32296183
Intra	PTPN9	P43378	PLIN3	Homo sapiens	O60664	Y2H Array	32296183
Intra	PTPN9	P43378	PLIN3	Homo sapiens	O60664	Y2H Prey Pooling	32296183
Intra	PTPN9	P43378	RTN3	Homo sapiens	O95197	Validated Y2H	25416956
Intra	PTPN9	P43378	RTN3	Homo sapiens	O95197	Y2H Array	25416956
Intra	PTPN9	P43378	RTN3	Homo sapiens	O95197	Y2H Pooling	16189514
Intra	PTPN9	P43378	RTN3	Homo sapiens	O95197	Y2H Prey Pooling	25416956
Intra	PTPN9	P43378	PBX3	Homo sapiens	Q96AL5	Validated Y2H	32296183
Intra	PTPN9	P43378	PBX3	Homo sapiens	Q96AL5	Y2H Array	32296183
Intra	PTPN9	P43378	PBX3	Homo sapiens	Q96AL5	Y2H Prey Pooling	32296183
Intra	PTPN9	P43378	AGTRAP	Homo sapiens	Q6RW13	Validated Y2H	25416956
Intra	PTPN9	P43378	DERL2	Homo sapiens	Q9GZP9	Y2H Prey Pooling	32296183
Intra	PTPN9	P43378	DERL2	Homo sapiens	Q9GZP9	Validated Y2H	32296183
Intra	PTPN9	P43378	DERL2	Homo sapiens	Q9GZP9	Y2H Array	32296183
Intra	PTPN9	P43378	BSND	Homo sapiens	Q8WZ55	Validated Y2H	32296183
Intra	PTPN9	P43378	BSND	Homo sapiens	Q8WZ55	Y2H Array	32296183
Intra	PTPN9	P43378	BSND	Homo sapiens	Q8WZ55	Y2H Prey Pooling	32296183
Intra	PTPN9	P43378	SYP	Homo sapiens	P08247	Y2H Array	32296183
Intra	PTPN9	P43378	SYP	Homo sapiens	P08247	Y2H Prey Pooling	32296183
Intra	PTPN9	P43378	MAL2	Homo sapiens	Q969L2	Validated Y2H	25416956
Intra	PTPN9	P43378	MAL2	Homo sapiens	Q969L2	Y2H Array	25416956
Intra	PTPN9	P43378	MAL2	Homo sapiens	Q969L2	Y2H Prey Pooling	25416956
Intra	PTPN9	P43378	SCAMP1	Homo sapiens	O15126	Y2H Prey Pooling	32296183
Intra	PTPN9	P43378	SCAMP1	Homo sapiens	O15126	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant PTPN9 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P77170	PTP-MEG2/PTPN9 Protein, Human (sf9, His-GST)	P43378 (A285-Q593)	≥ 90%, as determined by reducing SDS-PAGE.

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-145923	Osunprotafib	Inhibitor	99.43%	Phase 1

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-N4150	Quercetagitrin	Inhibitor	98.33%	Unkown
HY-145923B	Osunprotafib hydrochloride	Inhibitor	/	Unkown
HY-RS11431	PTPN9 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20474	Ptpn9 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26982	Ptpn9 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	PTPN9	MGD	MGI:1928376
Macaca mulatta	PTPN9	VGNC	VGNC:76609
Rattus norvegicus	PTPN9	RGD	RGD:628726
Bos taurus	PTPN9	VGNC	VGNC:33543
Canis familiaris	PTPN9	VGNC	VGNC:45181
Felis catus	PTPN9	VGNC	VGNC:69167
Others	PTPN9	NCBI