RBM25 - RNA binding motif protein 25 Gene

Also Known as S164; NET52; RNPC7; Snu71; RED120; fSAP94

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 58517

About RBM25

Cytogenetic location: 14q24.2 Genomic coordinates (GRCh38): 14:73,058,534-73,123,899 (from NCBI)

This gene has 12 transcripts (splice variants) and 280 orthologues. Ubiquitous expression in bone marrow (RPKM 31.7), lymph node (RPKM 25.2) and 25 other tissues.

Summary

Enables mRNA binding activity. Involved in regulation of alternative mRNA splicing, via spliceosome and regulation of apoptotic process. Located in nuclear speck. [provided by Alliance of Genome Resources, Apr 2022]

RBM25 Products (1)

mRNA Protein Name
NM_021239.3 NP_067062.1 RNA-binding protein 25

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables mRNA binding IDA
IDA: Inferred from direct assay
18663000 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
18663000 GOA
Biological Process GO Annotation Evidence References Source
involved in regulation of alternative mRNA splicing, via spliceosome IDA
IDA: Inferred from direct assay
18663000 GOA
involved in regulation of apoptotic process IDA
IDA: Inferred from direct assay
18663000 GOA
Cellular Component GO Annotation Evidence References Source
located in nuclear speck IDA
IDA: Inferred from direct assay
18663000 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RBM25 Protein Structure

RRM_1

RRM_1: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (89 - 157)

PWI

PWI: PWI domain (770 - 838)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 843 a.a.
Protein Preferred Names Protein Names

RNA-binding protein 25

  • Arg/Glu/Asp-rich protein, 120 kDa

RBM25 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
RBM25 P49756 SRRM4 Homo sapiens A7MD48
Y2H Prey Pooling
32296183
Intra
RBM25 P49756 SRRM4 Homo sapiens A7MD48
Y2H Array
32296183
Intra
RBM25 P49756 PRPF40A Homo sapiens O75400
Anti Tag CoIP
33961781
Intra
RBM25 P49756 PRPF40A Homo sapiens O75400
Anti Tag CoIP
35271311
Intra
RBM25 P49756 GOLGA2 Homo sapiens Q08379
Y2H Prey Pooling
32296183
Intra
RBM25 P49756 GOLGA2 Homo sapiens Q08379
Validated Y2H
32296183
Intra
RBM25 P49756 GOLGA2 Homo sapiens Q08379
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

RBM25 Antibodies

Cat. No. Product Name Application Reactivity
HY-P811315 RBM25 Antibody WB, ICC/IF Human, Mouse

Related Diseases

Diseases Alias
Atrial Septal Defect 9

  • ASD9

  • Atrial Heart Septal Defect 9

  • Septal Defect, Atrial, Type 9
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11743 RBM25 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22769 Rbm25 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29283 Rbm25 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus RBM25 VGNC VGNC:80872
Macaca mulatta RBM25 VGNC VGNC:76521
Rattus norvegicus RBM25 RGD RGD:1308755
Bos taurus RBM25 VGNC VGNC:33794
Mus musculus RBM25 MGD MGI:1914289
Others RBM25 NCBI